Department of Chemistry

Gregory P. Tochtrop

Associate Professor of Chemistry

216.368.2351      gpt6@case.edu      Millis 410A

Tochtrop Research Group Site »

Interests: Biochemistry, Chemical Biology, Organic Chemistry, Bio-Organic Chemistry, Biophysical Chemistry, Medicinal Chemistry, Synthesis

B.S., University of Missouri, 1996
Ph.D., Washington University School of Medicine, 2002
NIH Postdoctoral Fellow, Harvard University, 2002-2006


Research in our lab centers on the chemistry and biology of lipids. Our central interests revolve around the identification of novel small molecules, and careful investigations into the chemistry and physiology of known molecules. From a training point of view, our work spans from pure synthetic organic chemistry to animal biology in disease models, and students in the laboratory have projects involving: target oriented synthesis, diversity oriented synthesis, protein biochemistry, metabolomics, and cell signaling. Our laboratory specializes in organic synthesis and protein biochemistry and we have developed strong collaborative relationships with other research groups at CWRU School of Medicine, and the Cleveland Clinic.

We are generally interested in two physiologic processes that are primarily driven by an exquisite network of small molecules.

The Linkage Between Oxidative Stress Pathways and Lipid Peroxidation

The Role of the Fatty Acid Binding Protein Family in Lipid Signaling

Selected Publications
  • Barker EC, Gatbonton-Schwager TN, Han Y, Clay, JE, Letterio JJ, Tochtrop GP*. Bryonolic Acid: A Large-Scale Isolation and Evaluation of Heme Oxygenase 1 Expression in Activated Macrophages. J. Nat. Prod. 2010, 73, 1064-1068.
  • Sadhukhan S, Han Y, Zhang G, Brunengraber H, Tochtrop GP*. Using Isotopic Tools to Dissect and Quantitate Parallel Metabolic Pathways. J. Am. Chem. Soc. 2010, 132, 6309-6311.
  • Zhang G, Kombu RS, Kasumov T, Han Y, Sadhukhan S, Zhang J, Sayre L, Ray D, Gibson KM, Anderson VA, Tochtrop GP, Brunengraber H. Catabolism of 4-Hydroxyacids and 4-Hydroxynonenal via 4-Hydroxy-4-phosphoacyl-CoAs. J. Biol. Chem. 2009; 284, 33521. Highlighted as paper of the week for Nov 27th 2009.