Visiting Professor, Center for Global Health and Diseases
PhD, 1992
University of Liverpool , UK . 
RESEARCH
My research focuses on the development and application of molecular diagnostic tools in field entomology. My particular interest is in studying the ecology and vectorial capacities of mosquito vectors of malaria and lymphatic filariasis. Malaria, caused by protozoan parasites, is the most important parasitic infection in people, accounting for more than 1 million deaths a year. Lymphatic filariasis caused by nematode parasites affects more than 128 million people in 80 countries. It is a major impediment to socioeconomic development in many developing countries because it causes permanent disability. Both diseases can be transmitted by several species of mosquitoes that differ in ecology and behavior. This contributes to the varying epidemiological patterns of the diseases seen worldwide. I am also involved in studies on the transmission of Japanese encephalitis in Papua New Guinea.
Setting up CDC light traps in PNG
I recently joined the faculty as a Visiting Professor from the Papua New Guinea Institute of Medical Research (PNGIMR) in Madang , Papua New Guinea . PNGIMR has had a long institutional relationship with Case Western Reserve University and I was the major foreign collaborator for many years. Collaborative studies on lymphatic filariasis in Papua New Guinea by myself and the Center Director, Dr, James Kazura, commenced in 1993. The early days of the affiliation focused on the epidemiology and control of bancroftian filariasis. The relationship became richer over the past 10 years when Dr. Chris King and Dr. Pete Zimmerman also started working with me on malaria in Papua New Guinea.
Dr Kazura and I recently received an ICIDR program award consisting of two interrelated projects. My own project in this program has the long term goal of determining the impact of combining mass drug administration with vector control on the transmission of bancroftian filariasis. Specific objectives include the determination of i) species composition, ecology and vectorial capacity of the filariasis vectors ii) the impact of mass treatment alone or in combination with vector control on transmission and iii) the role of Culex mosquitoes in the transmission of filariasis in Papua New Guinea. My other projects in Papua New Guinea include field entomological studies to determine malaria transmission rates in areas were Dr Zimmerman and Dr. King are conducting malaria studies. Dr Zimmerman and I are working also working on the development of a PCR-based genotyping assays to monitor permethrin resistance in mosquitoes.
CONTACT INFORMATION
Phone: (216) 368-6285
Fax: (216) 368-4825
Email: moses.bockarie@case.edu
PUBLICATIONS
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1. Bockarie MJ, Service MW, Barnish G, Toure YT , 1995. Vectorial capacity and entomological inoculation rates of Anopheles gambiae in a high rainfall forested area of southern Sierra Leone . Trop Med Parasitol 46: 164-71.
2. Bockarie M, Kazura J, Alexander N, Dagoro H, Bockarie F, Perry R, Alpers M, 1996. Transmission dynamics of Wuchereria bancrofti in East Sepik Province , Papua New Guinea . Am J Trop Med Hyg 54: 577-81.
3. Bockarie MJ, Alexander N, Bockarie F, Ibam E, Barnish G, Alpers M, 1996. The late biting habit of parous Anopheles mosquitoes and pre-bedtime exposure of humans to infective female mosquitoes. Trans R Soc Trop Med Hyg 90: 23-5.
4. Kazura JW, Bockarie M, Alexander N, Perry R, Bockarie F, Dagoro H, Dimber Z, Hyun P, Alpers MP, 1997. Transmission intensity and its relationship to infection and disease due to Wuchereria bancrofti in Papua New Guinea . J Infect Dis 176: 242-6.
5. Bockarie MJ, Alexander ND, Hyun P, Dimber Z, Bockarie F, Ibam E, Alpers MP, Kazura JW, 1998. Randomised community-based trial of annual single-dose diethylcarbamazine with or without ivermectin against Wuchereria bancrofti infection in human beings and mosquitoes. Lancet 351: 162-8.
6. Bockarie MJ, Hii JL, Alexander ND, Bockarie F, Dagoro H, Kazura JW, Alpers MP, 1999. Mass treatment with ivermectin for filariasis control in Papua New Guinea : impact on mosquito survival. Med Vet Entomol 13: 120-3.
7. Bockarie MJ, Gbakima AA, Barnish G, 1999. It all began with Ronald Ross: 100 years of malaria research and control in Sierra Leone (1899-1999). Ann Trop Med Parasitol 93: 213-24.
8. Bockarie MJ, Alexander ND, Kazura JW, Bockarie F, Griffin L, Alpers MP, 2000. Treatment with ivermectin reduces the high prevalence of scabies in a village in Papua New Guinea . Acta Trop 75: 127-30.
9. Bockarie MJ, Fischer P, Williams SA, Zimmerman PA, Griffin L, Alpers MP, Kazura JW, 2000. Application of a polymerase chain reaction-ELISA to detect Wuchereria bancrofti in pools of wild-caught Anopheles punctulatus in a filariasis control area in Papua New Guinea . Am J Trop Med Hyg 62: 363-7.
10. Bockarie MJ, Ibam E, Alexander ND, Hyun P, Dimber Z, Bockarie F, Alpers MP, Kazura JW, 2000. Towards eliminating lymphatic filariasis in Papua New Guinea : impact of annual single-dose mass treatment on transmission of Wuchereria bancrofti in East Sepik Province . P N G Med J 43: 172-82.
11. Bockarie MJ, Jenkins C, Blakie WM, Lagog M, Alpers MP, 2000. Control of lymphatic filariasis in a hunter-gatherer group in Madang Province . P N G Med J 43: 196-202.
12. King CL, Connelly M, Alpers MP, Bockarie M, Kazura JW, 2001. Transmission intensity determines lymphocyte responsiveness and cytokine bias in human lymphatic filariasis. J Immunol 166: 7427-36.
13. O'Donnell RA, de Koning-Ward TF, Burt RA, Bockarie M, Reeder JC, Cowman AF, Crabb BS, 2001. Antibodies against merozoite surface protein (MSP)-1(19) are a major component of the invasion-inhibitory response in individuals immune to malaria. J Exp Med 193: 1403-12.
14. Alexander ND, Bockarie MJ, Dimber ZB, Griffin L, Kazura JW, Alpers MP, 2001. Migration and dispersal of lymphatic filariasis in Papua New Guinea . Trans R Soc Trop Med Hyg 95: 277-9.
15. Tisch DJ, Hazlett FE, Kastens W, Alpers MP, Bockarie MJ, Kazura JW, 2001. Ecologic and biologic determinants of filarial antigenemia in bancroftian filariasis in Papua New Guinea . J Infect Dis 184: 898-904.
16. Bockarie MJ, Tavul L, Kastens W, Michael E, Kazura JW, 2002. Impact of untreated bednets on prevalence of Wuchereria bancrofti transmitted by Anopheles farauti in Papua New Guinea . Med Vet Entomol 16: 116-9.
17. Bockarie MJ, Tisch DJ, Kastens W, Alexander ND, Dimber Z, Bockarie F, Ibam E, Alpers MP, Kazura JW, 2002. Mass treatment to eliminate filariasis in Papua New Guinea . N Engl J Med 347: 1841-8.
18. Bockarie MJ, Kazura JW, 2003. Lymphatic filariasis in Papua New Guinea : prospects for elimination. Med Microbiol Immunol (Berl) 192: 9-14.
19. Zimmerman PA, Patel SS, Maier AG, Bockarie MJ, Kazura JW, 2003. Erythrocyte polymorphisms and malaria parasite invasion in Papua New Guinea . Trends Parasitol 19: 250-2.
20. Kazura JW, Bockarie MJ, 2003. Lymphatic filariasis in Papua New Guinea : interdisciplinary research on a national health problem. Trends Parasitol 19: 260-3.
21. Tobian AA, Tarongka N, Baisor M, Bockarie M, Kazura JW, King CL, 2003. Sensitivity and specificity of ultrasound detection and risk factors for filarial-associated hydroceles. Am J Trop Med Hyg 68: 638-42.
22. Alexander ND, Moyeed RA, Hyun PJ, Dimber ZB, Bockarie MJ, Stander J, Grenfell BT, Kazura JW, Alpers MP, 2003. Spatial variation of Anopheles-transmitted Wuchereria bancrofti and Plasmodium falciparum infection densities in Papua New Guinea . Filaria J 2: 14.
23. Cockburn IA, Mackinnon MJ, O'Donnell A, Allen SJ, Moulds JM, Baisor M, Bockarie M, Reeder JC, Rowe JA, 2004. A human complement receptor 1 polymorphism that reduces Plasmodium falciparum rosetting confers protection against severe malaria. Proc Natl Acad Sci U S A 101: 272-7.
24. VanBuskirk KM, Cole-Tobian JL, Baisor M, Sevova ES, Bockarie M, King CL, Adams JH, 2004. Antigenic drift in the ligand domain of Plasmodium vivax duffy binding protein confers resistance to inhibitory antibodies. J Infect Dis 190: 1556-62.
25. Trenholme KR, Boutlis CS, Kuns R, Lagog M, Bockarie MJ, Gatton ML, Kemp DJ, Good MF, Anstey NM, Gardiner DL, 2005. Antibody Reactivity To Linear Epitopes Of Plasmodium Falciparum Cytoadherence-Linked Asexual Gene 9 In Asymptomatic Children And Adults From Papua New G
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