Professor
Center for Global Health & Diseases and Department of Epidemiology and Biostatistics
M.D. 1978 State University of New York-Downstate Medical Center
M.S. University of Michigan School of Public Health, 2001
RESEARCH
Urinary schistosomiasis caused by Schistosoma haematobium remains a major health burden in areas of Africa and the Middle East, affecting more than 110 million people in rural, agricultural, and peri-urban areas. Individuals infected by S. haematobium frequently experience dysuria, pelvic pain, and hematuria, and are at risk of developing bladder cancer or renal failure later in life. In addition, schistosome infection is significantly associated with anemia, impaired growth, and impaired development and cognition. Consequently, schistosomiasis affects not only the health of individuals, but the economic strength of an affected area as well.
I am pursuing long-term collaborative research with Case colleagues and with the Ministry of Health (Kenya) on the epidemiology of schistosomiasis and other human parasite infections and the ecology of infectious disease transmission. Through recent collaborations with vector-borne disease specialists/ecologists at Emory University, and with public health specialists at University of Michigan, I am also pursuing the design of novel and optimal control strategies for disease due to schistosomiasis in Kenya and other endemic areas of the world.
These programs involve the implementation of new PCR and GIS database technologies for disease mapping and for modeling of spatially linked data, and new statistical approaches to study the influence of socio-economic and other household environmental factors in the transmission of chronic parasitic diseases. Formal clinical trials of the efficacy and effectiveness of different schistosomiasis control strategies are planned, including cost-benefit analysis from a societal perspective, to be performed in conjunction with Kenyan researchers and Health Economics colleagues.
Collateral studies have engaged us in the study of transmission of Rift Valley Fever during epidemic and inter-epidemic periods in Kenya, and in studies of the transmission of West Nile Virus in Cuyahoga County, in collaboration with the Cuyahoga County Board of Health.
 
Schistosoma haematobium egg and adult worm (Credits: CDC, WHO)
CONTACT INFORMATION
Phone: 216-368-3667
Fax: 216-368-4825
e-mail: chk@cwru.edu
RECENT PUBLICATIONS
Gurarie D, King CH. Heterogeneous model of schistosomiasis transmission and long-term control: the combined influence of spatial variation and age-dependent factors on optimal allocation of drug therapy. Parasitology. 2005 Jan;130(Pt 1):49-65.
Ouma JH, King CH, Muchiri EM, Mungai P, Koech DK, Ireri E, Magak P, Kadzo H. Late benefits 10-18 years after drug therapy for infection with Schistosoma haematobium in Kwale District, Coast Province, Kenya. Am J Trop Med Hyg. 2005 Aug;73(2):359-64.
Blossom DB, King CH, Armitage KB. Occult Plasmodium vivax infection diagnosed by a polymerase chain reaction-based detection system: a case report. Am J Trop Med Hyg. 2005 Jul;73(1):188-90.
King CH, Dickman K, Tisch DJ. Reassessment of the cost of chronic helmintic infection: a meta-analysis of disability-related outcomes in endemic schistosomiasis. Lancet. 2005 Apr 30-May 6;365(9470):1561-9.
Blanton RE, Salam EA, Ehsan A, King CH, Goddard KA. Schistosomal hepatic fibrosis and the interferon gamma receptor: a linkage analysis using single-nucleotide polymorphic markers. Eur J Hum Genet. 2005 May;13(5):660-8.
Kayanja HK, Debanne S, King CH, Whalen CC. Tuberculosis infection among health care workers in Kampala, Uganda. Int J Tuberc Lung Dis. 2005 Jun;9(6):686-8.
Gurarie D, Zimmerman PA, King CH. Dynamic regulation of single- and mixed-species malaria infection: insights to specific and non-specific mechanisms of control. J Theor Biol. 2006 May 21;240(2):185-99. Epub 2005 Nov 2.
Satayathum SA, Muchiri EM, Ouma JH, Whalen CC, King CH. Factors affecting infection or reinfection with Schistosoma haematobium in coastal Kenya: survival analysis during a nine-year, school-based treatment program. Am J Trop Med Hyg. 2006 Jul;75(1):83-92.
LaBeaud AD, Lisgaris MV, King CH, Mandalakas AM. Pediatric West Nile virus infection: neurologic disease presentations during the 2002 epidemic in Cuyahoga County, Ohio. Pediatr Infect Dis J. 2006 Aug;25(8):751-3.
Clennon JA, Mungai PL, Muchiri EM, King CH, Kitron U. Spatial and temporal variations in local transmission of Schistosoma haematobium in Msambweni, Kenya. Am J Trop Med Hyg. 2006 Dec;75(6):1034-41.
Clennon JA, King CH, Muchiri EM, Kitron U. Hydrological modelling of snail dispersal patterns in Msambweni, Kenya and potential resurgence of Schistosoma haematobium transmission. Parasitology. 2007 May;134(Pt 5):683-93. Epub 2006 Dec 11.
Kasehagen LJ, Mueller I, Kiniboro B, Bockarie MJ, Reeder JC, Kazura JW, Kastens W, McNamara DT, King CH, Whalen CC, Zimmerman PA. Reduced Plasmodium vivax erythrocyte infection in PNG Duffy-negative heterozygotes. PLoS ONE. 2007 Mar 28;2(3):e336.
Abbasi I, King CH, Sturrock RF, Kariuki C, Muchiri E, Hamburger J. Differentiation of Schistosoma haematobium from related schistosomes by PCR amplifying an inter-repeat sequence. Am J Trop Med Hyg. 2007 May;76(5):950-5.
LaBeaud AD, Kile JR, Kippes C, King CH, Mandalakas AM. Exposure to West Nile virus during the 2002 epidemic in Cuyahoga County, Ohio: a comparison of pediatric and adult behaviors. Public Health Rep. 2007 May-Jun;122(3):356-61
LaBeaud AD, Ochiai Y, Peters CJ, Muchiri EM, King CH. Spectrum of Rift Valley fever virus transmission in Kenya: insights from three distinct regions. Am J Trop Med Hyg. 2007 May;76(5):795-800.
LaBeaud AD, Gorman AM, Koonce J, Kippes C, McLeod J, Lynch J, Gallagher T, King CH, Mandalakas AM. Rapid GIS-based profiling of West Nile virus transmission: defining environmental factors associated with an urban-suburban outbreak in Northeast Ohio, USA. Geospat Health. 2008 May;2(2):215-25.
LaBeaud AD, Muchiri EM, Ndzovu M, Mwanje MT, Muiruri S, Peters CJ, King CH. Interepidemic Rift Valley fever virus seropositivity, northeastern Kenya. Emerg Infect Dis. 2008 Aug;14(8):1240-6.
Gurarie D, King CH. Age- and Risk-Targeted Control of Schistosomiasis—Associated Morbidity Among Children and Adult Age Groups. The Open Tropical Medicine Journal 2008, 1, 21-30. doi: 10.2174/1874315300801010021 http://www.bentham.org/open/totmj/openaccess2.htm
Bajunirwe F, Tisch DJ, King CH, Arts EJ, Debanne SM, Sethi AK. Quality of life and social support among patients receiving antiretroviral therapy in Western Uganda. AIDS Care. 2009 Mar;21(3):271-9.
Bajunirwe F, Arts EJ, Tisch DJ, King CH, Debanne SM, Sethi AK. Adherence and Treatment Response Among HIV-1-Infected Adults Receiving Antiretroviral Therapy in a Rural Government Hospital in Southwestern Uganda. J Int Assoc Physicians AIDS Care (Chic Ill). 2009 Mar 3. [Epub ahead of print]
Labeaud AD, Malhotra I, King MJ, King CL, King CH. Do antenatal parasite infections devalue childhood vaccination? PLoS Negl Trop Dis. 2009 May 26;3(5):e442.
Moormann AM, Odada Sumba P, Tisch DJ, Embury P, King CH, Kazura JW, John CC. Stability of Interferon gamma and interleukin-10 responses to Plasmodium falciparum Liver Stage Antigen-1 and Thrombospondin- Related Adhesive Protein in a highland population from western Kenya. Am J Trop Med Hyg. 2009 Sep;81(3):489-95.
La Beaud, AD, Glinka A, Kippes C, King CH, School-based health promotion for mosquito-borne disease prevention in children, Journal of Pediatrics, (in press).
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