Mark Chance, PhD

Director, Center for Proteomics and Bioinformatics Professor, Physiology and Biophysics

Mark Chance, PhD, is Professor of Physiology and Biophysics and Director of the Center for Proteomics and Bioinformatics the Case Western Reserve University School of Medicine. Dr. Chance received his PhD in Biophysics from the University of Pennsylvania in 1986. He spent a large portion of his career teaching at the Albert Einstein College of Medicine prior to joining the Case Western Reserve University School of Medicine and the Center for Proteomics and Bioinformatics in 2005.

The Chance lab uses quantitative mass spectrometry and 2-D gel techniques in order to identify biomarkers and regulatory pathways in complex diseases such as colon cancer, diabetes, radiation exposure, and HIV infection. A major emphasis is placed on applying state-of-the art proteomics and systems biology tools to investigate HIV pathogenesis in the context of drug abuse and provide significant biomarkers of HIV infection, co-infection with other viruses, and drug abuse. The use of high-resolution mass spectrometry instruments of the Center, coupled to the advanced bioinformatics and biostatistical pipelines for analysis, provide quantitative label free protein expression analysis using a "shotgun proteomics approach. Subsequent analysis using network and pathway tools provide novel insights into patho-physiological changes in this disease as well as the underlying immunobiology of progression.

Dr. Chance has received numerous awards including The Upjohn Company New Faculty Research Award and the Irma T. Hirschl Career Scientist Award. He has also published close to 200 manuscripts on his proteomics, mass spectrometry, 2D-gel, and bioinformatics research.