case western reserve university

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Preventing type 2 diabetes

Preventing type 2 diabetes

For people with type 2 diabetes, sitagliptin helps control blood sugar levels. New research from Case Western Reserve School of Medicine shows the same drug could also keep the disease from developing in those with pre-diabetes.

In biologic models, the drug performed two functions essential in controlling diabetes—increasing insulin production while also moderating the release of glucagon, a hormone that instructs the liver to flood the bloodstream with glucose, essentially working against insulin.

This dual effect could give the drug advantages over other diabetes medications by helping to shore up the function of the pancreas, which deteriorates during the onset of diabetes, according to study leader Paul Ernsberger, PhD, associate professor of nutrition.