Eric Pearlman, PhD
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Professor and Director of Research Department of Ophthalmology and Visual Sciences Case Western Reserve University 10900 Euclid Ave Cleveland, Ohio 44106 United States Phone: (216) 368-1856 Fax: (216) 368-3171 eric.pearlman@case.edu |
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Education/Training University of Glasgow, Scotland, B.S. 1978 Parasitology Hebrew University of Jerusalem, Israel, M.S. 1981 Microbiology University of Texas, San Antonio, TX, Ph.D. 1988 Microbiology Case Western Reserve University, Cleveland, OH, Post-doc 1988-1992 Immunology Positions and Employment 1992-1994 Instructor, Division of Geographic Medicine Case Western Reserve University, Cleveland, OH 1994-2000 Assistant Professor, Departments of Medicine and Ophthalmology, Case Western Reserve University, Cleveland, OH 2000-2002 Associate Professor, Departments of Medicine and Ophthalmology, Case Western Reserve University, Cleveland, OH 2002-2004 Associate Professor, Center for Global Health & Diseases and Department of Ophthalmology 2004-present Professor, Department of Ophthalmology, and the Center for Global Health and Diseases, Case Western Reserve University, Cleveland. 2004-present Director of Research, Department of Ophthalmology and Visual Sciences, CWRU Honors 1997 Burroughs Wellcome Foundation New Investigator Award. 2004 University of Western Australia Raine Foundation Visiting Professorship:. 2006 - Research to Prevent Blindness Foundation: Senior Investigator Award. 2008 – 2011 Permanent member, Anterior Eye Diseases study section, National Eye Institute Selected Peer-Reviewed Publications Pathogenesis of River blindness (EY10320) 1. Saint Andre, A.v., N.M. Blackwell, L.R. Hall, A. Hoerauf, N. W. Brattig, L. Volkmann, M. J. Taylor, L. Ford, A.G. Hise, J. H. Lass, E. Diaconu, and E. Pearlman, 2002. The role of endosymbiotic Wolbachia bacteria in the pathogenesis of River Blindness. Science 295:1892-1895. 2. Gillette-Ferguson, I., A.H. Hise, H. F. McGarry, J. Turner, A. Esposito, Y. Sun, E. Diaconu, M. Taylor and E. Pearlman. 2004. Wolbachia – induced neutrophil activation in ocular onchocerciasis (river blindness). Infect Immun. 72: 5687-5692. 3. Gillette-Ferguson, I., A. G. Hise, Y. Sun, E. Diaconu, H. F. McGarry, M. J. Taylor and E. Pearlman. 2006. Wolbachia and Onchocerca volvulus – induced keratitis (river blindness) is dependent on Myeloid Differentiation Factor 88. Infect Immun. 74:2442-2445. 4. Hise, A.G., K.Daehnel, I. Gillette-Ferguson, E. Cho, H. F. McGarry, M. J. Taylor, D. T. Golenbock, K. A. Fitzgerald, J. W. Kazura and E. Pearlman. 2007. Innate immune responses to endosymbiotic Wolbachia bacteria in Brugia malayi and Onchocerca volvulus are dependent on TLR2, TLR6, MyD88 and Mal, but not TLR4, TRIF or TRAM. J. Immunol. 178: 1068-1076. 5. Daehnel, K., I. Gillette-Ferguson, A.G. Hise, E. Diaconu, M. J. Harling, F. Heinzel, and E. Pearlman. 2007. Th1-, but not Th2-associated responses are dependent on Toll Like Receptor 2 in a mouse model of Ocular Onchocerciasis (river blindness). Parasite Immunol. 29. 463 - 473. 6. Gillette-Ferguson, I, K Daehnel, A. G. Hise, Y. Sun, E. Carlson, E. Diaconu, H. F. McGarry, M. J. Taylor and E. Pearlman. 2007. TLR2 regulates CXC chemokine production and neutrophil recruitment to the cornea in Onchocerca volvulus / Wolbachia keratitis (river blindness). Infect Immun. 75. 5908-5915. 7. Gentil, K. and E. Pearlman. 2009. IFN- regulation of CXC chemokine production and neutrophil recruitment to the corneal stroma is mediated by IL-1R1 in a murine model of O.volvulus/Wolbachia keratitis (river blindness). Infect Immun. 77:1606-1609. 8. J. D. Turner, R. S. Langley, K. Johnston, K. Daehnel, L. Ford, B. Wu, M. Graham, F. Sharpley, B. Slatko, E. Pearlman and M. J. Taylor. 2009. Filarial Wolbachia lipoprotein stimulates innate and adaptive inflammatory responses through TLR2 and TLR6 and induces disease manifestations of lymphatic filariasis and river blindness. J. Biol. Chem. May 19 pre-publication. Role of Extracellular Matrix in corneal inflammation (EY10320) 1. Lin, M., E. Carlson, E. Diaconu, and E. Pearlman. 2007. CXCL1/KC and CXCL5/ LIX are selectively produced by corneal fibroblasts and mediate neutrophil infiltration to the corneal stroma in LPS keratitis. J. Leuk. Biol. 81:786-792. 2. Carlson, E.C., M. Lin, C-Y. Liu, W-Y. Kao, V. L. Perez and E. Pearlman. 2007. Keratocan And Lumican Regulate Neutrophil Infiltration And Corneal Clarity In LPS-Induced Keratitis By Direct Interaction With KC/CXCL1. J. Biol. Chem. 282:35502-9. 3. Lin, M., P. Jackson, A. M. Tester, E. Diaconu, C. M. Overall, J. E. Blalock, and E. Pearlman. 2008. MMP-8 facilitates neutrophil migration through the corneal stromal matrix by collagen degradation and production of the chemotactic peptide Pro-Gly-Pro. Am. J. Path. 173:144-153. 4. Du Y, Carlson EC, Funderburgh ML, Birk DE, Pearlman E, Guo N, Kao WW, Funderburgh JL. Stem Cell Therapy Restores Transparency to Defective Murine Corneas. Stem Cells. 2009 Apr 9;27(7):1635-1642. [Epub ahead of print] 5. Carlson, Eric C1, Kao, Winston W-Y, Liu, Chia-Yang, Perez, Victor L., and Eric Pearlman. 2009. Regulation of inflammation by neutrophil dependent cleavage of keratan sulfate proteoglycans – A model for breakdown of the chemokine gradient. Under review, J. Biol Chem Toll Like Receptors in corneal inflammation (EY14362) 1. Khatri, S., J.H. Lass, F.P. Heinzel, W. M. Petroll, J. Gomez, E. Diaconu, C.M. Kalsow, and E. Pearlman. Regulation of Endotoxin-Induced Keratitis by PECAM-1, MIP-2, and Toll-like Receptor 4. Investigative Ophthalmology & Visual Science (IOVS) 43(7): 2278-2284, 2002. 2. Johnson, A.C., F. P. Heinzel, E. Diaconu, Y. Sun, A. G. Hise, D. Golenbock J. H. Lass and E. Pearlman. 2005. Activation of Toll-Like Receptor (TLR)2, TLR4, and TLR9 in the Mammalian Cornea Induces MyD88-Dependent Corneal Inflammation. IOVS. 46:589-595. 3. Sun, Y, C. M. Kalsow, A.G. Hise and E. Pearlman. 2006. Staphylococcus aureus – induced corneal inflammation is dependent on Toll-Like Receptor (TLR)2 and Myeloid Differentiation Factor-88 (MyD88). Infect Immun. 74: 5325 - 5332. 4. Chinnery, H., Ruitenberg, M., Plant, G., Pearlman, E., Jung, S. and McMenamin, PG. 2007. CX3CR1 expression in resident mouse corneal macrophages and Langerhans dendritic cells plays a role in their ability to populate the epithelium but not the stroma. Invest. Ophth. Vis. Sci. 48.1568 – 1574. 5. Johnson, AC., X. Li and E. Pearlman. 2008. MyD88 is a negative regulator of TLR3/TRIF -induced corneal inflammation via c-Jun N-terminal kinase (JNK). J. Biol. Chem. 283:3988-96. 6. Adhikary, G., Y. Sun, and E. Pearlman. 2008. C-Jun NH2 Terminal kinase (JNK) plays a major role in Staphylococcus aureus – induced, TLR2 - mediated keratitis. J. Leuk Biol. 83: 991-997. 7. Sun, Y., T. Fox, G. Adhikary, M. Kester and E. Pearlman 2008. Inhibition of corneal inflammation by liposomal delivery of short-chain, C-6 ceramide. J. Leuk Biol. 83:1512-1521. 8. Chinnery, H.R., Pearlman, E., and McMenamin, P.G. 2008. Membrane nanotubes in vivo: A novel feature of MHC class II+cells in the mouse cornea. J. Immunol. Cutting Edge. 180:5779-5783. 9. Chinnery HR, Humphries T, Clare A, Dixon AE, Howes K, Moran CB, Scott D, Zakrzewski M, Pearlman E, McMenamin PG. Turnover of bone marrow-derived cells in the irradiated mouse cornea. Immunology. 2008. Immunology, 125, 541–548. 10. Chinnery, H.R., E. C. Carlson, Y. Sun, M. Lin, S. H. Burnett, V. L. Perez, P. G. McMenamin and E. Pearlman. 2009. Bone marrow chimeras and c-fms conditional ablation (Mafia) mice reveal an essential role for resident myeloid cells in LPS/TLR4 -induced corneal inflammation. J. Immunol. 182;2738-2744. 11. Sun, Y and E. Pearlman. 2009. Inhibition of Corneal Inflammation by the TLR4 antagonist Eritoran tetrasodium (E5564). Invest. Ophth. Vis. Sci. 50:1247–1254. 12. Szczotka-Flynn L. B., Y. Imamura, J. Chandra, Y. Changping, P. K. Mukherjee, E. Pearlman, and M. A. Ghannoum. 2009. Increased resistance of contact lens related bacterial biofilms to antimicrobial activity of soft contact lens care solutions. Cornea. In Press. 13. Utz, V., Y Sun, R. Ramadan, E. Pearlman. 2009. Staphylococcus aureus keratitis is mediated by IL-1R1 and MyD88, but not TLR2 or MAL. Submitted to IOVS. Pathogenesis of Fungal keratitis (EY18612) 1. Imamura, Y., J. Chandra, P. K. Mukherjee, A.A. Lattif, L. B. Szczotka-Flynn, E. Pearlman, J. H. Lass and M. A. Ghannoum 2008. Development of an in vitro model of soft contact lens-associated Fusarium and Candida biofilms: Utility in testing ability of fungi to form biofilm on contact lenses and anti-biofilm activities of lens cleaning solutions. Antimicrobial Agents and Chemotherapy. 52:171-82. 2. Tarabishy, A. B., B. Aldabagh, Y. Sun, Y. Imamura, P. K. Mukherjee, J. H. Lass, M. A. Ghannoum, and E. Pearlman. 2008. MyD88 regulation of Fusarium solani keratitis is dependent on TLR4 and IL-1R1, not TLR2. J. Immunol. 181:593-600. 3. Sun, Y., Y. Imamura, P. Mukherjee, J. Chandra, L. Szczotka-Flynn, M. A. Ghannoum, and E. Pearlman. 2009. Regulation of keratitis caused by corneal surface exposure to Fusarium oxysporum biofilm on silicone hydrogel contact lenses. IOVS, In Press. 4. Leal Jr., S. M., S. Hastings, Y-C Hsia, M.A. Ghannoum, M. Momany, and E. Pearlman. 2009 Distinct Roles for Dectin-1 and TLR4 in the pathogenesis of Aspergillus fumigatus keratitis. Submitted to PLoS Pathogens. Invited reviews (selected from 19 reviews and book chapters). 1. Pearlman, E. and Gillette-Ferguson, I. 2007. Onchocerca volvulus, Wolbachia and River Blindness Disorders of the ocular surface: Immune Response and the Eye, 2nd Edition (J. Niederkorn, Ed). 92:254-65. 2. Pearlman, E., K. Daehnel, 2007. Wolbachia and Toll Like Receptors. In: Wolbachia: A bug's life in another bug. Edited by Heinz Zeichhardt, Berlin, and Brian Mahy, Atlanta. Karger. 3. Pearlman E. A.C Johnson, G. Adhikary, Y Sun, H. R. Chinnery, T. Fox, M. Kester, and P. G. McMenamin. 2008. Toll Like Receptors at the Ocular Surface. The Ocular Surface. 6: 108-116. 4. Pearlman, E. and K. Gentil. 2009. Immunopathogenesis of Onchocerciasis (River Blindness). In: Encyclopedia of the Eye (J. Niederkorn, Ed). In Press. 5. Pearlman, E., S.M. Leal, Jr., M. Momany and M.A. Ghannoum 2009. Pathogenesis of Fungal keratitis. In: Encyclopedia of the Eye (J. Niederkorn, Ed). In Press. Research Support Active Funding RO1EY018612 3/1/2008 – 2/28/2013 Title: Pathogenesis of Fungal Keratitis Role: Primary Investigator Agency: National Eye Institute Description: This project examines the role of c-type lectins in the pathogenesis of Fusarium keratitis Annual Direct costs: $290,000 5RO1 EY014362 9/1/2009 – 8/31/2013 Title: Toll Like Receptors in Bacterial Keratitis Role: Primary Investigator Agency: National Eye Institute Description: This project examines the role of toll like receptors in the innate immune response in bacterial keratitis and in response to bacterial products in the cornea Annual Direct costs: $250,000 P-30 EY11373 4/1/1998 – 3/30/2012 Title: Visual Sciences Core grant Role: Primary Investigator Agency: National Eye Institute Description: Support for five core modules – Histology and Imaging, Tissue culture and Hybridoma, Molecular Biology, Proteomics, Specialized Animal Resource Annual Direct costs: $500,000 Completed Projects 5R01 EY010320-1 12/1/1993 - 11/30/2008 Title: Pathogenesis of Ocular Onchocerciasis (River Blindness) Role: Primary Investigator Agency: National Eye Institute Description: This project studies the role of the innate and adaptive immunity and the role of endosymbiotic Wolbachia bacteria in the pathogenesis of ocular onchocerciasis (river blindness). Annual Direct costs: $225,000 Patents Co-inventor (with Mark Kester, Penn State): International Patent Application no. PCT/US2007/072905. Ceramide composition and method of use. Inventor 61/061291: Toll Like Receptors as targets for therapeutic and prophylactic invention in contact lens associated keratitis and sterile corneal infiltrates (filed 6/13/08). |
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