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Assistant Professor, Center for RNA Molecular Biology (Faculty since 2004) |
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Education: Ph.D.: Columbia University, 2003 M.D.: Iran University of Medical Sciences, 1996 |
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Secondary Appointment in: Department of Biochemistry |
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Email: sxv46 Office Location: Wood Blgd. RT 100-8 Office Phone: 216-368-1068 Office FAX: 216-368-2010 Laboratory Location: W11X and RT100 Laboratory Phone: 216-368-0371 |
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The main focus of research in my lab is elucidating the structure and function of the catalytic core of the spliceosome by taking advantage of a novel, minimal spliceosome we have recently developed. This minimal system, which consists of only two spliceosomal snRNAs, catalyzes a reaction identical to the splicing reaction. In addition to providing direct evidence for RNA catalysis in the spliceosome, and thus, settling the longstanding and central question of the identity of the catalytic domain, the minimal system provides a novel and powerful tool for studying the structure and function of the spliceosome. |
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Pubmed Link to Publications
Select Publications |
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