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   Specific research

Why have a focus on RNA research? RNA impacts nearly every aspect of gene expression and it is now clear that the majority of human genetic diseases are caused by mistakes in RNA metabolism. Furthermore, RNA processing accounts for nearly all of the proteomic diversity in human cells; we have only ~30,000 genes yet produce many times that number of proteins. Moreover, it is clear that in addition to its fundamental roles in information transfer from DNA to protein, RNA molecules play crucial roles in gene regulation; approximately 10% of all of our genes are regulatory RNAs.

Current research in the Center focuses on several of these problems ranging from extremely basic questions such as the mechanism of RNA catalysis and how proteins interact with RNA to the roles of RNA processing in disease. Specific research interests include splicing and its regulation, RNA editing, tRNA maturation, mechanisms of translation regulation, and RNA trafficking. As the Center continues to expand, we hope to recruit in new areas such as RNA interference and regulation of gene expression by microRNAs.


 

Pre-mRNA splicing and its regulation

Timothy Nilsen

Donny Licatalosi

RNA editing

Jonatha Gott

Translational regulation

Jeff Coller

Timothy Nilsen

Eckhard Jankowsky

Transcriptional regulation

Pieter deHaseth

Jeff Coller

JoAnn Wise

mRNA decay

Kristian Baker

Jeff Coller

RNA protein interactions

Eckhard Jankowsky

Donny Licatalosi

Non-Coding RNAs

Jeff Coller

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