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case western reserve university

REPRODUCTIVE BIOLOGY


MacDonald Women's Hospital  
University Hospitals  
Case Medical Center
  

 

Neal S. Rote, Ph.D.
William H. Weir, M.D. Professor of Reproductive Biology
Vice Chair for Academic Affairs
Director, Division of Research

 

E-mail:
neal.rote@case.edu
Office Location:
MacDonald 8018
Office Phone:
(216) 844-8131
Lab Location:
MacDonald 8119
Lab Phone:
(216) 844-8177

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Research Interests:
  The effects of antiphospholipid antibodies on pregnancy
Villous cytotrophoblast differentiation
Expression of placental endogenous retroviruses
Diagnosis and treatment of recurrent miscarriage
   
  Training:
 
B.A. (cum laude)
1969
Temple University, Philadelphia, PA, Biology
Ph.D.
1974
Temple University School of Medicine, Philadelphia, PA, Medical Microbiology and Immunology
Post-Doctoral Fellowships
1974-1976
Institute for Hygiene and Medical Microbiology, Heidelberg University School of Medicine, Heidelberg, Germany
1976-1978
Department of Surgery, Division of Oncology, UCLA School of Medicine, Los Angeles, CA, tumor immunology
   
  Academic and Administrative Appointments:
 
1978-1987
Associate Professor and Director, Research Laboratories
Departments of Obstetrics and Gynecology and Pathology, University of Utah School of Medicine, Salt Lake City, UT
1987-1990
Professor (Tenure) and Chair
Department of Applied Medical Sciences, University of Southern Maine, Portland, ME; and Director of Reproductive Immunology, Foundation for Blood Research, Scarborough, ME
1990-2001
Professor (Tenure) and Chair
Department of Microbiology and Immunology; Professor of Obstetrics and Gynecology and Biological Sciences; and Associate Dean for Graduate Programs (2000-2001), School of Medicine and College of Science and Mathematics, Wright State University, Dayton, OH
2001-present
Professor (Tenure)
Departments of Reproductive Biology and Pathology, Case School of Medicine, Case Western Reserve University, Cleveland, OH
2001-present
Director, Division of Research Department of Obstetrics and Gynecology, MetroHealth Medical Center (2001-2004) and Department of Obstetrics and Gynecology, MacDonald Women's Hospital, University Hospitals (2004-present)
2004-present Vice Chair for Academic Affairs Department of Obstetrics and Gynecology, MacDonald Women's Hospital, University Hospitals
   
  Recent Publications:
 

Rote NS, Stetzer B. Autoimmune disease as a cause of reproductive failure. In Prenatal Testing, ed J. Canick, Clinics in Laboratory Medicine, 23:265-293, 2003. (PubMed)

Das M, Xu B, Lin L, Chakrabarti S, Shivaswamy V, Rote NS. Phosphatidylserine efflux and intercellular fusion in a BeWo model of human villous cytotrophoblast. Placenta, 25:396-407, 2004. (PubMed)

Rote NS, Chakrabarti S, Stetzer B. The role of endogenous retroviruses in human placental development. Placenta, 25:673-683, 2004. (PubMed)

González F, Minium J, Rote NS, Kirwan JP. Hyperglycemia alters tumor necrosis factor-a release from mononuclear cells in women with polycystic ovary syndrome. Journal of Clinical Endocrinology and Metabolism, 90:5336-5342, 2005. (PubMed)

González F, Minium J, Rote NS, Kirwan JP. Altered tumor necrosis factor-a release from mononuclear cells of obese reproductive age women during hyperglycemia. Metabolism 55:271-277, 2006. (PubMed)

González F, Rote NS, Minium J, Kirwan JP. Reactive oxygen species-induced oxidative stress in the development of insulin resistance and hyperandrogenism in polycystic ovary syndrome. Journal of Clinical Endocrinology and Metabolism, 91:336-340, 2006. (PubMed)

González F, Rote NS, Minium J, Kirwan JP. In vitro evidence that hyperglycemia stimulates tumor necrosis factor-a release in obese women with polycystic ovary syndrome. Journal of Endocrinology, 188:521-529, 2006. (PubMed)

González F, Rote NS, Minium J, Kirwan JP. Increased activation of nuclear factor ?B triggers inflammation and insulin resistance in polycystic ovary syndrome. Journal of Clinical Endocrinology and Metabolism, 91:1508-1512, 2006. (PubMed)

Alpin JD, Straszewski-Chavez SL, Kalionis B, Dunk C, Morrish D, Forbes K, Baczyk D, Rote N, Malassine A, Knofler M. Trophoblast differentiation: progenitor cells, fusion, and migration: A workshop report. In Trophoblast Research Placenta: From Molecule to Morphology to Mother. (eds F Lyall, G Desoye, K Shiverick), Elsevier Ltd., Amsterdam, Placenta (Suppl 1):141-143, 2006. (PubMed)

   
  Recent Extramural Funding:
 

Antiphospholipid Antibody Heterogeneity, July 1, 2003 April 30, 2008, NIH, RO1 HD043566, PI: Neal S. Rote

Antibody-directed Targeting of Ovarian Cancer Blood Vessels, March 15, 2006 March 14, 2008, OROC (Out Run Ovarian Cancer) Advocacy and Research Group PI: Neal S. Rote, Co-Investigators: Vivian von Gruenigen, M.D., Steven Waggoner, M.D.

Placental Endogenous Retrovirus Expression, February 1, 2003 January 31, 2006, RO3 HD043546, PI: Neal S. Rote

Antiphospholipid Antibodies and Pregnancy Loss, August 1, 1988 - March 31, 2003, RO1 HD23697, PI: Neal S. Rote