The effects of antiphospholipid antibodies on pregnancy
Villous cytotrophoblast differentiation
Expression of placental endogenous retroviruses
Diagnosis and treatment of recurrent miscarriage
Training:
B.A. (cum laude)
1969
Temple University, Philadelphia, PA, Biology
Ph.D.
1974
Temple University School of Medicine, Philadelphia, PA, Medical Microbiology and Immunology
Post-Doctoral Fellowships
1974-1976
Institute for Hygiene and Medical Microbiology, Heidelberg University School of Medicine, Heidelberg, Germany
1976-1978
Department of Surgery, Division of Oncology, UCLA School of Medicine, Los Angeles, CA, tumor immunology
Academic and Administrative Appointments:
1978-1987
Associate Professor and Director, Research Laboratories
Departments of Obstetrics and Gynecologyand Pathology, University of Utah School of Medicine, Salt Lake City, UT
1987-1990
Professor (Tenure) and Chair
Department of Applied Medical Sciences, University of Southern Maine, Portland, ME; and Director of Reproductive Immunology, Foundation for Blood Research, Scarborough, ME
1990-2001
Professor (Tenure) and Chair
Department of Microbiology and Immunology; Professor of Obstetrics and Gynecology and Biological Sciences; and Associate Dean for Graduate Programs (2000-2001), School of Medicine and College of Science and Mathematics, Wright State University, Dayton, OH
2001-present
Professor (Tenure)
Departments of Reproductive Biology and Pathology, Case School of Medicine, Case Western Reserve University, Cleveland, OH
2001-present
Director, Division of Research
Department of Obstetrics and Gynecology, MetroHealth Medical Center (2001-2004) and Department of Obstetrics and Gynecology, MacDonald Women's Hospital, University Hospitals (2004-present)
2004-present
Vice Chair for Academic Affairs
Department of Obstetrics and Gynecology, MacDonald Women's Hospital, University Hospitals
Recent Publications:
Rote NS, Stetzer B. Autoimmune disease as a cause of reproductive failure. In Prenatal Testing, ed J. Canick, Clinics in Laboratory Medicine, 23:265-293, 2003. (PubMed)
Das M, Xu B, Lin L, Chakrabarti S, Shivaswamy V, Rote NS. Phosphatidylserine efflux and intercellular fusion in a BeWo model of human villous cytotrophoblast. Placenta, 25:396-407, 2004. (PubMed)
Rote NS, Chakrabarti S, Stetzer B. The role of endogenous retroviruses in human placental development. Placenta, 25:673-683, 2004. (PubMed)
González F, Minium J, Rote NS, Kirwan JP. Hyperglycemia alters tumor necrosis factor-a release from mononuclear cells in women with polycystic ovary syndrome. Journal of Clinical Endocrinology and Metabolism, 90:5336-5342, 2005. (PubMed)
González F, Minium J, Rote NS, Kirwan JP. Altered tumor necrosis factor-a release from mononuclear cells of obese reproductive age women during hyperglycemia. Metabolism 55:271-277, 2006. (PubMed)
González F, Rote NS, Minium J, Kirwan JP. Reactive oxygen species-induced oxidative stress in the development of insulin resistance and hyperandrogenism in polycystic ovary syndrome. Journal of Clinical Endocrinology and Metabolism, 91:336-340, 2006. (PubMed)
González F, Rote NS, Minium J, Kirwan JP. In vitro evidence that hyperglycemia stimulates tumor necrosis factor-a release in obese women with polycystic ovary syndrome. Journal of Endocrinology, 188:521-529, 2006. (PubMed)
González F, Rote NS, Minium J, Kirwan JP. Increased activation of nuclear factor ?B triggers inflammation and insulin resistance in polycystic ovary syndrome. Journal of Clinical Endocrinology and Metabolism, 91:1508-1512, 2006. (PubMed)
Alpin JD, Straszewski-Chavez SL, Kalionis B, Dunk C, Morrish D, Forbes K, Baczyk D, Rote N, Malassine A, Knofler M. Trophoblast differentiation: progenitor cells, fusion, and migration: A workshop report. In Trophoblast Research Placenta: From Molecule to Morphology to Mother. (eds F Lyall, G Desoye, K Shiverick), Elsevier Ltd., Amsterdam, Placenta (Suppl 1):141-143, 2006. (PubMed)
Recent Extramural Funding:
Antiphospholipid Antibody Heterogeneity, July 1, 2003 – April 30, 2008, NIH, RO1 HD043566, PI: Neal S. Rote
Antibody-directed Targeting of Ovarian Cancer Blood Vessels, March 15, 2006 – March 14, 2008, OROC (Out Run Ovarian Cancer) Advocacy and Research Group
PI: Neal S. Rote, Co-Investigators: Vivian von Gruenigen, M.D., Steven Waggoner, M.D.
Placental Endogenous Retrovirus Expression, February 1, 2003 – January 31, 2006, RO3 HD043546, PI: Neal S. Rote
Antiphospholipid Antibodies and Pregnancy Loss, August 1, 1988 - March 31, 2003, RO1 HD23697, PI: Neal S. Rote
