case western reserve university


MacDonald Women's Hospital  
University Hospitals  
Case Medical Center


Sam Mesiano , Ph.D.
Assistant Professor


Office Location:
MacDonald 8009A
Office Phone:
(216) 844-1553
Lab Location:
MacDonald 8009
Lab Phone:
(216) 844-1553

(Download CV)

Research Interests:
  The physiology of human parturition and the timing of birth.
The role of estrogens and progesterone in the control of myometrial contractility.
The evolutionary biology of human birth timing.
  Recent Publications:

Mesiano S (2001) Role of estrogen and progesterone in human parturition. In Smith R (ed): "The Endocrinology of parturition. Basic science and clinical application". Front Horm Res. Basel, Karger Vol 27, pp 86-104 (PubMed)

Mesiano S, Chan E-C, Fitter JT, Kwek K, Yeo G, Smith R (2002) Progesterone withdrawal and estrogen activation in human parturition are coordinated by progesterone receptor-A expression in the myometrium. J Clin Endocrinol Metab 87:2924-2930 (PubMed)

Madsen G, Zakar T, Ku CY, Sanborn BM, Smith R, Mesiano S (2004) Prostaglandins differentially modulate progesterone receptor-A and -B expression in human myometrial cells: Evidence for prostaglandin-induced functional progesterone withdrawal. J Clin Endocrinol Metab. 89(2):1010-1013 [PubMed)

Mesiano S (2004) Myometrial progesterone responsiveness and the control of human parturition. J Soc Gynecol Invest 1(4):193-202 (PubMed)

Madsen M, Zakar T, Manuelpillai U, Wallace U, Kwek K, Yeo GSH, Smith R, Mesiano S (2004) Intracrine control of estrogen action in human gestational tissues at parturition. J Soc Gynecol Invest 11(4):213-219 (PubMed)

Bisits AM, Smith R, Mesiano S, Yeo GSH, Kwek K, MacIntyre DA, Chan EC (2005) Inflammatory aetiology of human myometrial activation demonstrated using directed graphs. PLoS Computational Biology 1(2) e19: 132-136 (PubMed)


Sam Mesiano recieved a BSc (Hons) in biochemistry and physiology in 1982 at Monash University, Australia and in 1988 obtained a PhD in physiology at the same institution. His dissertation research involved a detailed study of the role of IGFs in the hormonal control of growth in the fetal lamb. Dr Mesiano was then awarded a WM Keck postdoctoral fellowship in molecular endocrinology in the laboratory of Dr Robert Jaffe in the Reproductive Endocrinology Center at the University of California, San Francisco where he studied the development and functional biology of the human fetal adrenal cortex. After completing a postdoctoral fellowship he remained at UCSF as a staff scientist (1992-1995) and then faculty member until 1998. During that time he was a co-investigator on 2 NIH-funded grants, co-supervised 12 Reproductive Endocrinology/Infertility fellows. His studies were in the areas of 1) human fetal adrenal development and function, 2) the control of angiogenesis in the human fetus, the adult female reproductive tract and in the progression of ovarian cancer, and 3) the role of phytoestrogens in the regulation of adrenal steroidogenesis. In 1998 Dr Mesiano moved to the University of Newcastle, Australia where he was a principal investigator in the Mothers and Babies Research Centre with funding from the National Health and Medical Research Council of Australia. During his tenure at the University of Newcastle Dr Mesiano continued to study the role of steroid hormones in the control of human pregnancy and parturition. In 2004 he left Newcastle to take up a faculty position in the Department of Reproductive Biology at CWRU where he continues to explore the hormonal control of human parturition.