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Associate Professor of Psychiatry,
CWRU
Director of Psychiatry Research, LSC-VAMC
Office Phone: 440-526-3030
ext 6846
gxj5@case.edu
Office Location: 10000 Brecksville Road | Brecksville,
Ohio 44141
Medical School
University of Toronto, Canada
Residency
Massachusetts Mental Health
Center, Boston (Adult Psychiatry)
Fellowship
Clinical Brain Disorders
Branch, National Institutes of Mental Health, Bethesda,
Maryland
Board Certification
Adult Psychiatry and ABPN
Special Interests
Schizophrenia, Psychoses,
Dopamine, Prefrontal Cortex, Antipsychotic Drugs, Tyrosine
and Phenylalanine
Research Projects
Comparison of Generic Clozapine
with Clozaril® in Stable Clozapine Maintenance Patients
Comparing Amino Acid Concentrations
in Serum and Cerebrospinal Fluid
Tyrosine Augmentation of
Clozapine-Induced Dopamine Release in the Prefrontal Cortex
of the Rat
Association Memberships
Society for Neuroscience
National Association for Veterans Affairs Physicians and
Dentists
Ukrainian Medical Association of North America
Advisory Board: National Alliance for the Mentally Ill
(Cleveland)
Advisory Board: PLAN of Northeast Ohio
Publications
1. Jaskiw,
G.E., Popli, A., A meta-analysis of the response to chronic
L-dopa in patients with schizophrenia: Therapeutic and
heuristic implications. Psychopharmacol. 171:365-74, 2004.
2. Jaskiw,
G.E., Simpson, C., Bongiovanni, R., Yamamoto, B.K., Tyrosine
augments clozapine-induced dopamine release in the medial
prefrontal cortex of the rat in vivo: effects of access
to food. Neurosci. Lett. 357:5-8, 2004.
3. Jaskiw,
G.E., Bongiovanni, R. Brain tyrosine depletion attenuates
haloperidol-induced striatal dopamine release in vivo
and augments haloperidol-induced catalepsy. Psychopharmacol.
172:100-107, 2004.
4. Jaskiw,
G.E., Hussain, G., Stephans, S.E., Yamamoto, B.K., Meltzer,
H.Y., Clozapine prolongs immobility in rats with bilateral
6-hydroxydopamine lesions of the striatum. Neurosci. Lett.
362:35-38, 2004.
5. Jaskiw,
G.E., Thyrum, P.T., Fuller, M.A., Arvanitis, L.A., Yeh,
C. A study of the pharmacokinetics of quetiapine fumarate
in elderly individuals with selected psychotic disorders.
Clin. Pharmacokinet. 43:1025-35, 2004.
6. Jaskiw,
G.E., Kirkbride, B., Newbould, E., Young, D., Durkalski,
V., Bongiovanni, R. Clozapine-induced dopamine release
in the medial prefrontal cortex is augmented by a moderate
concentration of locally administered tyrosine but attenuated
by high tyrosine concentrations or by tyrosine depletion.
Psychopharmacol. 179:713-24, 2005.
7. Bongiovanni,
R., Kirkbride, B., Walmire, P., Jaskiw, G.E.,. Tyrosine
administration does not affect desipramine-induced dopamine
levels as measured in vivo in prefrontal cortex. Brain
Res. 1054:203-6, 2005.
8. Jaskiw,
G.E., Kirkbride, B., Bongiovanni, R. In rats chronically
treated with clozapine, tyrosine depletion attenuates
the clozapine-induced in vivo increase in prefrontal cortex
dopamine and norepinephrine levels. Psychopharmacol. 185:416-422,
2006. |
