tation of REDCap across COIN for data capture, data management, information integration, report generation, and evaluation.

The Cleveland CTSA’s BRIM Core manages COIN’s shared IT and informatics resources, data capture tools, communications tools, and data security needs. Utilizing BRIM’s resources, the COIN Coordinating Center harnesses cutting-edge informatics resources readily available or easily adaptable from existing CTSA infrastructure. Tools for communication, training, project management, data capture, and reporting are made available, creating and providing both public and password-protected web-site for local and statewide COIN activities (exclusive of protected health information). A Content-Management-System framework in a wiki environment such as Semantic Mediawiki is used to allow for delegating control of different content areas to designated individuals across the network. Other communication venues include online blogs, an events calendar, and news updates. For task orders, the BRIM Core will deploy and implement REDCap for data capture, information integration, report generation and evaluation.

The Governor’s Health Corridor initiative also builds on ongoing work to develop interoperable platforms for sharing de-identified clinical data for research purposes. This includes the work of each CTSA’s BRIM Core and the Regional Extension Centers to develop data sharing platforms, and the work of Explorys to share data across a rapidly expanding web of collaborating clinical site. Explorys is an electronic tool that enables rapid search and retrieval of information from electronic health records from different systems, and is described in the following section. The development of interoperable informatics platforms is an area of considerable investment and growth across the institutions, and the Governor’s initiative and a strong collaborative spirit among the CTSA leaders will make this an area of rapidly increasing capacity for Ohio PBRNs. Under the Governor’s Health Corridor Initiative, shared data agreements are being aggressively negotiated among the partnering institutions. Below we describe existing informatics resources that are available to COIN. Each CTSA has an Informatics Shared Resource that is engaged in advancing shared data use agreements.

To support communication across the COIN consortium the Coordinating Center is working with NetWellness to expand its ability to serve as a portal for COIN, providing information and resources for PBRN directors and members alike in support of the development, implementation and dissemination goals of the COIN consortium and its members.

To respond to AHRQ FOAs, we will use COIN’s inter-institutional information technology resources in two ways. First, to quickly determine feasibility of studies (e.g. to determine if there are enough diabetics of a certain age and number of co-morbidities) we will provide a rapid turn-around query to Explorys and to the relevant healthcare system IT organizations described below. Using de-identified data, these often can be turned around within several working days. In order to conduct specific projects, IT experts who can access and manage inter-institutional data available through Explorys and healthcare system data available through the CTSAs’ Biomedical Research Informatics Management (BRIM) Core will be engaged as co-investigators in FOA proposals. For more minor data needs, these Cores will be paid on a contract basis for data retrieval services.

Inter-Institutional Dissemination & Implementation Resources

Each partner has strong working relationships with a number of community organizations involved in enhancing health care and health in their region of Ohio. For the three of the sites, these are supported by the community engagement arm of their CTSAs. In addition, the Cleveland and Cincinnati are sites for the Robert Wood Johnson Foundation Aligning Forces for Quality (AF4Q) initiative (described above under each site). These initiatives bring together diverse health care partners to share health care quality data across the region, and to work together in learning collaboratives and with multi-stakeholder groups to improve the quality of health care. These initiatives provide a powerful platform for dissemination and implementation of PBRN findings at the level of the local primary care practice, multiple healthcare systems, and the community.

A unique dissemination, implementation and research support engine is provided by NetWellness (www.netwellness.org). Launched in 1995, NetWellness was one of the first consumer health sites on the internet. A partnership of CWRU, OSU and UC, NetWellness offers understandable health information for a general audience. The partnership uniquely provides an internet environment and program support for faculty members to participate, sharing up-to-date information from their field of specialty. Tapping into the intrinsic mission of universities to educate, NetWellness has succeeded as a valued non-profit resource, serving a national and international audience, receiving over 13 million visitors per year. More than 66,000 questions have been answered to date through its Ask-an-Expert Service. The inclusion of PBRN members and leaders, and CTSC faculty make this a unique and vital mechanism to foster implementation and dissemination of PBRN Research.

NetWellness provides a communications platform for PBRNs and their academic partners. CTSA and NetWellness partners are developing an in-depth, web-based research center. The content is being designed to demystify and illuminate research is in a way that a general audience can understand. Descriptions and examples will demonstrate the guiding research objective of improved health, and describe how people can participate at all levels of the research process. Content will illustrate how medical science evolves from basic science to clinical studies and the safeguards in place throughout that process. Content on translational research will be featured, highlighting how this approach makes a difference in taking results to the community. Accessible, person-centered content provided by faculty experts will help build trust in the research itself. The site will serve as a resource for research education materials that can be reproduced for community-based outreach activities and as ongoing, comprehensive information available online at any time. Because the information is web-based and interactive through e.g. an “ask-an-expert” service, the site can be an asset for long-term relationship-building for CTSA universities, PBRN members and researchers.