Pathomechanisms of TDP-43 in neurodegeneration:
Genetic mutations in TAR DNA-binding protein 43 (TDP-43) cause ALS and FTD, and the increased presence of TDP-43 in the cytoplasm is a prominent histopathological feature of degenerating neurons in AD, PD, FTD and ALS. One major focus of our current research is about the molecular pathomechanisms of TDP-43 in various major neurodegenerative diseases including but not limited to AD, PD, FTD and ALS.
Mitochondrial dysfunction in neurodegeneration:
Mitochondrial dysfunction has long been recognized as a prominent feature of AD, PD, FTD and ALS. However, the mechanisms responsible for the mitochondrial impairment, and its role in these diseases were not clear. Mitochondria are dynamic organelles that undergo continual fission and fusion events which serve crucial physiological function. Another focus of our research is the potential role of mitochondria dynamics in mitochondrial dysfunction and neurodegeneration in AD, PD, FTD and ALS.