2017

Wang, X, Zhang., Q, Bao, R., Zhang, N., Wang, Y., Polo-Parada, L., Tarim, A., Alemifar, A. Han, X., Wilkins, H.M., Swerdlow, R.H., Wang, X. and Ding, S. (2017) Deletion of Nampt in Projection Neurons of Adult Mice Leads to Motor Dysfunction, Neurodegeneration, and Death. Cell Reports. 20(9):2184-2200.

Siedlak, S.L., Jiang, Y., Huntley, M.L., Wang, L., Gao, J., Xie, Fei., Liu, J., Su, B., Perry, G. and Wang, X. (2017) TMEM230 Accumulation in Granulovacuolar Degeneration Bodies and Dystrophic Neurites of Alzheimer’s Disease. J Alzheimers Dis. 58(4):1027-1033.

Gu, J., Chen, F., Iqbal, K., Gong, C.X., Wang, X. and Liu, F. (2017) Transactive response DNA-binding protein 43 (TDP-43) regulates alternative splicing of tau exon 10: implications for the pathogenesis of tauopathies. J Biol Chem. 292(25):10600-10612.

Gu, J., Wu, F., Xu, W., Shi, J., Hu, W., Jin, N., Qian, W., Wang, X., Iqbal, K., Gong, C.X. and Liu, F. (2017) TDP-43 suppresses tau expression via promoting its mRNA instability. Nucleic Acids Res. 45(10):6177-6193.

Wang, W., Arakawa, H., Wang, L., Okolo, O., Siedlak, S.L., Jiang, Y., Gao, J., Xie, F., Petersen, R.B. and Wang, X. (2017) Motor coordination and cognitive dysfunction caused by mutant TDP-43 could be reversed by inhibiting its mitochondrial localization. Mol Ther. 25(1):127-39. Comment on: “New Therapeutic Avenue for ALS: Avoiding a Fatal Encounter of TDP-43 at the Mitochondria” in Mol Ther. 2017, 25(1), 10–11.

2016

Wang, W., Wang, L., Lu, J., Siedlak, S.L., Fujioka, H., Liang, J., Jiang, S., Ma, X., Zhen, J., Rocha, E.L., Sheng, M., Choi, H., Lerou, P.H., Li, H., and Wang, X. (2016). The Inhibition of TDP-43 Mitochondrial Localization Blocks Its Neuronal Toxicity. Nature Medicine. 22(8):869-78. Comment on: “Unleashed From the Nucleus, TDP-43 Wreaks Havoc in Mitochondria” in ALZFORUM; “From the Bench: TDP-43 Accumulation in Mitochondria May Drive ALS/FTD Toxicity” in Neurology Today, 2016, 16(17):42–44; “ALS Culprit Protein Chokes Mitochondria, Killing Neurons, According to Recent Discovery” in ALS NEWS TODAY; “Protein’s Misconduct in Mitochondria May Be Cause of Nerve Cell Death in Huntington’s” in the Huntington’s Disease News; “Scientists Prevent Nerve Cell Death and Neurodegenerative Disease Progression” in Kerafast; “Scientists keep a molecule from moving inside nerve cells to prevent cell death” by Case Western Reserve University School of Medicine.

Wang, W., Wang, X.*, Fujioka, H., Hoppel, C., Whone, A.L., Caldwell, M.A., Cullen, P.J., Liu, J.* and Zhu, X.* (2016). Parkinson's disease-associated mutant VPS35 causes mitochondrial dysfunction by recycling DLP1 complexes. Nature Medicine. 22(1):54-63. *corresponding author.

Wang, C., Zhang, F., Jiang, S., Siedlak, S., Shen, L., Perry, G., Wang, X., Tang, B. and Zhu, X. (2016) Estrogen receptor-α is localized to neurofibrillary tangles in Alzheimer's disease. Scientific Reports. 6:20352.

2015

Wang, W., Zhang, F., Li, L., Tang, F, Siedlak, S. L., Liu, Y., Su, B., Fujioka, H. and Wang, X. (2015) Mfn2 Couples Glutamate Excitotoxicity and Mitochondrial Dysfunction in Motor Neurons. J Biol Chem., 290:168-82. “Paper of the Week”.

Zhang, F., Su, B., Wang, C., Siedlak, S.L., Mondragon-Rodriguez, S., Lee, Hyoung-gon., Wang, X., Perry, G. and Zhu, X. (2015) Posttranslational Modifictions of α-Tubulin in Alzheimer Disease. Transl. Neurodegener. 4:9.

Zhang, F., Wang, W., Siedlak, S., Liu, Y., Liu, J., Jiang, K., Perry, G., Zhu, X., and Wang, X. (2015) Miro1 Deficiency in Amyotrophic Lateral Sclerosis. Front Aging Neurosci. 7:100.

Zhang, B., Cowden, D., Zhang, F., Yuan, J., Siedlak, S., Abouelsaad, M., Zeng, L., Zhou, X., O'Toole, J., Das, A.S., Kofskey, D., Warren, M., Bian, Z., Cui, Y., Tan, T., Kresak, A., Wyza, R.E., Petersen, R.B., Wang, G.X., Kong, Q., Wang, X., Sedor, J., Zhu, X., Zhu, H., Zou, W.Q.. (2015) Prion Protein Protects against Renal Ischemia/Reperfusion Injury. PLoS One. 10(9):e0136923.

Blair, J.A., Palm, R., Chang, J., McGee, H., Zhu, X., Wang, X. and Casadesus, G. (2015) Luteinizing hormone downregulation but not estrogen replacement improves ovariectomy-associated cognition and spine density loss independently of treatment onset timing. Horm Behav. 78:60-66.

Jiang, Z., Wang, W., Perry, G., Zhu, X and Wang, X. (2015) Mitochondrial dynamic abnormalities in amyotrophic lateral sclerosis. Transl. Neurodegener. 4:14.


2014

Hwang, R.D., Wiemerslage, L., LaBreck, C.J., Khan, M., Kannan, K., Wang, X., Zhu, X., Lee, D. and Fridell, Y.W. (2014) The neuroprotective effect of human uncoupling protein 2 (hUCP2) requires cAMP-dependent protein kinase in a toxin model of Parkinson's disease. Neurobiol Dis. 69C:180-91.

Li, L., Wang, W., Welford, S., Zhang, T., Wang, X. and Zhu, X. (2014) Ionizing radiation causes increased tau phosphorylation in primary neurons. J Neurochem. 131:86-93.

Wang, X.*, Wang, W., Li, L., Perry, G., Lee, H.G., Zhu, X.* (2014) Oxidative Stress and Mitochondrial Dysfunction in Alzheimer's Disease. Biochim Biophys Acta. 8:1240-47. *corresponding author

Bonda, D.J., Wang, X., Lee, H.G., Smith, M.A., Perry, G. and Zhu, X. (2014) Neuronal failure in Alzheimer's disease: a view through the oxidative stress looking-glass. Neurosci Bull. 30:243-52.


2013

Wang, W., Li, L., Lin, W., Dickson, D. W., Petrucelli, L. and Wang, X. (2013) The ALS disease associated mutant TDP-43 impairs mitochondrial dynamics and function in motor neurons. Hum Mol Genet, 22:4706-19.

Zhu, X, Perry, G, Smith, M.A., Wang, X. (2013) Abnormal Mitochondrial Dynamics in the Pathogenesis of Alzheimer's Disease. J Alzheimers Dis. 33 Suppl 1, S253-62.

Yan, M.H., Wang, X, Zhu X. Mitochondrial defects and oxidative stress in Alzheimer disease and Parkinson disease. (2013) Free Radic Biol Med. 62, 90-101.

2012

Sheng, B., Wang, X., Su, B., Lee, H.G., Casadesus, G., Perry, G., Zhu, X. (2012) Impaired Mitochondrial Biogenesis Contributes to Mitochondrial Dysfunction in Alzheimer's Disease. J. Neurochem. 120(3):419-29.

Kudo, W., Lee, H.P., Zou, W.Q., Wang, X., Perry, G., Zhu, X., Smith, M.A., Petersen, R.B., Lee, H.G. (2012) Cellular Prion Protein Is Essential for Oligomeric Amyloid-β-Induced Neuronal Cell Death. Hum Mol Genet. 21(5):1138-44.

Liu, K., Guo, T.L., Chojnacki, J., Lee, H., Wang, X., Siedlak, S.L., Rao, W., Zhu, X., Zhang, S. (2012) Bivalent ligand containing curcumin and cholesterol as fluorescence probe for Aβ plaques in Alzheimer's disease. ACS Chemical Neuroscience , 3:141−146.

Wang, X.*, Yan, M., Fujioka, H., Liu, J., Wilson-Delfosse, A., Chen, S., Perry, G., Casadesus, G., Zhu, X.* (2012) LRRK2 Regulates Mitochondrial Dynamics and Function through Direct Interaction with DLP1. Hum Mol Genet. 21:1931-44. *corresponding author

Lee, H.P., Pancholi, N., Esposito, L., Previll, L.A., Wang, X., Zhu, X., Smith, M.A., Lee HG. (2012) Early induction of oxidative stress in mouse model of Alzheimer disease with reduced mitochondrial superoxide dismutase activity. PLoS One. 7:e28033.

Wang, X.*, Snape, M., Klann, E., Stone, J.G., Singh, A., Petersen, R.B., Castellani, R.J., Casadesus, G. Smith, M.A., Zhu, X.* (2012) Activation of the extracellular signal-regulated kinase pathway contributes to the behavioral deficit of fragile x-syndrome. J. Neurochem. 121:672-9. *corresponding author

Wang, X.*, Petrie, T.G., Liu, Y., Liu, J., Fujioka, H., Zhu, X.* (2012) Parkinson's Disease-Associated DJ-1 Mutations Impair Mitochondrial Dynamics and Cause Mitochondrial Dysfunction. J Neurochem. 121:830-9. *corresponding author

Rodrigues, R., Smith, M.A., Wang, X., Perry, G., Lee, H., Zhu, X. and Petersen, R.B. (2012) Molecular neuropathogenesis of Alzheimer’s disease: an interaction model stressing the central role of oxidative stress, Future Neurology 7, 287-305.


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