Wei Xin, M.D., Ph.D.

Assistant Professor

Mailing Address:
2103 Cornell Rd.
WRB 5525
Cleveland, OH 44106-7288

phone: (216) 844-4976
fax: (216) 368-0494
email: Wei.Xin@Case.edu

Biography
Dr. Wei Xin graduated from Shanghai Medical University (1991) and finished his urology residency in Shanghai First People's hospital. Then he came to USA to study molecular mechanism of hepatitis B virus and subsequently received a PhD from the State University of New York at Buffalo (1998).

Dr. Wei Xin received his AP/CP pathology training in University of Michigan, Ann Arbor. He also completed his fellowship training of surgical pathology with subspecialty of GI/liver pathology in University of Michigan, in addition, he also received pancreatic pathology training in GI/liver division of Johns Hopkins University. During his training period, he presented twelve times in national meetings sponsored by United States and Canadian Society of Anatomical Pathologists, the American Society of Clinical Pathologists/College of American Pathologists and American Urology Association. He also authored/co-authored many papers in peer reviewed journals. He also received Rodger C. Haggitt GI Pathology Society award for best resident presentation (2003), and M.R. Abell House Officer Award for the outstanding and exemplary achievement in the discipline of pathology (2004).

Before Dr. Xin joined the faculty as assistant professor at Case Western Reserve University, he was the faculty of the Department of Pathology as lecturer in University of Michigan and served as the GI pathologist and associated medical director of Acupath Laboratory Inc (Plainview, NY).

Research
Dr. Xin's current research interests are non-neoplastic GI disease and GI tract neoplasm especially pancreatic tumors, hepatomas and gastric tumors.

Publications
Chaoyang Li, Shuiliang Yu, Jinghua Xu, Amber A Petrolla, Fumihiko Nakmura, Shaoman Yin, Neena Singh, Thomas Stossel, Alan Tartakoff, Derek Abbot, Wei Xin* and Man-sun Sy*. Binding of Prion Pro-protein to Filamin A Disrupts Cytoskeletal organization and Signaling that Provides Growth Advantage to Human Pancreatic Ductal Carcinomas. Journal of Clinical Investigation, (accepted, 6/2009)
*shared senior authorship

Amber A Petrolla, Jeffrey A Katz and Wei Xin. The Clinical Significance of Focal Enhanced Gastritis in Adults with Isolated Terminal Ileitis, Journal of Gastroenterology; 2008;43(7):524-30.

Amber A Petrolla and Wei Xin. Hepatic Angiomyolipoma. Archives of Pathology and Laboratory Medicine, 2008 Oct;132(10):1679-82.

Wei Xin and Joel K. Greenson. (2004) The Clinical Significance of Focally Enhanced Gastritis. American Journal of Surgical Pathology. 28(10):1347-1351.

Wei Xin, Kim J. Yun, Francesca Ricci, Marianna Zahurak, Wanglong Qiu, Gloria H. Su, Charles J. Yeo, Scott E. Kern, Ralph H. Hruban and Christine A. Iacobuzio-Donahue. (2004) Evaluation of MKK4 Expression in Pancreatic Cancer using Tissue Microarray Technology: Relationship to Genetic status, Metastasis and Prognosis. Clinical Cancer Research, 10: 8516-8520.

Yasunori Ogura, Sanja Lala, Wei Xin, Elisabeth Smith, Theresa A. Dowds, Felicia F. Chen, Ellen Zimmermann, Maria Tretiakova, Judy Cho, John Hart, Joel Greenson, Satish Keshav and Gabriel Nuñez. (2003). Expression of NOD2 in Panneth Cells: A Possible Link to Crohn's Ileitis. Gut. 52:1591-1597.

Wei Xin, Pamela I Brown and Joel K Greenson (2003). The Clinical Significance of Focal Active Colitis in Pediatric Patients. The American Journal of Surgical Pathology. 27(8): 1134-1138.

Wei Xin and Claire W. Michael. The Exaggerated Pigmented Granulomatous Reaction to the Artificial Joint Implant Mimics Metastatic Melanoma (2004). Diagnostic Cytopathology. 30(3):198-200.

Wei Xin, Stephen Raab and Claire Michael. Low Grade Urothelial Carcinoma: Reappraisal of the Cytologic Criteria on ThinPrep© (2005). Diagnostic Cytopathology. 29(3):125-129.

Wei Xin, Saravana M. Dhanasekaran, Collette Ingold, Kenneth J. Pienta, Arul M. Chinnaiyan and Mark A. Rubin (2003). Dysregulation of Selected Annexin Family Proteins is Associated with Prostate Cancer Progression. The American Journal of Pathology. 162(1): 255-61.

Wei Xin, Mark A Rubin and Paul E. McKeever. The Differential Expression Patterns of Cytokeratins 8 and 20 Distinguish Craniopharyngioma and Rathke Cleft Cyst (2002). Archives of Pathology and Laboratory Medicine. 126(10): 1174-1178.

Wei Xin and Augusto F. Paulino. Prognostic Factors in Malignant Mixed Tumors of Salivary Gland: Correlation of Immunohistochemical Markers with Histologic Classification (2002). Annals of Diagnostic Pathology. 6(4): 205-210.

Wei Xin and Jui H. Wang (1998). Antisense Inhibition of Duck hepatitis B Virus by Poly-DNP- oligonucleotides" Antisense and Nucleic acid Drug Development. 8(6): 459–468.