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Joseph E. Willis, M.D.

Associate Professor

Mailing Address:
11100 Euclid Ave.
Cleveland, OH 44106

phone: (216) 844-8292
email: Joseph.Willis@Case.edu

Biography

1982 M.B. B.Ch. B.A.O., University College, Cork, Ireland
1986 F.R.C.S.I., Fellowship of the Royal College of Surgeons in Ireland
1987-1988 Research Fellow in the Department of Surgery, State University of New York, Buffalo, New York
1988-1992 Residency training in a combined AP/CP Pathology Program, University of Rochester, New York
1991-1992 Chief Resident, Department of Pathology, University of Rochester, New York
1992-1993 Fellow in Surgical Pathology, University of Michigan, Ann Arbor, Michigan
1993 American Board of Pathology - Combined Anatomic Pathology and Clinical Pathology
1993-2001 Assistant Professor, Department of Pathology, Institute of Pathology, Case Western Reserve University, Cleveland, Ohio
1997 American Board of Pathology - Cytopathology Subspecialty Board
2001-present Associate Professor, Department of Pathology, Institute of Pathology, Case Western Reserve University, Cleveland, Ohio
2004-present Director, Tissue Management, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio
2005-present Vice Chair of Pathology for Clinical Affairs, UH Case Medical Center/Case Western Reserve University, Cleveland, Ohio


Research

Gastrointestinal Pathology - investigating basic mechanisms of development and prognostic factors relating to gastro-intestinal neoplasms.

Publications

Aberrant vimentin methylation is characteristic of upper gastrointestinal pathologies.
Moinova H, Leidner RS, Ravi L, Lutterbaugh J, Barnholtz-Sloan JS, Chen Y, Chak A, Markowitz SD, Willis JE.
Cancer Epidemiol Biomarkers Prev. 2012 Apr;21(4):594-600.

Variation in age at cancer diagnosis in familial versus nonfamilial Barrett's esophagus.
Chak A, Chen Y, Vengoechea J, Canto MI, Elston R, Falk GW, Grady WM, Guda K, Kinnard M, Markowitz S, Mittal S, Prasad G, Shaheen N, Willis JE, Barnholtz-Sloan JS.
Cancer Epidemiol Biomarkers Prev. 2012 Feb;21(2):376-83. doi: 10.1158/1055-9965.EPI-11-0927.

Aberrantly methylated PKP1 in the progression of Barrett's esophagus to esophageal adenocarcinoma.
Kaz AM, Luo Y, Dzieciatkowski S, Chak A, Willis JE, Upton MP, Leidner RS, Grady WM.
Genes Chromosomes Cancer. 2012 Apr;51(4):384-93.

Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance.
Zhou D, Zhang Y, Wu H, Barry E, Yin Y, Lawrence E, Dawson D, Willis JE, Markowitz SD, Camargo FD, Avruch J.
Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):E1312-20. 31.

Image analysis for classification of dysplasia in Barrett's esophagus using endoscopic optical coherence tomography.
Qi X, Pan Y, Sivak MV, Willis JE, Isenberg G, Rollins AM.
Biomed Opt Express. 2010 Sep 9;1(3):825-847