Xinglong Wang, Ph.D.


Mailing Address:
2103 Cornell Rd.
WRB 5101
Cleveland, OH 44106-7288

phone: (216) 368-6708
fax: (216) 368-0494

Dr. Wang received his Ph.D. in pathology from the Case Western Reserve University in 2009. Following postdoctoral training at the Department of Pathology, he was promoted to Instructor of Pathology in 2011.

My research interest is to understand the mechanism(s) underlying neuronal death in neurodegenerative diseases. The major focus of my current work is the mechanisms underlying mitochondrial dysfunction in Alzheimer's (AD) and Parkinson's disease (PD). Mitochondrial dysfunction has long been recognized as a prominent feature of both AD and PD. However, the mechanisms responsible for the mitochondrial impairment, and its role in these diseases were not clear. Recent studies in the field of basic research on mitochondria reveal that they are dynamic organelles that undergo continual fission and fusion events which serve crucial physiological function. Riding on this recent tide of extensive characterization of mitochondrial dynamics, studies are underway to investigate the role of mitochondria dynamics in the pathogenesis of AD and PD. Specific questions include: Whether and how disease-associated genetic factors affects mitochondrial dynamics and function; whether and how alterations in mitochondrial dynamics cause disease-relevant changes; How we target mitochondrial dynamics for therapeutic development?