Xinglong Wang, Ph.D.Assistant Professor
2103 Cornell Rd.
Cleveland, OH 44106-7288
phone: (216) 368-2957
fax: (216) 368-0494
Dr. Wang received his Ph.D. in pathology from the Case Western Reserve University in 2009. Following postdoctoral training at the Department of Pathology, he was promoted to Instructor of Pathology in 2011 and has became an Assistant Professor in 2013.
My research interest is to understand the mechanism(s) underlying neuronal death in neurodegenerative diseases. The major focus of my current work is the mechanisms underlying mitochondrial dysfunction in Amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD) and Parkinson's disease (PD). Mitochondrial dysfunction has long been recognized as a prominent feature of ALS, AD and PD. However, the mechanisms responsible for the mitochondrial impairment, and its role in these diseases were not clear. Recent studies in the field of basic research on mitochondria reveal that they are dynamic organelles that undergo continual fission and fusion events which serve crucial physiological function. Riding on this recent tide of extensive characterization of mitochondrial dynamics, studies are underway to investigate the role of mitochondria dynamics in the pathogenesis of ALS, AD and PD. Specific questions include: Whether and how disease-associated genetic factors affects mitochondrial dynamics and function; whether and how alterations in mitochondrial dynamics cause disease-relevant changes; How we target mitochondrial dynamics for therapeutic development?
See publication list at http://scholar.google.com/citations?hl=en&user=3zTNjfcAAAAJ&view_op=list_works&sortby=pubdate
1. Wang X, Su B, Fujioka H, Zhu X, DLP1 reduction underlies mitochondrial morphology and distribution abnormalities in fibroblasts from sporadic Alzheimer disease patients. Am J Pathol., 173, 470-482, 2008. PMCID: PMC2475784.
2. Wang X, Su B, Siedlak S, Moreira PI, Fujioka H, Wang Y, Casadesus G, Zhu X, Aβ Overproduction Causes Abnormal Mitochondrial Dynamics via Modulation of Mitochondrial Fission/Fusion Proteins. Proc Natl Acad Sci USA, 105, 19318-19323, 2008. PMCID: PMC2614759.
3. Wang X, Su B, Lee H, Li X, Perry G, Smith MA, Zhu X, Impaired balance of mitochondrial fission and fusion in Alzheimer’s disease. J Neurosci., 29, 9090-9103, 2009. PMCID: PMC2735241.
4. Wang, X., Perry, G., Smith, M.A. Zhu, X., Amyloid-β-Derived Diffusible Ligands Cause Impaired Axonal Transport of Mitochondria in Neurons. Neurodegenerative Dis. 13, 56-59, 2010. PMCID: PMC2859232.
5. Bevilacqua, E., Wang, X., Majumder, M., Gaccioli, F., Yuan, C.L., Zhu, X., Jordan, L.E., Scheuner, D., Kaufman, R.J., Koromilas, A.E., Snider, M.D., Holcik, M. and Hatzoglou, M. (2010) eIF2alpha Phosphorylation Tips The Balance To Apoptosis During Osmotic Stress. J Biol Chem. 285(22):17098-111. PMCID: PMC2878040
6. Wang, X., Su, B., Gao, Y., Perry, G., Smith, M.A. and Zhu, X., DLP1-Dependent Mitochondrial Fragmentation Mediates 1-methyl-4-phenylpyridinium Toxicity in Neurons: Implications for Parkinson’s Disease. Aging Cell. 10, 807-823, 2011. PMCID: PMC3173562
7. Wang, X., Petrie, T.G., Liu, Y., Liu, J., Fujioka, H., Zhu, X., Parkinson's Disease-Associated DJ-1 Mutations Impair Mitochondrial Dynamics and Cause Mitochondrial Dysfunction. J Neurochem. 121, 830-839, 2012. PMCID: PMC3740560
8. Wang, X., Yan, M., Fujioka, H., Liu, J., Wilson-Delfosse, A., Chen, S., Perry, G., Casadesus, G., Zhu, X., LRRK2 Regulates Mitochondrial Dynamics and Function through Direct Interaction with DLP1. Hum Mol Genet. 21, 1931-1944, 2012. PMCID: PMC3315202
9. Wang, W., Li, L., Lin, W., Dickson, D. W., Petrucelli, L. and Wang, X. The ALS disease associated mutant TDP-43 impairs mitochondrial dynamics and function in motor neurons. Hum Mol Genet, 22:4706-19, 2013. PMCID: PMC3820133