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Alan M. Tartakoff, Ph.D.ProfessorMailing Address: fax: (216) 368-0494 email: Alan.Tartakoff@Case.edu |
Biography
| 1965 | B.A., Biology, Harvard University, Massachusetts (Kafatos) |
| 1973 | Ph.D., Cell Biology, Rockefeller University, New York, New York (Palade) |
| 1973-1981 | Postdoctoral Fellow, Department of Pathology, University of Geneva, Switzerland (Vassalli) |
| 1981-1983 | Maitre d'Enseignement et de Recherche (Associate Professor with tenure), University of Geneva |
| 1984-1988 | Associate Professor, Department of Pathology, Case Western Reserve University, Cleveland, Ohio |
| 1988-1993 | Professor, Department of Pathology, Case Western Reserve University, Cleveland, Ohio |
| 1993-1994 | Visiting Professor in Yeast Molecular Genetics (B.Dujon), Pasteur Institute, Paris, France |
| 1994-present | Professor, Department of Pathology, Case Western Reserve University, Cleveland, Ohio; Director, Cell Biology Program, CWRU |
Research
The laboratory is presently focused on 1) cell biology of the yeast nucleus, and 2) the development of
novel methods to identify synthetic genetic relations in yeast and animal cells. The former studies
emphasize the importance of the nuclear lamina for determining the shape of the nucleus, as well as
the sequential remodeling of the nucleus which occurs during anaphase. The latter studies focus on a
signaling path in yeast (the Arrest of Secretion Response), the identification of cDNAs which affect
the impact of the mutant huntingtin protein (which is characteristic of Huntington's Disease), and
the migration of tumor cells and lymphocytes, in vivo.
Publications
Kadowaki T, Goldfarb D, Spitz LM, Tartakoff A, Ohno M (1993) Regulation of RNA processing and transport by
a nuclear guanine nucleotide release protein and members of the Ras superfamily. EMBO J 12, 2929-2937.
Kadowaki T, Chen S, Hitomi M, Jacobs E, Kumagai C, Liang S, Schneiter R, Singleton D, Wisniewska J, Tartakoff AM (1994) Isolation and characterization of S. cerevisiae mRNA transport-defective (mtr) mutants. J Cell Biol 126, 649-659.
Liang S, Hitomi M, Tartakoff A (1995) Adenoviral E1B-55kDa protein inhibits yeast mRNA export. Proc Natl Acad Sci 92, 7372-7375.
Singh N, Liang L-N, Tykocinski M, Tartakoff A (1996) A novel class of cell surface glycolipids of mammalian cells. J Biol Chem 271, 12879-12884.
Liang S, Hitomi M, Hu Y-H, Liu Y, Tartakoff A (1996) A DEAD-box family protein is required for nucleocytoplasmic transport of yeast mRNA. Mol Cell Biol 16, 5139-5146.
Liu Y, Liang S, Tartakoff A (1996) Heat shock disassembles the nucleolus. EMBO J 15, 6750-6757.
Tseng S, Weaver P, Liu Y, Hitomi M, Tartakoff A, Chang T-H (1998) A cytosolic RNA helicase required for poly(A)+ RNA export. EMBO J 17, 2651-2662.
Liu Y, Guo W, Tartakoff P, Tartakoff A (1999) A Crm1p-independent path for export of the mRNA-binding protein, Mtr13p/Npl3p. Proc Natl Acad Sci USA 96, 6739-6744.
Nanduri J, Mitra S, Andrei C, Liu Y, Yu Y, Hitomi M, Tartakoff A (1999) Unexpected link between the secretory path and the nucleus. J Biol Chem 274, 33785-33789.
Tao T, Tartakoff A (2001) Nuclear relocation of normal Huntington. Traffic 2, 385-394.
Lichtenstein M, Guo W, Tartakoff A (2001) Control of nuclear export of hn RNPA1. Traffic 2, 261-267.
Nanduri J, Tartakoff A (2001) Perturbation of the nucleus: a novel Hoglp-independent, Pkclp- dependent consequence of hypertonic shock. Mol Cell Biol 12, 1835-1841.
Nanduri J, Tartakoff A (2001) The arrest of secretion response. Mol Cell 8, 281-289.
Morel-Huaux VM, Pypaert M, Wouters S, Tartakoff AM, Jurgen U, Gevaert K, Courtoy P (2002) The calcium- binding protein p54/NEFA is a novel luminal resident of medial Golgi cisternae that traffics independently of mannosidase II. Eur J Cell Biol 81, 87-100.
Tartakoff AM (2002) George Emil Palade, Charismatic Virtuoso. Nature Rev Mol Cell Biol 3, 871-876.
Tartakoff AM, Matera AG, Pimplikar S, Weimbs T (2004) Regulation of nuclear functions - Nucleocytoplasmic transport in context. Eur J Cell Biol 83, 185-192.
Gabel L, Won S, Kawai H, McKinney M, Tartakoff A, Fallon J (2004) Visual experience regulates transient expression and dendritic localization of Fragile X mental retardation protein. J Neurosci 24, 10579-10583.
Heemskerk et al. Drug screening of multiple disease models to test relatedness of neurodegeneration mechanisms. Submitted.