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Raymond W. Redline, M.D.ProfessorMailing Address: email: Raymond.Redline@Case.edu |
Biography
| 1975 | AB, Biochemistry, Magna cum Laude, Brown University, Providence, RI |
| 1979 | MD, Boston University School of Medicine, Boston, MA |
| 1979-1980 | Resident, Obstetrics and Gynecology, Case Western Reserve University, Cleveland, OH |
| 1980-1984 | Resident, Anatomic and Clinical Pathology, Case Western Reserve University, Cleveland, OH |
| 1983-1984 | Chief Resident in Pathology, Case Western Reserve University, Cleveland, OH |
| 1984 | Diplomate, American Board of Pathology, Anatomic and Clinical Pathology |
| 1984-1985 | Fellow, Gynecologic and Perinatal Pathology, Brigham and Women's Hospital, Boston, MA (Shirley Driscoll, MD) |
| 1985-1988 | Postdoctoral Fellow, Committee for Immunology, Harvard Medical School, Boston, MA (Christopher Lu, MD) |
| 1985-1989 | Instructor in Pathology, Harvard Medical School, Boston, MA |
| 1989-1990 | Assistant Professor of Pathology, Harvard Medical School, Boston, MA |
| 1989-1992 | Clinical Investigator Award, National Institute of Child Health and Human Development, National Institute of Heath |
| 1990 | American Board of Pathology, Special Qualification in Pediatric Pathology |
| 1990-1995 | Assistant Professor of Pathology, Case Western Reserve University, Cleveland, OH |
| 1991-present | Secondary Appointment, Department of Reproductive Biology, Case Western Reserve University, Cleveland, OH |
| 1995-2001 | Associate Professor of Pathology, Case Western Reserve University, Cleveland, OH |
| 2001 | Professor of Pathology, Case Western Reserve University, Cleveland, OH |
Research
Mechanisms that facilitate and protect the developing fetus within the uterus are obscure. Hence,
the pathogenesis of several important pregnancy disorders is poorly understood and we have little insight
into the underlying etiology of many adverse pregnancy outcomes. The focus of my work has been to
understand basic developmental mechanisms in murine and human placentas and how they are altered in
various disease states. Our most recent efforts have centered on standardization of diagnostic criteria
and terminology in perinatal pathology and determination of which lesions are most strongly associated
with specific adverse outcomes.
Publications
Khong TY, Bendon RW, Qureshi F, Redline RW, Gould S, Stallmach T, Lipsett J, Staples A (2000)
Chronic deciduitis in the placental basal plate: definition and inter-observer reliability. Hum Pathol
31, 292-295.
Fulton SA, Martin TD, Redline RW, Boom WH (2000) Compartmentalization of primary immune responses to M. bovis-BCG infection in C57Bl/6 mice. Am J Resp Molec Biol 22, 333-343.
Redline RW, Wilson-Costello D, Borawski E, Fanaroff AA, Hack MB (2000) The relationship between placental and clinical factors in very low birthweight children with neurologic impairment. Pediatr Res 47, 1-6.
Zaragoza MV, Surti U, Redline RW, Millie E, Chakravarti A, Hassold TJ (2000) Origin and phenotype of triploidy in spontaneous abortions: predominance of diandry and its association with partial hydatidiform mole. Am J Hum Genet 66, 1807-1820.
Ogino S, Redline RW (2000) Villous capillary lesions of the placenta: Distinctions between chorangioma, chorangiomatosis, and chorangiosis. Hum Pathol 31, 945-954.
Milstone DS, Redline RW, O'Donnell PE, Davis VM, Stavrakis G (2000) E-selectin expression and function at the fetal-maternal interface in placenta: Regulation by a unique, trophoblast-restricted transcriptional mechanism conserved between humans and mice. Devel Dynam 219, 63-76.
Wilson KA, Martin TD, Reba SM, Aung H, Redline RW, Boom WH, Toossi Z, Fulton SA (2000) Latency associated peptide of transforming growth factor-beta (LAP) enhances mycobacterocidal immunity in lung during M. Bovis-BCG infection in C57BL/6 mice. Infect Immun 68, 6505-6508.
Boyd TK, Redline RW (2000) Chronic histiocytic intervillositis: A placental lesion associated with recurrent reproductive loss. Hum Pathol 31, 1389-1396.
Redline RW, O'Riordan MA (2000) Placental lesions associated with cerebral palsy and neurologic impairment following term birth. Arch Pathol Lab Med 124, 1785-1791.
Redline RW, Shah D, Saker H, Schluchter M, Salvator A (2001) Placental lesions associated with abnormal growth in twins. Pediatr Devel Pathol 4, 473-481.
Gottwein JM, Blanchard TG, Targoni OS, Zagorski BM, Redline RW, Nedrud JG, Tary-Lehmann M, Lehmann PV, Czinn SJ (2001) Protective anti-Helicobacter immunity is induced with alum or complete Freund’s adjuvant by systemic immunization. J Infect Dis 184, 308-314.
Redline RW (2001) Macrophages in the basal plate of pre-eclamptic placentas. Placenta 22, 891-892.
Dahms B, Boyd T, Redline RW (2002) Severe perinatal liver disease associated with fetal thrombotic vasculopathy in placenta. Pediatr Devel Pathol 5, 80-85.
Garhart CA, Redline RW, Nedrud JG, Czinn SJ (2002) Clearance of Helicobacter pylori infection and resolution of postimmunization gastritis in a kinetic study of prophylactically immunized mice. Infect Immun 70, 3529-3538.
Redline RW, Wilson-Costello D, Hack M (2002) Placental and other perinatal risk factors for chronic lung disease in very low birth weight infants. Pediatr Res, in press.
Scher MS, Redline RW, Bangert B (2002) Delayed onset of status epilepticus after transient asphyxia in an asymptomatic fullterm neonate. J Child Neurol, in press.
Grether JK, Nelson KB, Walsh E, Willoughby RE, Redline RW (2002) Intrauterine exposure to infection and risk of cerebral palsy in very preterm infants. Arch Pediatr Adolesc Med, in press.
Invited Reviews:
Redline RW (2000) Invited Commentary: Role of uterine natural killer cells and gamma-interferon in
placental development. J Exp Med 192, F1-F4.
Redline RW (2002) Invited Commentary: Context - Clinically and biologically relevant patterns of placental inflammation. Pediatr Devel Pathol 5, 326-328.
Redline RW (2002) Invited Commentary - Subacute chorioamnionitis with amniotic necrosis: a placental reaction pattern associated with neonatal chronic lung disease. Adv Anat Pathol, in press.
Redline RW (2002) Invited Commentary - Maternal floor infarction and massive perivillous fibrin deposition: clinicopathologic entities in flux. Adv Anat Pathol, in press.
Books:
Kraus FT, Redline RW, Gersell D (2002) Non-Tumor Diagnostic Surgical Pathology: Placenta. Armed
Forces Institute of Pathology, Washington DC (in press)