Raymond W. Redline, M.D.

Professor

Mailing Address:
11100 Euclid Ave.
Cleveland, OH 44106

phone: (216) 844-1813
email: Raymond.Redline@Case.edu

Biography

1975 AB, Biochemistry, Magna cum Laude, Brown University, Providence, RI
1979 MD, Boston University School of Medicine, Boston, MA
1979-1980 Resident, Obstetrics and Gynecology, Case Western Reserve University, Cleveland, OH
1980-1984 Resident, Anatomic and Clinical Pathology, Case Western Reserve University, Cleveland, OH
1983-1984 Chief Resident in Pathology, Case Western Reserve University, Cleveland, OH
1984 Diplomate, American Board of Pathology, Anatomic and Clinical Pathology
1984-1985 Fellow, Gynecologic and Perinatal Pathology, Brigham and Women's Hospital, Boston, MA (Shirley Driscoll, MD)
1985-1988 Postdoctoral Fellow, Committee for Immunology, Harvard Medical School, Boston, MA (Christopher Lu, MD)
1985-1989 Instructor in Pathology, Harvard Medical School, Boston, MA
1989-1990 Assistant Professor of Pathology, Harvard Medical School, Boston, MA
1989-1992 Clinical Investigator Award, National Institute of Child Health and Human Development, National Institute of Heath
1990 American Board of Pathology, Special Qualification in Pediatric Pathology
1990-1995 Assistant Professor of Pathology, Case Western Reserve University, Cleveland, OH
1991-present Secondary Appointment, Department of Reproductive Biology, Case Western Reserve University, Cleveland, OH
1995-2001 Associate Professor of Pathology, Case Western Reserve University, Cleveland, OH
2001 Professor of Pathology, Case Western Reserve University, Cleveland, OH
2005 Professor, Reproductive Biology, Case Western Reserve University, School of Medicine, Cleveland, OH
2010-present Institutional Pathologist, Multidisciplinary Vascular Anomalies Center, Rainbow Babies and Children's Hospital
2011-present Section Head, Pediatric Pathology and Institutional Pathologist, Children's Oncology Group, Case Comprehensive Cancer Center
2011-present Section Head, Gynecologic Pathology and Institutional Pathologist, Gynecologic Oncology Group, Case Comprehensive Cancer Center


Research
Mechanisms that facilitate and protect the developing fetus within the uterus are obscure. Hence, the pathogenesis of several important pregnancy disorders is poorly understood and we have little insight into the underlying etiology of many adverse pregnancy outcomes. The focus of my work has been to understand basic developmental mechanisms in murine and human placentas and how they are altered in various disease states. Our most recent efforts have centered on standardization of diagnostic criteria and terminology in perinatal pathology and determination of which lesions are most strongly associated with specific adverse outcomes.

Publications
Redline RW, Faye-Peterson O, Heller D, Qureshi F, Savell V, Vogler C, Amniotic fluid infection: Nosology and reproducibility of placental reaction patterns. Pediatr Devel Pathol 2003; 6: 435-448.

Han YH, Redline RW, Li M, Yin L, Hill G, McCormick TS. Fusobacterium nucleatum induces premature and term stillbirth in pregnant mice: implication of oral bacteria in preterm birth. Infect Immun 2004; 72: 2272-2279.

Redline RW, Boyd T, Campbell V, Hyde S, Kaplan C, Khong TY, Prashner H, Waters BL. Maternal vascular underperfusion: Nosology and reproducibility of placental reaction patterns Pediatr Devel Pathol 2004; 7:237-249.

Redline RW, Ariel I, Baergen RN, deSa DJ, Kraus FT, Roberts DJ, Sander CM. Fetal vascular obstructive lesions: Nosology and reproducibility of placental reaction patterns. Pediatr Devel Pathol 2004; 7: 443-452.

Redline RW. Severe fetal placental vascular lesions in term infants with neurologic impairment. Am J Obstet Gynecol 2005; 192: 452-457.

Redline RW, Progress in pathology: villitis of unknown etiology: noninfectious chronic villitis, Hum Pathol 2007; 38: 1439-1446.

Redline RW, Minich N, Taylor HG, Hack M, Placental vascular and inflammatory lesions as predictors of cerebral palsy and abnormal neurocognitive function at school age in extremely low birth weight infants (<1 Kg) Pediatr Devel Pathol, 2007; 10:282-292.

Redline RW, Placental pathology: a systematic approach with clinical correlations. Placenta 29, Supplement A, Trophoblast Research 2008; 22:S86-S91.

Redline RW, Cerebral palsy in term infants: a clinicopathologic analysis of 158 medicolegal case reviews. Pediatr Devel Pathol 2008; 11: 456-464.

Redline RW, Sagar P, King ME, Grabowski EF, Krishnamoorthy K, Roberts D. Case Records of the Massachusetts General Hospital (12-2008): A newborn with intermittent apnea and seizures, N Engl J Med 2008; 358: 51-61.

Redline RW , Disorders of Placental Circulation and The Fetal Brain. In Fetal Neurology (A J du Plessis, ed) Clin Perinatol. 2009 Sep;36(3):549-59.

Redline RW, Han YW, Lu CY, Murine Fetoplacental Infection Models. Infect Immun 2010; 78: 4965-4966

Bagby C, Redline RW, Multifocal chorangiomatosis. Pediatr Dev Pathol 2011; 14(1): 38-44.

Redline RW, The placental inflammatory response in chorioamnionitis, Seminars in Fetal and Neonatal Medicine, 2012; 17:20-25.

Redline RW, Distal villous immaturity/ placental maturation defect, Diagnostic Histopathology 2012; 18(5):189-94

Books:
Kraus FT, Redline RW, Gersell D, Nelson DM, Dicke JM. Placental Pathology, Armed Forces Institute of Pathology Non-tumor Diagnostic Pathology Series, American Registry of Pathology, Washington DC, 2004