Miguel E. Quiñones-Mateu, Ph.D.
Assistant Professor
Scientific Director, UHTL

Mailing Address:
7100 Euclid Avenue, Suite 190
Cleveland, OH 44103

phone: (216) 286-4283
fax: (216) 201-5432
email: Miguel.Quinones@case.edu

Biography

Dr. Quiñones-Mateu's successful career encompasses over 20 years of productive research in HIV/AIDS in three different countries. He holds a bachelor's degree in Biology from the Universidad Central de Venezuela and completed his Ph.D. in Molecular Biology at the Centro de Biologia Molecular "Severo Ochoa", Universidad Autonoma de Madrid, Spain. He continued his training as a Postdoctoral Fellow in the Department of Medicine at Case Western Reserve University, prior to becoming Assistant Professor in the Department of Virology, The Cleveland Clinic. Recently, and following a five-year hiatus in the corporate world (Diagnostic Hybrids, A Quidel Company), Dr. Quinones-Mateu returned to the academia as Assistant Professor of Pathology at CWRU and Scientific Director of the University Hospital Translational Laboratory (www.uhtl.org).

Research

Despite the success of current antiretroviral therapy, it is difficult to durably control HIV replication in part because of the extraordinary capacity of the virus to develop resistance to antiretroviral drugs. This extreme genetic variability is one of the main obstacles for HIV disease prevention, treatment and overall control of the HIV epidemic. Our research focuses on understanding the mechanisms and clinical consequences of drug resistant viruses, including transmission and pathogenicity studies using state-of-the-art next generation sequencing technology.

Selected Publications

Archer, J., Weber, J., Henry, K., Winner, D., Gibson, R., Lee, L., Paxinos, E., Arts, E.J., Robertson, D.L., Mimms, L., and Quiñones-Mateu M.E. (2012). Use of four next-generation sequencing platforms to determine HIV-1 coreceptor tropism. PLoS ONE, 7:e49602

Quiñones-Mateu M.E., and Vanham, G. (2012). HIV microbicides: where are we now? (Editorial).

Weber, J., Vazquez, A.C, Winner, D. Rose, J.D., Wylie, D., Rhea, A., Henry, K., Pappas, J., Wright, A., Mohamed, N., Gibson, R., Rodriguez, B., Soriano, V., King, K., Arts, E.J., Olivo, P.D., and Quiñones-Mateu M.E. (2011). Novel method for simultaneous quantification of phenotypic resistance to maturation, protease, reverse transcriptase, and integrase inhibitors based on 3'Gag(p2/p7/p1/p6)/PR/RT/INT-recombinant viruses: a useful tool in the multi-target era of antiretroviral therapy. Antimicrobial Agents and Chemotherapy, 55:3729-3742

Selhorst P., Vazquez A.C., Terrazas-Aranda, K., Michiels, J., Vereecken, K., Heyndrickx, L., Weber, J., Quiñones-Mateu M.E., Arien, K.K., and Vanham, G. (2011). Human immunodeficiency virus type 1 (cross-) resistance to non-nucleoside reverse transcriptase inhibitors currently under development as microbicides. Antimicrobial Agents and Chemotherapy, 55:1403-1413

Jegede O., Khodyakova A., Chernov M., Weber, J., Menendez-Arias, L., Gudkov A., and Quiñones-Mateu M.E. (2011). Identification of low-molecular weight inhibitors of HIV-1 reverse transcriptase using a cell-based high-throughput screening system. Antiviral Research, 91:94-98

Covens K., Dekeersmaeker N., Schrooten Y., Weber J., Schols D., Quiñones-Mateu M.E., Vandamme A-M., and Van Laethem K.V. (2009). A novel recombinant virus assay for measuring susceptibility to clinically approved drugs in HIV-1 group M subtypes. Journal of Clinical Microbiology, 47:2232-2242

Weber J., Weberova J., Carobene M., Mirza M., Martinez-Picado J., Kazanjian P., and Quiñones-Mateu M.E. (2006). Use of a novel assay based on intact recombinant viruses expressing green (EGFP) or red (DsRed2) fluorescent proteins to examine the contribution of pol and env genes to overall HIV-1 replicative fitness. Journal of Virological Methods, 136:102-117

Rangel H.R., Weber J., Chakraborty B., Gutierrez A., Marotta M.L., Mirza M., Kiser P., Martinez M.A., Este J.A., & Quiñones-Mateu M.E. (2003). Role of the human immunodeficiency virus type 1 envelope gene in viral fitness. Journal of Virology, 77:9069-9073

Weber J., Rangel H.R., Chakraborty B., Tadele M., Martinez M.A., Martinez-Picado J., Marotta M.L., Mirza M., Ruiz L., Clotet B., Wrin T., Petropoulos C.J., & Quiñones-Mateu M.E. (2003). A novel TaqMan real time-PCR method to estimate ex vivo human immunodeficiency virus type 1 fitness in the era of multi-target (pol and env) antiretroviral therapy. Journal of General Virology, 84:2217-2228

Weber J., Rangel H.R., Chakraborty B, Marotta M.L., Valdez H., Fransen K., Florence E., Connick E., Smith K.Y.,. Colebunders R.L, Landay A., Kuritzkes D., Lederman M. M., Vanham G. & Quiñones-Mateu M.E. (2003). Role of baseline pol genotype in human immunodeficiency virus type 1 fitness evolution. Journal of AIDS, 33:448-460

Quiñones-Mateu M.E., Lederman M.M., Feng Z., Chakraborty B., Weber J., Rangel H.R., Marotta M.L., Mirza M., Jiang B., Kiser P., Medvik K., Sieg S.F., and Weinberg A. (2003). Human epithelial -defensins 2 and 3 inhibit HIV-1 replication. AIDS, 17:F39-F48

Quiñones-Mateu M.E., Tadele M., Parera M., Mas A., Weber J., Rangel H.R., Chakraborty B., Clotet B., Domingo E., Menendez-Arias L., & Martinez M.A. (2002). Insertions in the reverse transcriptase increase both drug resistance and viral fitness in a human immunodeficiency virus type 1 isolate harboring the multi-nucleoside reverse transcriptase inhibitor resistance 69 insertion complex mutation. Journal of Virology, 76:10546-10552

Quiñones-Mateu M.E., Gao Y., Ball S.C., Marozsan A., Abraha A., & Arts E.J. (2002). In vitro intersubtype recombinants of human immunodeficiency virus type 1: comparison to recent and circulating in vivo recombinant forms. Journal of Virology, 76:9600-9613

Quiñones-Mateu M.E., Ball S.C., Marozsan A. J., Torre V. S., Albright J.L., Vanham G., van der Groen G., Colebunders R.L. & Arts E.J. (2000). A dual infection/competition assay shows a correlation between ex vivo HIV-1 fitness and disease progression. Journal of Virology, 74:9222-9233

Quiñones-Mateu M.E., Dopazo J., Esté J.A., Rota T.R., & Domingo E. (1995). Molecular characterization of human immunodeficiency virus type 1 isolates from Venezuela. AIDS Research and Human Retroviruses, 11:605-616

Nájera, I., Holguín A., Quiñones-Mateu M.E., Muñoz-Fernández M.A., Nájera R., López-Galíndez C., & Domingo E. (1995). The pol gene quasispecies of human immunodeficiency virus. Mutations associated with drug resistance in virus from patients undergoing no drug therapy. Journal of Virology, 69:23-31