Gregory MacLennan, M.D.

Professor

Mailing Address:
11100 Euclid Ave.
Cleveland, OH 44106

phone: (216) 844-7452
email: Gregory.MacLennan@UHhospitals.org

Biography
Dr. Gregory MacLennan earned his M.D. degree from the University of Manitoba, Canada, in 1971. He spent six years training in General Surgery and Urology at Manitoba Affiliated Teaching Hospitals, and followed this with a fellowship in Urodynamics at St. Peter's Hospitals, London, England. From 1978 until 1989, Dr. MacLennan practiced Urology in Grand Forks, N.D. and progressed from Clinical Instructor to Associate Professor of Surgery at the University of North Dakota School of Medicine. In 1989, he returned to Manitoba Affiliated Teaching Hospitals and spent 5 years in Residency and fellowship training in Anatomic Pathology and Cytopathology. In 1994 he began a Fellowship in Surgical and Genitourinary Pathology at Mayo Clinic, Rochester, MN. Following his Fellowship, he joined the staff of the Department of Pathology at CWRU in 1995. Dr. MacLennan is Board certified in both Urology and Anatomic Pathology in both Canada and the United States. Additionally, he is Board certified in Cytopathology. Dr. MacLennan is Professor of Pathology at Case Western Reserve School of Medicine, with secondary appointments in Urology and Oncology. He is the Division Chief of Anatomic Pathology, the Director of the Human Tissue Procurement Facility at University Hospitals of Cleveland, and Director of the Tissue Procurement and Histology Core Facility of the Seidman Cancer Center.

Research
Dr. MacLennan has a particular interest in genitourinary pathology. Much of his time is committed to diagnostic surgical pathology and cytopathology. His research has been predominantly clinically oriented, in collaboration with urologists, oncologists and other pathologists, but has also involved collaborations with basic scientists.

Recent Publications: Peer-Reviewed Articles
Loberant N, Bhatt S, MacLennan GT, Dogra VS. Striated appearance of the testis. Ultrasound Q. 26: 37-44, 2010.

Joshi N, Bissada NF, Bodner D, MacLennan GT, Narendran S, Jurevic R, Skillicorn R. Association between periodontal disease and prostate specific antigen levels in chronic prostatitis patients. J Periodontology 81: 864-869, 2010.

Wang H, Kang W, Zhu H, MacLennan GT, Rollins AM. Three-dimensional imaging of ureter with endoscopic optical coherence tomography. Urology. 2011 Jan 20. [Epub ahead of print].

Phitayakorn R, MacLennan GT, Sadow P, Wilhelm S. Adrenal adenomatoid tumor in a patient with human immunodeficiency virus. Rare Tumors 2011;3:e21

Zechel JL, MacLennan GT, Heaney JD, Nadeau JH. Spontaneous metastasis in mouse models of testicular germ-cell tumors. Int J Androl. 2011 Jun 9. doi: 10.1111/j.1365-2605.2011.01160.x. [Epub ahead of print]

Vykhovanets EV, MacLennan GT, Vykhovanets OV, Gupta S. IL-17 expression by macrophages is associated with proliferative inflammatory atrophy lesions in prostate cancer patients. Int J Clin Exp Pathol 2011 Aug 15;4(6):552-65.

Vykhovanets EV, MacLennan GT, Vykhovanets OV, Cherullo EE, Ponsky LE, Gupta S. Molecular Imaging of Nuclear Factor-κB in Bladder as a Primary Regulator of Inflammatory Response. J Urol. 2011 Nov 16. [Epub ahead of print] PubMed PMID: 22099998.

Shankar E, Vykhovanets EV, Vykhovanets OV, MacLennan GT, Singh R, Bhaskaran N, Shukla S, Gupta S. High-fat diet activates pro-inflammatory response in the prostate through association of Stat-3 and NF-κB. Prostate. 2011 May 20. doi: 10.1002/pros.21425. [Epub ahead of print] PubMed PMID: 21604287; PubMed Central PMCID: PMC3161175.

Shukla S, MacLennan GT, Fu P, Gupta S. Apigenin attenuates insulin-like growth factor-I signaling in an autochthonous mouse prostate cancer model. Pharm Res (in press).

Maurice MJ, Vricella GJ, MacLennan GT, Buehner P, Ponsky LE. Endoscopic snare resection of bladder tumors: evaluation of an alternative technique for bladder tumor resection. J Endourol. 2012 Jun;26(6):614-7. Epub 2012 May 3.

Salem S, Ponsky L, Abouassaly R, Cherullo E, Isariyawongse J, MacLennan GT, Nakamoto D, Haaga, John. Image-Guided Biopsy of Small Renal Masses in the Era of Ablative Therapies. Int J Urol (in press).

Cheng L, MacLennan GT, Lopez-Beltran A. Histologic Grading of Urothelial Carcinoma: A Reappraisal. Hum Pathol (in press).

MacLennan GT, Cheng L. Precursors of selected cancers of the genitourinary tract. AUA Update Series 2012; Volume 31, Lesson 19, pp 000-000. (in press)

Cheng L, MacLennan GT, Lopez-Beltran A, Montironi R. Anatomic, morphologic and genetic heterogeneity of prostate cancer: implications for clinical practice. Expert Rev Anticancer Ther 12(11) 00-00 (2012) (in press).

Recent Publications: Book Chapters
MacLennan GT and Cheng L. Neoplasms of the Kidney. In: Bostwick DG and Cheng L, eds. Urologic Surgical Pathology, 2nd Edition. Edinburgh: Mosby Elsevier. 2008.

Cheng L, Lopez-Beltran A, MacLennan GT, Montironi R, Bostwick DG. Neoplasms of the Urinary Bladder. In: Bostwick DG and Cheng L, eds. Urologic Surgical Pathology, 2nd Edition. Edinburgh: Mosby Elsevier. 2008.

Cheng L, Zhang S, Kuhar M, Wang M, Zhang DY, MacLennan GT. Laser Capture Microdissection. In: Cheng L, Zhang DY, eds. Molecular Genetic Pathology (2nd edition). New York: Springer (in press).

Zhang S, Davidson DD, Montironi R, Lopez-Beltran A, MacLennan GT, Cheng L. Conceptual evolution in cancer biology. In: Cheng L, Zhang DY, eds. Molecular Genetic Pathology (2nd edition). New York: Springer (in press).

Williamson SR, Lopez-Beltran A, Zhang S, MacLennan GT, Montironi R, Cheng L: Chapter 6: Immunological & Molecular Studies in Kidney Tumors. In Albitar MX (ed): Immunological & Molecular Diagnosis of Cancer. Page 177-192. Nova Science Publishers, Hauppauge, NY, 2011.

MacLennan GT, Cheng L. Tumors of the kidney. In: Cheng L and Bostwick DG, eds. Essentials of Anatomic Pathology (3rd edition). New York: Humana Press/Springer. 2011: 1487-1514.

MacLennan GT, Larchian WA, Cheng L, Bodner DR, Hardin BM, Goldman HB, Cherullo EE, Ponsky LE. Correlative pathologic features of endoscopically identified lesions of bladder, urachus and urethra. In: Hansel DE, McKenney J, Stephenson AJ, Chang S, eds. The Urinary Tract: A Comprehensive Guide to Patient Diagnosis and Management. Springer-Verlag (in press).

Cheng L, MacLennan GT, Lopez-Beltran A: Histologic grading of urothelial carcinoma. In Damjanov I, Fan F (eds) Cancer Grading Manual (2nd edition). New York, NY: Springer, 2013 (in press).

Recent Publications: Books
MacLennan GT, Cheng L. Atlas of Genitourinary Pathology. Springer-Verlag London Limited 2011.

MacLennan GT. Hinman's Atlas of UroSurgical Anatomy, 2nd edition. Elsevier, Philadelphia. 2012.

Dogra VS and MacLennan GT (Eds). Genitourinary Radiology: The Pathologic Basis. Volume I: Kidney, Bladder and Urethra. Springer, London. 2012 (in press).