Feng Lin, Ph.D.Associate Professor
11100 Euclid Ave
Cleveland, OH 44106
phone: (216) 368-2118
Dr. Feng Lin received his B.S. from NanKai University, China (1992). He completed his Ph.D. at Sichuan University, China, in 1997. That year he came to Case as a Research Associate in the Institute of Pathology. He is presently holding an Associate Professor position.
The Complement system plays important roles in fighting pathogen invasions, and helps to maintain body homeostasis. Complement activation products promote inflammation, and help to eliminate invaded pathogen through different mechanisms. They are also important for many immunological reactions including immune complex clearance, antibody production and T cell activation. Insufficient or excess complement activation contribute to various disease states including transplant rejection, cancer, systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, myasthenia gravis and age related macular degeneration. Using gene knockout mice and transgenic mice as disease models, my lab is interested in studying complement activation and regulation in disease states, thus eventually developing novel reagents to fight against those diseases.
Fengqi An, Qing Li, Zhidan Tu, Hong Bu, Chi-Chao Chan, Rachel R Caspi and Feng Lin (2009) DAF protects against T cell autoreactivity that leads to experimental autoimmune uveitis. Invest Ophthalmol Vis Sci. 50 (8): 3778-82
Qing Li, Kristine Nacion, Hong Bu and Feng Lin (2009). The complement inhibitor FUT-175 suppresses T cell autoreactivity in experimental autoimmune encephalomyelitis. Am. J. Pathol. 175 (2): 661-7
Zhidan Tu, Mark Cohen, Hong Bu and Feng Lin (2009). Tissue distribution and function assays of Sushi domain containing protein 4. Am. J. Pathol. 176(5): 2378-84.
Zhidan Tu, Qing Li, Hong Bu and Feng Lin (2010). Mesenchymal stem cells inhibit complement activation by secreting factor H. Stem Cells Dev. 19(11):1803-9
Zhidan Tu, Hong Bu, James E Dennis and Feng Lin (2010) Efficient osteoclast differentiation requires local complement activation. Blood 116(22):4456-63
Zhidan Tu, Qing Li, Hong-Shiue Chou, Ching-Chuang Hsieh, Howard Meyerson, Marion G. Peters, Hong Bu, John J Fung, Shiguang Qian, Lina Lu and Feng Lin (2011) Complement mediated hepatocyte injury in a model of autoantibody induced hepatitis. Immunobiology 216(4):528-34