Pathology

Hyoung-gon Lee, Ph.D.

Instructor

Mailing Address:
2103 Cornell Rd.
WRB 5123
Cleveland, OH 44106-7288

phone: (216) 368-6887
fax: (216) 368-0494
email: Hyoung-gon.Lee@Case.edu

Biography
Ph.D., Case Western Reserve University

Research
Aberrant cell cycle activation in neurons is now emerging as a key pathogenic mechanism of neurodgeneration in many neurodegenerative diseases such as Alzheimer disease. These findings led us to develop a novel hypothesis that neurodegeneration in Alzheimer disease, like cancer, is a disease of inappropriate cell cycle control. However, its exact role in disease pathogenesis is unclear primarily because of the absence of research models to study cell cycle re-entry in adult neurons in vivo. To pursue this, we have developed the transgenic mice models and current projects are focused on delineating the pathogenic mechanism of cell cycle re-entry and its causal relationship with the pathogenesis of Alzheimer disease in these models.

Publications
Ogawa O, Zhu X, Lee HG, Bowser R, Ghanbari HA, Obrenovich ME, Castellani RJ, Smith MA, Ectopic expression of phosphorylated histone H3 in Alzheimer disease: a mitotic catastrophe?, Acta Neuropathologica, 105(5): 524-8, 2003

Ogawa O, Lee HG, Zhu X, Raina A, Harris PL, Castellani RJ, Perry G, Smith MA, Increased p27, an essential component of cell cycle control, in Alzheimer’s disease, Aging Cell, 2, 105-110, 2003

Zhu X, Sun Z, Lee HG, Perry G, Smith MA, Distribution, levels and activation of MEK1 in Alzheimer disease, Journal of Neurochemistry, 86, 136-42, 2003

Lee HG, Ogawa O, Zhu X, O’Neill MJ, Petersen RB, Castellani RJ, Ghanbari H, Perry G, Smith MA, Aberrant Expression of Metabotropic Glutamate Receptor 2 (mGluR2) in the Vulnerable Neurons of Alzheimer Disease, Acta Neuropathologica, 107, 365-371, 2004

Zhu X, Wang Y, Ogawa O, Lee HG, Raina AK, Siedlak SL, Harris PL, Fujioka H, Shimohama S, Tabaton M, Atwood CS, Petersen RB, Perry G, Smith MA, Neuroprotective properties of Bcl-w in Alzheimer disease, Journal of Neurochemistry, 89, 1233-1240, 2004

Lee HG, Perry G, Moreira PI, Garrett MR, Liu Q, Zhu X, Takeda A, Nunomura A, Smith MA, Tau phosphorylation in Alzheimer’s disease: pathogen or protector?, Trends in Molecular Medicine, 11, 164-169, 2005

Smith MA, Zhu X, Lee HG, Harris PLR, Fortino AE, Perry G, Castellani RJ, Sequestration of p27 within the cytoplasm of cardiac myocytes in chronic ischemic heart disease: pathogenic implications for ischemic cardiomyopathy, AGE, 28, 85-91, 2006

Lee HG, Ueda M, Zhu X, Perry G, Smith MA, Ectopic expression of phopho-Smad2 in Alzheimer disease: uncoupling of the TGF-β pathway, Journal of Neuroscience Research, 84, 1856-1861, 2006

Lee HG, Ueda M, Miyamoto Y, Yoneda Y, Zhu X, Perry G, Smith MA, Aberrant localization of importin α in hippocampal neurons in Alzheimer disease, Brain Research, 1124, 1-4, 2006

Lee HG, Zhu X, Castellani RJ, Nunomura A, Perry G, Smith MA, Amyloid-beta in Alzheimer disease: The null versus the alternate hypothesis, Journal of Pharmacology and Experimental Therapeutics, 321, 823-829, 2007

Gustaw KA, Garrett MR, Lee HG, Castellani RJ, Zagorski MG, Praasam A, Siedlak SL, Zhu X, Perry G, Friedland RP, Smith MA, Antigen-antibody dissociation in Alzheimer disease: a novel approach to diagnosis, Journal of Neurochemistry, 106, 1350-1356, 2008

Myung NH, Zhu X, Kruman II, Castellani RJ, Petersen RB, Siedlak SL, Perry G, Smith MA, Lee HG, Evidence of DNA damage in Alzheimer disease: phosphorylation of histone H2AX in astrocytes, AGE 30, 209-215, 2008

Lee HG, Zhu X, Casadesus G, Pallas M, Camins A, O’Neill MJ, Nakanishi S, Perry G, Smith MA, The effect of mGluR2 activation on signal transduction pathways and neuronal cell survival, Brain Research 1249, 244- 250, 2009

Lee HG, Casadesus G, Zhu X, Castellani RJ, McShea A, Perry G, Petersen RB, Bajic V, Smith MA, Cell cycle re-entry mediated neurodegeneration and its role in the pathogenesis of Alzheimer’s disease, Neurochemistry International 54, 84-88, 2009

Lee HG, Casadesus G, Nunomura A, Zhu X, Castellani RJ, Richardson SL, Perry G, Felsher DW, Petersen RB, Smith MA, The neuronal expression of MYC causes a neurodegenerative phenotype in a novel transgenic mouse, American Journal of Pathology 174, 891-897, 2009

Lee HP, Zhu X, Zhu X, Perry G, Sayre LM, Smith MA, Lee HG, The essential role of ERK in 4-oxo-2- nonenal mediated cytotoxicity in SH-SY5Y human neuroblastoma cells, Journal of Neurochemistry 108, 1434- 1441, 2009

Casley CS, Lakics V, Lee HG, Broad LM, Day TA, Cluett T, Smith MA, O’Neill MJ, Kingston AE, Up-regulation of astrocyte metabotropic glutamate receptor 5 by amyloid-beta peptide, Brain Research 1260, 65-75, 2009