Michael R. Jacobs, M.D., Ph.D

Professor

Mailing Address:
11100 Euclid Ave.
Cleveland, OH 44106

phone: (216) 844-3484
email: Michael.Jacobs@Case.edu

Biography

1971 M.B., B.Ch., Bachelor of Medicine and Surgery, University of the Witwatersrand, Johannesburg, South Africa
1972 Intern, Medicine and Surgery, Johannesburg Hospital/University of the Witwatersrand, Johannesburg, South Africa
1973-1977 Resident, School of Pathology, University of the Witwatersrand and South African Institute for Medical Research, Johannesburg, South Africa
1974 D.T.M. & H., Diploma in Tropical Medicine & Hygiene, University of the Witwatersrand, Johannesburg, South Africa
1976 D.P.H., Diploma in Public Health, University of the Witwatersrand, Johannesburg, South Africa
1977 F.F.Path.(SA), Fellowship of the Faculty of Pathology of the College of Medicine of South Africa
1977-1978 Consultant Microbiologist, Baragwanath Hospital Laboratories, South African Institute for Medical Research
1978 M.R.C.Path., Membership of the Royal College of Pathologists, England
1979 Ph. D., Doctor of Philosophy, University of the Witwatersrand, Johannesburg, South Africa
1979-present Director, Clinical Microbiology, Department of Pathology, Case Western Reserve University and University Hospitals of Cleveland
1979-1986 Assistant Professor, Department of Pathology, Case Western Reserve University
1979-1995 Assistant Professor of Medicine, Case Western Reserve University (secondary appointment)
1980 Diplomate of the American Board of Medical Microbiology
1986-1993 Associate Professor, Department of Pathology, Case Western Reserve University
1988-present Associate Director, Division of Clinical Pathology, Department of Pathology, University Hospitals of Cleveland
1993-present Professor, Department of Pathology, Case Western Reserve University
1995-present Professor of Medicine, Case Western Reserve University (secondary appointment)


Research
Antimicrobial susceptibility testing, Streptococcus pneumoniae, Haemophilus influenzae, respiratory tract infections

Publications
Dowell SF, Butler JC, Giebink GS, Jacobs MR, Jernigan D, Musher DM, Rakowski A, Schwartz B, the DRSPTWP (1999). Acute otitis media: management and surveillance in an era of pneumococcal resistance - a report from the Drug Resistant Streptococcus pneumoniae Therapeutic Working Group. Pediatr Infect Dis J 18, 1-9.

Heffelfinger JD, Dowell SF, Jorgensen JH, Klugman KP, Mabry LR, Musher DM, Plouffe JF, Rakowsky A, Schuchat A, Whitney CG and DRSP TWG Members (2000). Management of community-acquired pneumonia in the era of pneumococcal resistance: a report from the Drug-Resistant Streptococcus pneumoniae Therapeutic Working Group. Arch Intern Med 160, 1399-408.

Jacobs MR, Appelbaum PC, The Laser Group (2000). Susceptibility of 1100 Streptococcus pneumoniae strains isolated in 1997 from seven Latin American countries. Int J Antimicrobial Agents16 17-24.

Syrogiannopoulos G, Ronchetti F, Dagan R, Grivea I, Ronchetti MP, Porat N, Davies TA, Ronchetti R, Appelbaum PC, Jacobs MR (2000). Mediterranean clone of penicillin-susceptible, multidrug-resistant serotype 6B Streptococcus pneumoniae in Greece, Italy and Israel. Int J Antimicrobial Agents16, 219-224.

Nagai K, Davies TA, Pankuch GA, Dewasse BE, Jacobs MR, Appelbaum PC (2000). In vitro selection of resistance to clinafloxacin, ciprofloxacin, and trovafloxacin in Streptococcus pneumoniae. Antimicrob Agents Chemother 44, 2740-2746.

Tait-Kamradt A, Davies T, Appelbaum PC, Ddepardieu F, Courvakin P, Petipas J, Wondrack L, Walker A, Jacobs MR, Sutcliffe J (2000). Two new mechanisms of macrolide resistance in clinical strains of Streptococcus pneumoniae from Eastern Europe and North America. Antimicrob Agents Chemother 44, 3395-3401.

Joloba ML, Bajaksouzian S, Jacobs MR (2000). Evaluation of etest for susceptibility testing of Mycobacterium tuberculosis. J Clin Microbiol 38, 3834-3836.

Credito KL, Lin G, Pankuch GA, Bajaksouzian S, Jacobs MR, Applebaum PC (2000). Susceptibility of Haemophilus Influenzae and Moraxella Catarrhalis to ABT 773 compared to eleven other agents. Antimicrob Agents Chemother 45, 67-72.

Palavecino EL, Riedel I, Berrios X, Bajaksouzian S, Johnson D, Kaplan E, Jacobs MR (2001). Prevalence and mechanisms of macrolide resistance in Streptococcus pyogenes in Santiago, Chile. Antimicrob Agents Chemother 45, 339-341.

Dagan R, Hoberman A, Johnson C, Leibovitz EL, Arguedas A, Rose FV, Wynne BR, Jacobs MR (2001). Bacteriologic and clinical efficacy of high dose amoxicillin/clavulanate in children with acute otitis media. Pediatr Infect Dis J 20, 829-837.

Fendrick AM, Saint S, Brook I, Jacobs MR, Pelton S, Sethi S (2001). Diagnosis and treatment of upper respiratory tract infections in the primary care setting. Clin Ther 23, 1683-1706.

Jacobs MR, Weinberg W (2001). Evidence-based guidelines for treatment of bacterial respiratory tract infections in the era of antibiotic resistance. Manag Care Interface 14, 68-80.

Jacobs MR, Palavecino E, Yomtovian R (2001). Don't bug me: the problem of bacterial contamination of blood components-challenges and solutions. Transfusion 41, 1331-1334.

Jacobs MR (2001). Optimisation of antimicrobial therapy using pharmacokinetic and pharmacodynamic parameters. Clin Microbiol Infect 7, 589-596.

Joloba ML, Windau A, Bajaksouzian S, Appelbaum PC, Hausdorff WP, Jacobs MR (2001). Pneumococcal conjugate vaccine serotypes of Streptococcus pneumoniae isolates and the antimicrobial susceptibility of such isolates in children with otitis media. Clin Infect Dis 33, 1489-1494.

Joloba ML, Bajaksouzian S, Palavecino E, Whalen C, Jacobs MR (2001). High prevalence of carriage of antibiotic-resistant Streptococcus pneumoniae in children in Kampala Uganda. Int J Antimicrob Agents 17, 395-400.

Jones RN, Pfaller MA, Jacobs MR, Appelbaum PC, Fuchs PC (2001). Cefditoren in vitro activity and spectrum: a review of international studies using reference methods. Diagn Microbiol Infect Dis 41, 1-14.

Lee N, Song J, Kim S, Peck KR, Ahn KM, Lee SI, Yang Y, Li J, Chongthaleong A, Tiengrim S, Aswapokee N, Lin TY, Wu JL, Chiu CH, Lalitha MK, Thomas K, Cherian T, Perera J, Yee TT, Jamal F, Warsa UC, Van PH, Carlos CC, Shibl AM, Jacobs MR, Appelbaum PC (2001). Carriage of antibiotic-resistant Pneumococci among Asian children: A multinational surveillance by the Asian Network for Surveillance of Resistant Pathogens (ANSORP). Clin Infect Dis 32, 1463-1469.

Nagai K, Shibasaki Y, Hasegawa K, Davies TA, Jacobs MR, Ubukata K, Aappelbaum PC (2001). Evaluation of PCR primers to screen for Streptococcus pneumoniae isolates and ß-lactam resistance, and to detect common macrolide resistance determinants. J Antimicrobial Chemother 48, 915-918.

Palavecino EL, Riedel I, Berrios X, Bajaksouzian S, Johnson D, Kaplan E, Jacobs MR (2001). Prevalence and mechanisms of macrolide resistance in Streptococcus pyogenes in Santiago, Chile. Antimicrob Agents Chemother 45, 339-341.

Sapatnekar S, Wood EM, Miller JP, Jacobs MR, Arduino MJ, McAllister SK, Kellum ME, Roth V, Yomtovian R (2001). Methicillin-resistant Staphylococcus aureus sepsis associated with the transfusion of contaminated platelets: a case report. Transfusion 41, 1426-1430.

Share L, Chaikin S, Pomeranets S, Kiwi R, Jacobs M, Fanaroff AA (2001). Implementation of guidelines for preventing early onset group B streptococcal infection. Semin Perinatol 25, 107-113.

Clark CL, Kanagi K, Davies TA, Dewasse B, Jacobs MR, Appelbaum PC (2001). Single- and multi-step selection study of the antipneumococcal activity of BMS-284756 compared to ciprofloxacin, levofloxacin, trovafloxacin and moxifloxacin. Clin Microbiol Infect, in press.

Nagai K, Appelbaum PC, Davies TA, Kelly LM, Hoellman DB, Andrasevic AT, Drulalska L, Hryniewicz W, Jacobs, MR, Kolman J, Micileveciene J, Pana M, Setchanova L, Thege, MK, Hupkova H, Trupl J, Urbaskova P (2002). Susceptibility to telithromycin and 6 other agents, and the prevalence-detection of macrolide resistance due to L4 ribosomal protein mutation among 992 Streptococcus pneumoniae isolates from 10 Central and Eastern European countries. Antimicrob Agents Chemother 46, 371-377.

Nagai K, Appelbaum PC, Davies TA, Kelly LM, Hoellman DB, Andrasevic AT, Drulalska L, Hryniewicz W, Jacobs MR, Kolman J, Miciuleveciene J, Pana M, Setchanova L, Thege MK, Hupkova H, Trupl J, Urbaskova P (2002). Susceptibility to telithromycin in 1011 Streptococcus pyogenes isolates from 10 Central and Eastern European countries. Antimicrob Agents Chemother 46, 546-549.

Nagai K, Davies TA, Jacobs MR, Appelbaum PC (2002). Effects of amino acid alterations in penicillin- binding proteins 1a, 2b, and 2x on penicillin-binding protein (PBP) affinity of penicillin, ampicillin, amoxicillin, cefditoren, cefuroxime, cefprozil and cefaclor in 18 clinical isolates of penicillin-susceptible, -intermediate and –resistant pneumococci. Antimicrob Agents Chemother 46, 1273-1280.