Neil Greenspan, M.D., Ph.D. Professor Mailing Address: 2103 Cornell Rd. WRB 5130 Cleveland, OH 44106-7288 phone: (216) 368-1280 fax: (216) 368-0494 email: Neil.Greenspan@Case.edu

Biography
Dr. Neil Greenspan received his A.B., magna cum laude, in Biochemical Sciences from Harvard College in 1975. He then earned M.D. and Ph.D. (Immunology) degrees at the University of Pennsylvania. From 1981 until 1986, Dr. Greenspan was a Resident in Laboratory Medicine (Clinical Pathology) at Barnes Hospital, and from 1982-1985 he was a Postdoctoral Fellow in Molecular Immunology at Washington University, both in St. Louis. In 1986, Dr. Greenspan became a faculty member at the Case School of Medicine. He is currently Professor of Pathology at Case and the Director of the Histocompatibility and Immunogenetics Laboratory at University Hospitals Case Medical Center.

Research
My research interests include: understanding, at a molecular level, immunological recognition, antibody function, vaccine efficacy, mechanisms of immunity to bacterial and viral pathogens, the pathogenesis of systemic lupus erythematosus, and applications of principles of evolution to immunology and related biomedical fields.

Publications
McLay J, Leonard E, Petersen S, Shapiro D, Greenspan NS, Schreiber JR (2002). g3 gene-disrupted mice selectively deficient in the dominant IgG subclass made to bacterial polysaccharides II. Increased susceptibility to fatal pneumococcal sepsis due to absence of anti-polysaccharide IgG3 is corrected by induction of anti-polysaccharide IgG1. J Immunol 168 , 3437-3443.

Gor DO, Ding X, Li Q, Schreiber JR, Dubinsky M, Greenspan NS (2002). Enhanced immunogenicity of pneumococcal surface adhesin A by genetic fusion to cytokines and evaluation of protective immunity in mice. Infect Immun 70, 5589-5595.

Gor DO, Rose NR, Greenspan NS (2003). TH1-TH2, a Procrustean paradigm. Nature Immunol 4, 503-505.

McCool TL, Schreiber JR*, Greenspan NS* (2003). Genetic variation influences the B cell response to immunization with a pneumococcal polysaccharide conjugate vaccine. Infect Immun 71, 5402-5406. *shared senior authorship

Gor DO, Ding X, Briles DE, Jacobs MR, Greenspan, NS (2005). Relationship between surface accessibility for PpmA, PsaA, and PspA and antibody-mediated immunity to systemic infection by Streptococcus pneumoniae. Infec. Immun 73, 1304-1312.