Xingjun Fan, Ph.D.

Assistant Professor

Mailing Address:
2103 Cornell Rd.
WRB 5301
Cleveland, OH 44106-7288

phone: (216) 368-6238
fax: (216) 368-0494
email: Xing-Jun.Fan@Case.edu

Biography
Dr. Xingjun Fan received his B.S. from the Northwestern University (Xian, China) in 1993. He received his Ph.D from Lanzhou Institute of Chemical Physics, the Chinese Academy of Sciences in 1998. He had two years postdoctoral training at Shanghai Institute of Biochemistry, the Chinese Academy of Sciences. From 2000 to 2005, Dr. Fan had his postdoctoral training at Case Western Reserve University. Dr. Fan is currently an instructor in the department.

Research

  • By using knock in and knock out animal model to elucidate the molecular mechanisms by which the aging process leads to impairment of protein function, i.e. lens crystallin aging and cataractogenesis.

  • By using systematically knock in animal model to elucidate the possible mechanisms of prevention of proteinuria via enhancing the antioxidative capability in diabetic kidney.

  • Publications
    Xingjun FAN, Keguo Yuan, Nan Li, Xianda Yu, Ganzu Tan. The sythnthesis of some esters under microwave irradiation. Org. Prep. Proc. Int., 2000 54-59.

    Xingjun FAN, Jinmao You, Qinyu Ou. New reagents for determination of amino acids by liquid chromatography with pre-column fluorescence derivatization. Anal. Chim. Acta, 1998, 367, 81-91.

    Xingjun Fan, Jing Liu, Huiwei Tang, T. P. Wang, Youxin Jin. Determination PyPuPU intermolecular triple-strand helical DNA by capillary electrophoresis. Analytical Biochemistry, 2001, 287, 95-101.

    Ram Subramaniam Xingjun Fan, Petersen CE, Surewicz W, Bhagavan NV, Weiss MF, Vincent M. Monnier. Cellular oxidant stress and advanced glycation end products of albumin: caveats of the Dichlorofluorescein assay. Arch Biochem Biophys 2002, 400(10), 15-25.

    Xingjun Fan, Ram Subramaniam, Weiss MF, Vincent M. Monnier. Methylglyoxal-bovine serum albumin stimulates tumor necrosis factor alpha secretion in RAW 264.7 cells through activation of mitogen-activating protein kinase, nuclear factor kappaB and intracellular reactive oxygen species formation. Arch Biochem Biophys 2003, 409(2):274-86.

    Obrenovich ME, Xingjun Fan, Satake M, Jarvis SM, Reneker L, Reddan JR, Monnier VM. Relative suppression of the sodium-dependent Vitamin C transport in mouse versus human lens epithelial cells. Mol Cel Biochem 2006 Dec;293(1-2):53-62.

    Xingjun Fan, Reneker Lixing, Obrenovich ME, Strauch C, Cheng R, Jarvis SM, Ortwerth BJ, Monnier VM. Vitamin C mediates chemical aging of lens crystallins by the Maillard reaction in a humanized mouse model. Proc Natl Acad Sci U S A 2006 Nov 7;103(45):16912-7.

    Ozdemir AM, Hopfer U, Rosca MV, Fan XJ, Monnier VM, Weiss MF. Effects of advanced glycation end product modification on proximal tubule epithelial cell processing of albumin. Am J Nephrol. 2008;28(1):14-24.

    Dai Z, Wang B, Sun G, Fan X, Anderson VE, Monnier VM. Identification of Glucose-Derived Cross-Linking Sites in Ribonuclease A. J proteome Res 2008: 7(7):2756-2768.

    Yin S, Fan X, Yu S, Li C, Sy MS. J Bio Chem 2008 12;283(37):25446-54.

    Xingjun Fan, Christopher Strauch, Vincent Monnier. Nucleophilic compounds decrease crystallin ascorbylation in the hSVCT2 mouse model of lenticular aging. IOVS 2008 49(11): 4945-52.