Brian A. Cobb, Ph.D.Associate Professor
2103 Cornell Rd.
Cleveland, OH 44106-7288
phone: (216) 368-1263
fax: (216) 368-0494
Dr. Brian Cobb graduated with a B.S. in Biochemistry from the University of Oklahoma in 1995. The next five years were spent at Washington University, St. Louis, where he received his Ph.D. in Biochemistry studying the macromolecular interactions of the lens protein alpha crystallin with the plasma membrane. His three years as a postdoctoral fellow was spent as a dual appointment in the Department of Microbiology and Molecular Genetics and the Department of Medicine at Harvard Medical School (2001-04) working with Dennis Kasper on the innate and adaptive immune responses to commensal bacteria-derived capsular polysaccharides. He continued at Harvard for another year as an Instructor before coming to Case School of Medicine in 2005 where he is an Associate Professor in the Department of Pathology, and Director of the Immunology Training Program.
The Cobb lab is broadly focused on immune regulation and the role that carbohydrates (microbial and host) play in related mechanisms. As such, we work at the interface of glycobiology and immunology. The lab can be roughly broken into two areas of research: (1) polysaccharide antigens and the impact of these commensal flora-derived molecules on the susceptibility to develop immune-mediate diseases, such as asthma; and (2) the regulation of host glycosylation and the impact these glycans have upon immune regulatory pathways. Go to the Cobb Laboratory website for more information.
For the most recent list on Pubmed, click here.
Johnson, J.L., Jones, M.B., Cobb, B.A. (2014) "Polysaccharide A from the capsule of Bacteroides fragilis induces clonal CD4+ T cell expansion", Journal of Biological Chemistry 290(8), pp. 5007-5014. [Pubmed]
Johnson, J.L., Jones, M.B., Cobb, B.A. (2014) "Bacterial capsular polysaccharide prevents the onset of asthma through T cell activation", Glycobiology 25(4), pp. 368-375. [Pubmed]
Ryan, S.O., Abbott, D.W., Cobb, B.A. (2014) "Myeloid glycosylation defects lead to a spontaneous common variable immunodeficiency-like condition with associated hemolytic anemia and antilymphocyte autoimmunity", Journal of Immunology 192(12), pp. 5561-5570. [Pubmed]
Cobb, B.A. (2014) "Is donor glycosylation the gatekeeper for xenotransplantation?" American Journal of Transplantation 14(4), pp. 745-747. [Pubmed]
Taylor, P.R., Roy, S., Leal Jr., S.M., Sun, Y., Howell, S.J., Cobb, B.A., Li, X., Pearlman, E. (2014) "Activation of neutrophils by autocrine IL-17A-IL-17RC interactions during fungal infection is regulated by IL-6, IL-23, RORgt and Dectin-2", Nature Immunology 15(2), pp. 143-151. [Pubmed]
Ryan, S.O., Leal Jr., S.M., Abbott, D.W., Pearlman, E., Cobb, B.A. (2014) "Mgat2 ablation in the myeloid lineage leads to defective glycoantigen T cell responses", Glycobiology 24(3), pp. 262-271. [Pubmed]
Jun, J.C., Kertesy, S., Jones, M.B., Marinis, J.M., Cobb, B.A., Tigno-Aranjuez, J.T., Abbott, D.W. (2013) "Innate immune-directed NF-kB signaling requires site-specific NEMO ubiquitination", Cell Reports 4(2), pp. 352-361. [Pubmed]
Bloem, K., Garcia-Vallejo, J.J., Vuist, I.M., Cobb, B.A., van Vliet, S.J., van Kooyk, Y. (2013) "Interaction of the Capsular Polysaccharide A from Bacteroides fragilis with DC-SIGN on Human Dendritic Cells is Necessary for Its Processing and Presentation to T cells", Frontiers in Immunology 4(Article 103). [Pubmed]
Ryan, S.O., Johnson, J.L., Cobb, B.A. (2013) "Neutrophils Confer T cell Resistance to Myeloid-Derived Suppressor Cell-Mediated Suppression to Promote Chronic Inflammation", Journal of Immunology 190(10), pp. 5037-5047. [Pubmed]
Johnson, J.L., Jones, M.B., Ryan, S.O., Cobb, B.A. (2013) "The Regulatory Power of Glycans and their Binding Partners in Immunity", Trends in Immunology 34(6), pp. 290-308. [Pubmed]
Xiao, X., Yuan, J., Haik, S., Cali, I., Zhan, Y., Li, B., Moudjou, M., Laplanche, J-L., Laude, H., Langeveld, J., Gambetti, P., Kitamoto, T., Kong, Q., Cobb, B.A., Brandel, J-P., Petersen, R.B., Zou, W-Q. (2013) "Glycoform-Selective Prion Formation in Sporadic and Familial Forms of Prion Disease", PLOS One 8(3): e58786. [Pubmed]
Leal Jr., S.M., Vareechon, C., Cowden, S., Cobb, B.A., Latge, J-P., Momany, M., Pearlman, E. (2012) "Fungal Antioxidant Pathways Promote Survival Against Neutophils During Infection", Journal of Clinical Investigation 122(7), pp. 2482-2498. [Pubmed]
Taylor, C.E., Cobb, B.A., Rittenhouse-Olson, K., Paulson, J., Schreiber, J.R. (2012) "Carbohydrate Moieties as Vaccine Candidates: Targeting the Sweet Spot in the Immune Response", Vaccine 30(30), pp. 4409-4413. [Pubmed]
Marinis, J.M., Hutti, J.E., Homer, C.R., Cobb, B.A., Cantley, L.C., McDonald, C., Abbott, D.W. (2012) "IkB Kinase alpha Phosphorylation of TRAF4 Down-Regulates Innate Immune Signaling", Molecular Cell Biology 32(13), pp. 2479-2489. [Pubmed]
Ryan, S.O. and Cobb, B.A. (2012) "Roles for Major Histocompatibility Complex Glycosylation in Immune Function", Seminars in Immunopathology special volume on Glycosylation and Immunity 34(3), pp. 425-441. [Pubmed]
Rabinovich, G.A., van Kooyk, Y., Cobb, B.A. (2012) "Glycobiology of immune responses", Annals of the New York Academy of Sciences 1253(1), pp. 1-15. [Pubmed]
Ryan, S.O. and Cobb, B.A. (2012) "Host Glycans and Antigen Presentation", Microbes and Infection 14, pp. 894-903. [Pubmed]
Kreisman, L.S.C. and Cobb, B.A. (2012) "Infection, Inflammation, and Host Carbohydrates: A Glyco-Evasion Hypothesis", Glycobiology 22(8), pp. 1019-1030. [Pubmed]
Lewis, C.J. and Cobb, B.A. (2011) "Adaptive Immune Defects Against Glycoantigens in Chronic Granulomatous Disease via Dysregulated Nitric Oxide Production", European Journal of Immunology 41(9), pp. 2562-2572. [Pubmed]
Cobb, B.A., Rabinovich, G.A., van Kooyk, Y. (2011) "State of the Union: Glycobiology and Immunology in the Canadian Rockies", Glycobiology 21(5), pp. 545-546. [Pubmed]
Young, N.M., Kreisman, L.S.C., Stupak, J., Maclean, L.L., Cobb, B.A., Richards, J.C. (2011) "Structural characterization and MHCII-dependent immunological properties of the zwitterionic O-chain antigen of Morganella morganii", Glycobiology 21(10), pp. 1266-1276. [Pubmed]
Ryan, S.O., Bonomo, J.A., Zhao, F., Cobb, B.A. (2011) "MHCII Glycosylation Modulates Bacteroides fragilis Carbohydrate Antigen Presentation", Journal of Experimental Medicine 208(5), pp. 1041-1053. [Pubmed]
Kreisman, L.S.C. and Cobb, B.A. (2011) "Glycoantigens Induce Human Peripheral Tr1 Cell Differentiation with Gut-homing Specialization", Journal of Biological Chemistry 286(11), pp. 8810-8818. [Pubmed]
Ramachandra, L., Qu, Y., Wang Y., Lewis, C.J., Cobb, B.A., Takatsu, K., Boom, W.H., Dubyak, G.R., Harding, C.V. (2010) "Mycobacterium tuberculosis synergizes with ATP to induce release of microvesicles and exosomes containing MHC-II molecules capable of antigen presentation", Infection and Immunity 78(12), pp. 5116-5125. [Pubmed]
Lewis, C.J. and Cobb, B.A. (2010) "Carbohydrate Oxidation Acidifies Endosomes, Regulating Antigen Processing and TLR9 Signaling", Journal of Immunology 184, pp. 3789-3800. [Pubmed]
Brokaw, A., Cobb, B.A. (2009) "A Simple Test Tube-Based ELISA Experiment for the High School Classroom", Biochemistry and Molecular Biology Education 37(4), pp. 243-248. [Pubmed]
Cobb, B.A. (2009) "Immunology and the biomedical student pipeline", European Journal of Immunology 39(5), pp. 1183-1186. [Pubmed]
Velez, C.D., Lewis, C.J., Kasper, D.L., Cobb, B.A. (2008) "Type 1 Streptococcus pneumoniae carbohydrate utilizes a nitric oxide and MHCII-dependent pathway for antigen presentation", Immunology 127(1), pp. 73-82. [Pubmed]
Clark, N.M., Marinis, J.M., Cobb, B.A., Abbott, D.W. (2008) "MEKK4 sequesters RIP2 to dictate NOD2 signal specificity", Current Biology 18(18), pp. 1402-1408. [Pubmed]
Cobb, B.A., Kasper, D.L. (2008) "Characteristics of carbohydrate antigen binding to the presentation protein HLA-DR", Glycobiology 18(9), pp. 707-718. [Pubmed]
Kreisman, L.S.C., Friedman, J.H., Neaga, A., Cobb, B.A. (2007) “Structure-Function Relationships with a T cell Activating Polysaccharide Antigen using Circular Dichroism”, Glycobiology 17(1), pp. 46-55. [Pubmed]
Wang, Q., McLoughlin, R.M., Cobb, B.A., Charrel-Dennis, M., Zaleski, K.J., Golenbock, D., Tzianabos, A.O., Kasper, D.L. (2006) "A bacterial carbohydrate links innate and adaptive responses through Toll-like receptor 2", Journal of Experimental Medicine 203(13), pp. 2853-2863. [Pubmed]
Cobb, B.A., Kasper, D.L. (2005) "Zwitterionic Capsular Polysaccharides: The New MHCII-Dependent Antigens", Cellular Microbiology 7(10), pp. 1398-1403. [Pubmed]
Cobb, B.A., Kasper, D.L. (2005) "Coming of Age: Carbohydrates and Immunity", European Journal of Immunology 35(2), pp. 352-356. [Pubmed]
Cobb, B.A., Wang, Q., Tzianabos, A.O., Kasper, D.L. (2004) "Polysaccharide Processing and Presentation by the MHCII Pathway", Cell 117(5), pp. 677-87. [Pubmed]
Cobb, B.A., Petrash, J.M. (2001) "Alpha-Crystallin Chaperone-Like Activity and Membrane Binding in Age-Related Cataracts", Biochemistry 41, pp. 483-90. [Pubmed]
Cobb, B.A., Petrash, J.M. (2000) "Structural and Functional Changes in the alphaA-crystallin R116C Mutant in Hereditary Cataracts", Biochemistry 39, pp. 15791-8. [Pubmed]
Cobb, B.A., Petrash, J.M. (2000) "Characterization of alpha-Crystallin-Plasma Membrane Binding", Journal of Biological Chemistry 275(9), pp. 6664-72. [Pubmed]
Stock, M.F., Guerrero, J., Cobb, B., Eggers, C.T., Huang, T-G, Li, X., Hackney, D.D. (1999) "Formation of the Compact Confomer of Kinesin Requires a COOH-terminal Heavy Chain Domain and Inhibits Microtubule-Stimulated ATPase Activity", Journal of Biological Chemistry 274(21), pp. 14617-23. [Pubmed]
Third-Party News and Views
(2011) "The curious case of nitric oxide and CGD", In this issue. European Journal of Immunology 41(9), pp. 2465-2466. [Link]
Watts, C. (2004) "Class II MHC: Sweetening the Peptide-Only Diet?", Cell 117(5), pp. 558-9. [Pubmed]
Honey, K. (2004) "Presenting a Newly Charged Antigen", Nature Reviews Immunology 4, pg. 489.
Hurtley, S.M. (2004) "Immunology: Sweet Presentation", Science 304, pg. 1719.
Dempsey, L.A. (2004) "Processed Sugar", Nature Immunology 5(7), pg. 693.