David H. Canaday, M.D.

Associate Professor
Associate Director of Research
Geriatric Research, Education and Clinical Center (GRECC)
Louis Stokes Cleveland VA Medical Center
Division of Infectious Disease, Case Western Reserve University

Mailing Address:
10900 Euclid Ave.
BRB 1022
Cleveland, OH 44106-4984

Office phone: (216) 368-8901
Lab (VA): (216) 791-3800 Ext. 4618
Lab (CWRU): (216) 368-0344
Fax: (216) 368-2034
Pager: (216) 464-8410 #35324
email: dxc44@Case.edu
Skype: canaday66

Biography
David Canaday graduated from the University of Pennsylvania in 1988 with a B.A. in Biology. He then entered Washington University School of Medicine and graduated in 1992. He went on to do an Internal Medicine residency of the University of Minnesota and then finished his training here at Case Western Reserve Univeristy and University Hospitals of Cleveland as an Infectious Disease fellow from 1995-1999. He trained in the lab of Dr. Henry Boom and also had Dr. Clifford Harding as a co-mentor on his K08 grant focusing on the pathogenesis of M. tuberculosis. Dr. Canaday joined the CWRU faculty in 2000 in the Division of Infectious Disease. He has increased his time and effort at the Cleveland VA becoming a member of the Geriatric Research, Education and Clinical Center (GRECC) in 2008 and ultimately the Associate Director of Research in the GRECC in 2010. Dr. Canaday sees patients at the Cleveland VA on the inpatient Medical service and Infectious Disease consultation service. He has active laboratories at both CWRU and the VA.

Research
Dr. Canaday's laboratory works in the area of aspects of human immunity to infectious diseases. He focuses primarily on two areas. The first is understanding the mechanisms of increased pathogenesis during HIV/TB co-infection specifically involving properties of the interactions of T cells with macrophages and dendritic cells that fosters loss of control of TB infection. This work takes place at CWRU and also in collaboration with the TB Research Unit (TBRU) both here and in Kampala, Uganda. The second focus is to determine defects in the human immune system that occur with aging. One current aspect of this project is trying to determine predictors of influenza and shingles vaccination failure in older adults.

Publications
Canaday DH, Ziebold C, Noss E, Chervenak KA, Harding CV, Boom WH. Activation of human CD8+ ab+ TCR+ T cells by M. tuberculosis via an alternate class I MHC antigen processing pathway. Journal of Immunology. 162:372-9, 1999.

Canaday DH, Wilkinson RJ , Li Q, Clifford V Harding CV, Silver RF, WH Boom. CD4+ and CD8+ T cells kill intracellular M. tuberculosis by a perforin and FAS/FASL independent mechanism. Journal of Immunology. 167:2734-2742, 2001.

Canaday DH, Gehring A, Leonard EG, Eilertson B, Schreiber JR, Harding CV, Boom WH. T cell hybridomas from HLA-transgenic mice as tools for analysis of human antigen processing. Journal of Immunological Methods. 281: 129-142, 2003.

Tobian AR, Harding CV*, Canaday DH*. Mycobacterium tuberculosis heat shock protein enhances class I MHC cross processing and presentation by B lymphocytes. Journal of Immunology. 174: 5209-5214. 2005.

Zhou D, Li P, Lin Y, Lott JM, Canaday DH, Brutkiewicz RR, Blum JS. Lamp-2a facilitates MHC class II presentation of cytoplasmic antigens. Immunity. 22:571-81, 2005.

Jones LJ, McDonald DM, Canaday DH. Rapid MHC-II antigen presentation of HIV-1 by dendritic cells. AIDS research and Human Retroviruses. AIDS Res Hum Retroviruses. 23:812-6. 2007.

Woc-Colburn L, Smultea L, Ramachandra L, Canaday DH. Preserved MHC class II antigen processing in monocytes from HIV-infected individuals. PLoS One. 2010 Mar 3;5(3):e9491.

Canaday DH, Amponsah NA, Jones L, Tisch DJ. Hornick TR, Ramachandra L. Influenza-induced production of interferon-alpha is defective in geriatric individuals. Journal of Clinical Immunology. 30:373-83. 2010.

Reuter M, Canaday DH, McDonald D. Mycobacterium tuberculosis promotes HIV trans-infection and suppresses antigen processing by dendritic cells. Journal of Virology, 84(17):8549-60. 2010.

El Fenniri L, Toossi Z, Aung H, El Iraki G, Bourkkadi J, Benamor J, Laskri A, Berrada N, Benjouad A, Mayanja-Kizza H, Betts MR, El Aouad R, Canaday DH*. Polyfunctional M. tuberculosis-specific effector memory CD4+ T cells at sites of pleural TB. Tuberculosis. 91:224-30. 2011.

Bartley M, Canaday DH. T cell hybridomas to study MHC-II restricted B-cell receptor-mediated antigen presentation by human B cells. Journal of Immunological Methods. 370: 35–42. 2011.

Lee JB, Oelke M, Ramachandra L, Canaday DH, Jonathan P. Schneck. Decline of influenza-specific CD8+ T cell repertoire in healthy geriatric donors. Immunity and Ageing. 2011 Aug 16;8(1):6.

*shared Senior author