Rose C. Beck, M.D., Ph.D.

Assistant Professor

Mailing Address:
2103 Cornell Rd.
WRB 6526
Cleveland, OH 44106-7288

phone: (216) 844-8253
fax: (216) 844-5601
email: Rose.Beck@UHHospitals.org

Biography
Dr. Rose Beck received her B.A. from Mary Baldwin College in Staunton, Virginia (1992). She went on to earn her M.D. and Ph.D. from Case in 2001. Her residency in Clinical Pathology was completed at The Cleveland Clinic Foundation, where she also finished a fellowship in Hematopathology from 2004 to 2005.

Research
Clinical interests: hematopathology, laboratory hematology
Research interests: NK cell therapy in the setting of hematologic malignancy and bone marrow transplantation

Publications
Griffin JP, Chu R, Harding CV: Early endosomes and a late endocytic compartment generate different peptide-class II MHC complexes via distinct processing mechanisms. J Immunol 1997; 158:1523-1532.

Chu RS, Targoni OS, Krieg AM, Lehmann PV, Harding CV: CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity. J Exp Med 1997; 186:1623-1631.

Chu RS, Askew D, Noss EH, Tobian A, Krieg AM, Harding CV: CpG oligodeoxynucleotides down-regulate macrophage class II MHC antigen processing. J Immunol 1999; 163:1188-1194.

Ramachandra L, Chu RS, Askew D, Noss EH, Canaday DH, Potter NS, Johnsen A, Krieg AM, Nedrud JG, Boom WH, Harding CV: Phagocytic antigen processing and effects of microbial products on antigen processing. Immunological Rev 1999; 168: 217-239.

Chu RS, Askew D, Harding CV: CpG DNA switches on Th1 immunity and modulates antigen presenting cell function. Curr Top Microbiol Immunol 2000; 247:199-210.

Chu RS, Krieg AM, Greenspan NS, Schreiber JR, Harding CV: CpG oligodeoxynucleotides act as adjuvants for polysaccharide-protein conjugate vaccines and selectively enhance anti-polysaccharide IgG2a and IgG3. Infect and Imm 2000; 68:1450-1456.

Askew D, Chu RS, Krieg AM, Harding CV: CpG DNA induces maturation of dendritic cells with distinct effects on nascent and recycling MHC-II antigen processing mechanisms. J Immunol 2001; 165:6889-6895.

Beck RC, Tubbs RR, Hussein M, Pettay J, Hsi ED: Automated colorimetric in situ hybridization (CISH) detection of immunoglobulin (Ig) light chain mRNA expression in plasma cell (PC) dyscrasias and non- Hodgkin lymphoma. Diag Mol Pathol 2003; 12:14-20.

Beck RC, Stahl S, O'Keefe CL, Maciejewski JP, Theil KS, Hsi, ED: Detection of mature T cell leukemias by flow cytometry using anti-T cell receptor Vbeta antibodies. Am J Clin Pathol 2003; 120:785-94.

Beck RC, Kohn DJ, Tuohy MJ, Prayson RA, Yen-Lieberman B, Procop GW: Detection of polyoma virus in brain tissue of patients with progressive multifocal leukoencephalopathy by real-time PCR and pyrosequencing. Diag Mol Pathol 2004; 13:15-21.

Beck RC, Wlodarski M, Theil KS, Tuthill RJ, Bolwell B, Maciejewski JP: Efficient identification of T- cell clones associated with graft-versus-host disease in target tissue allows for subsequent detection in peripheral blood. Brit J Haematol 2005; 129:411-419.