James M. Anderson, M.D., Ph.D.

Distinguished University Professor
Professor of Pathology, Macromolecular Science, and Biomedical Engineering

Mailing Address:
2103 Cornell Rd.
WRB 5105
Cleveland, OH 44106-7288

phone: (216) 368-0279
fax: (216) 368-0494
email: James.Anderson@Case.edu

Biography
Dr. James Anderson received his Ph.D. at Oregon State University in 1967. In 1976, he graduated from the Case Western Reserve University School of Medicine with an M.D. degree and finished his Anatomic Pathology residency at the Institute of Pathology of University Hospitals of Cleveland in 1979. Following the completion of his residency, Dr. Anderson joined the faculty of the Institute of Pathology at Case Western Reserve University. Dr. Anderson has worked in the area of biomaterials, medical devices, and prostheses for the past 40 years and his current activities range from the clinical pathology evaluation of retrieved implants from humans to fundamental studies of cellular interactions with biomaterials. Dr. Anderson is the recipient of a NIH MERIT (Method to Extend Research In Time) Award (1993 to 2003). He is a founding member of the Society for Biomaterials and the Controlled Release Society and serves as a consultant to the National Institutes of Health Artificial Heart Program, the Food and Drug Administration, and the International Standards Organization where he is the Co-Chair of Working Group 1 for the development of the ISO Standard on Biological Evaluation of Medical Devices, ISO 10993. He is the Editor-in-Chief of the Journal of Biomedical Materials Research. In 2003, he was elected to the Institute of Medicine of the National Academies of Science. In 2005, Dr. Anderson received the Elsevier Biomaterials Gold Medal Award given to the individual who has made the most significant contributions to biomaterials science over the 25 year period from 1980 to 2005. He received this award at the Tissue Engineering Science International Conference held in Shanghai, China, in October of 2005. Dr. Anderson is the recipient of the 2006 Chugai Mentoring Award given by the American Society for Investigative Pathology to senior investigators who have distinguished their careers with a dedication to mentoring and education. In 2006, Dr. Anderson was awarded the Honoris Causa Degree (honorary Doctorate of Philosophy Degree) by the University of Geneva, Switzerland. In 2008, Dr. Anderson was elected to the American Association of Physicians. Dr. Anderson was elected Fellow of the American Association for the Advancement of Science (AAAS) in 2011. In 2012, Dr. Anderson was awarded the title of Distinguished University Professor by Case Western Reserve Unviersity. He is the recipient of the 2013 Acta Biomaterlia Gold Medal for his contributions to biomaterial science and engineering and was elected to the National Academy of Engineering (NAE) in 2013.

Research
Our research efforts are centered around the development of a better understanding of blood and tissue/material interactions as they relate to implantable devices and biomaterials. The overall focus of our efforts is on the cellular and humoral responses to implanted materials. Studies currently ongoing include an analysis of the wound healing response to vascular graft materials, in vivo biocompatibility testing with the focus on macrophage and foreign body giant cell adhesion and activation, and a determination of those factors which lead to the biodegradation of biomaterials. In addition, we are investigating human blood/material interactions using an in vitro system and interrelating variations in protein adsorption, cellular components, coagulation parameters, platelet activation and release, and complement activation.

Publications
Refereed Journals
Anderson, James, Elizabeth M. Christenson, and Anne Hiltner, Biodegradation mechanisms of polyurethane elastomers, Corrosion Engineering Science and Technology, 2007;42(4):312-323.

Jones, J.A., A. McNally, D.T. Chang. L.A. Qin, H. Meyerson, E. Colton, I.K. Kwon, T. Matsuda, and J.M. Anderson, Matrix metalloproteinases and their inhibitors in the foreign body reaction on biomaterials, J. Biomed. Mater. Res. A. 2008;84A(1):158-166.

Rodriguez, A., G. Voskerician, H. Meyerson, S.R. MacEwan, and J.M. Anderson, T cell subset distributions following primary and secondary implantation at subcutaneous biomaterial implant sites, J. Biomed. Mater. Res. A. 2008; 85A(2):556-565.

Jones, J.A., L.A. Qin, H. Meyerson, I.K. Kwon, T. Matsuda, and J.M. Anderson, Instability of self-assembled monolayers (SAM) as a model material system for macrophage/FBGC cellular behavior, J. Biomed. Mater. Res. A. 2008;86A(1):261-268.

McNally, Amy K., Jacqueline A. Jones, Sarah R. MacEwan, Erica Colton, and James M. Anderson, Vitronectin is a critical protein adhesion substrate for IL-4-induced foreign body giant cell formation, J. Biomed. Mater. Res. A. 2008;86A(2):535-543.

Chang, David T., Jacqueline A. Jones, Howard Meyerson, Erica Colton, Il Keun Kwon, Takehisa Matsuda, and James M. Anderson, Lymphocyte/macrophage interactions: Biomaterial surface-dependent cytokines, chemokine, and matrix protein production, J. Biomed. Mater. Res. A, 2008;87A(3):676-687.

Anderson, James M., Analiz Rodriguez, and David T. Chang, Foreign body reaction to biomaterials, Seminars in Immunology, 2008;20(2):86-100.

Abbas, R., S. Adam, S. Okadal, H. Groar, J. Anderson, and J. Sanabria, The development of a swine model of secondary liver tumor from a genetically induced swine fibroblast cell line, HPB (Oxford), 2008;10(3):204-210.

Rodriguez, A., H. Meyerson, and J.M. Anderson, Quantitative in vivo cytokine analysis at synthetic biomaterial implant sites, J. Biomed. Mater. Res. A, 2008;89(1):152-159.

McNally, Amy K., Sarah R. MacEwan, and James M. Anderson, Foreign body-type multinucleated giant cell formation requires protein kinase C β, δ, and ζ, Exp. Mol. Pathol., 84 (2008) 37-45.

Brodbeck, William G. and James M. Anderson, Giant cell formation and function, Curr. Opin. In Hematology, 2009, 16:53-57.

Rodriguez, Analiz, Sarah R. MacEwan, Howard Meyerson, James T. Kirk, and James M. Anderson, The Foreign body reaction in T cell deficient mice, J. Biomed. Mater. Res., 2009;90A:106-113, PMID 18491378.

Chang, David T., Erica Colton, and James M. Anderson, Paracrine and juxtacrine lymphocyte enhancement of adherent macrophage and foreign body giant cell activation, J. Biomed. Mater. Res. A, 2009;89A(2):490-498, PMID 18437695.

Chang, David T., Erica Colton, Takehisa Matsuda, and James M. Anderson, Lymphocyte adhesion and interactions with biomaterial adherent macrophages and foreign body giant cells, J. Biomed. Mater. Res. A, 2009;91A:1210-1220. PMID 19148923.

Kumar Das, Gautom, Peggy P.Y. Chan, Ailing Teo, Joachim Say Chye Loo, James M. Anderson, Timothy Thatt Yang Tan, In vitro cytotoxicity evaluation of biomedical nanoparticles and their extracts, J. Biomed. Mater. Res. A, 2010;93A(1):337-346.

Mukherjee, Pranab K., David V. Chand, Jyotsna Chandra, James M. Anderson, and Mahmoud A. Ghannoum, Shear stress affects the architecture of Candida albicans biofilms, Mycoses, 2009;52(5):440-446.

Chang, David T., Gerald M. Saidel, and James M. Anderson, Dynamic systems model for lymphocyte interactions with macrophages at biomaterial surfaces, Cellular and Molecular Engineering, 2009;2(4):573.

Rodriguez, Analiz, Howard Meyerson, and James M. Anderson, Evaluation of clinical biomaterial surface effects on T lymphocyte activation, J. Biomed. Mater. Res. 2010;92A1:214-220.

Chen, Sulin, Jacqueline A. Jones, Yongan Xu, Hong-Yee Low, James M. Anderson, and Kam W. Leong, Characterization of topographical effects on macrophage behavior in a foreign body response model, Biomaterials, 31 (2010) 3479-3491.

Cao, Haoqing, Kevin McHugh, Sing Yian Chew, James M. Anderson, The Topographical Effect of Electrospun Nanofibrous Scaffolds on the In Vivo and In Vitro Foreign Body Reaction, J. Biomed. Mater. Res. A., 2010;93A3:1151-1159. DOI: 32609.

Knight, Pamela T., James T. Kirk, James M. Anderson, Patrick T. Mather, In vivo kinetic degradation analysis and biocompatibility of aliphatic polyester polyurethanes, J. Biomed. Mater. Res. A, 2010;94A2:333-343. DOI:32806.

Kirk, J. T., A. K. McNally, and J. M. Anderson. Polymorphonuclear leukocyte inhibition of monocytes/macrophages in the foreign body reaction, J. Biomed. Mater. Res. A., 2010;94A(3):683-687.

Leong, Meng Fatt, Wing Yue Chan, James M. Anderson, and Kerm Sin Chian, Fabrication and in vitro and in vivo cell infiltration study of a bilayered cryogenic electrospun poly(D,L-lactide) scaffold (BLES), J. Biomed. Mater. Res.-A, 2010;94A(4):1141-1149. DOI: 32795.

Jinno, S., B.M. Gripshover, T.L. Lemonovich, J.M. Anderson, and M. R. Jacobs, Histoplasma capsulatum prosthetic valve endocarditis with negative fungal blood cultures and negative histoplasma antigen assay in an immunocompetent patient, J. Clin. Microbiol. 2010;48:4664-4666.

Bao, Haifeng, Zhisong Lu, Xiaoqiang Cui, Yan Qiao, Jun Guo, James M. Anderson, and Chang Ming Li, Extracellular microbial synthesis of biocompatible CdTe quantum dots, Acta Biomaterialia. 2010;6:3534-3541.

Luca, Ludmila, Anne-Laure Rougemont, Beat H. Walpoth, Ludovic Boure, Andrea Tami, James M. Anderson, Olivier Jordan, and Robert Gurny, Injectable rhBMP-2-loaded chitosan hydrogel composite: osteoinduction at ectopic site and in segmental long bone defect, J. Biomed. Mater. Res.-A. 2011;96A1:66-74.

Reichert, W.M., B.D. Ratner, J. Anderson, A. Coury, A.S. Hoffman, C.T. Laurencin, and D. Tirell. Society for Biomaterials: 2010 Panel on The Biomaterials Grand Challenges, J. Biomed. Mater. Res. 2011;96A2:275-287.

Anderson, James M. and Amy K. McNally, Biocompatibility of implants: Lymphocyte/macrophage interactions, Seminars in Immunopathology, 2011;33(3):221-233.

Hofmann, Christopher M., Kyle J. Bednar, James M. Anderson, Roger E. Marchant, Disruption of Staphylococcus epidermidis biofilm formation using a targeted cationic peptide, J. Biomed. Mater. Res., 2012;100A(4):1061-1067.

Ji, W., F. Yang, H. Seyednejad, Z. Chen, W.E. Hennink, J.M. Anderson, J.J.J.P. van den Beucken, and J.A. Jansen. Biocompatibility and degradation characteristics of PLGA-based electrospun nanofibrous scaffolds with nanoapatite incorporation, Biomaterials 33 (2012) 6604-6614.

Patel, J. D., E. Colton, M. Ebert, and J.M. Anderson, Gene expression during S. epidermidis biofilm formation on biomaterials, J. Biomed. Mater. Res.,2012, published on-line 24 May, DOI: 10.1002/jbm.a.34221.

Hofmann, Christopher M., James M. Anderson, and Roger E. Marchant, Targeted delivery of Vancomycin to Staphylococcus epidermidis biofilms using a fibrinogen-derived peptide, J. Biomed. Mater. Res., 2012;100A(9):2517-2525, Published on-line 24 May, DOI:1002/jbm.a.34166.

Farra, Robert, Norman F. Sheppard, Laura McCabe, Robert M. Neer, James M. Anderson, John T. Santini, Jr., Michael J. Cima, and Robert Langer, First-in-human testing of a wirelessly controlled drug delivery microchip, Science-Transl. Med., 2012;22 4:122ra21. DOI: 10.1126/scitrnaslmed.3003276.

Rujitanaroj, P., B. Jao, J. Yang, F. Wang, J.M. Anderson, J. Wang, and S.Y. Chew, Controlling fibrous capsule formation through long-term down-regulation of collagen type I (COL1A1) expression by nanofiber-mediated siRNA gene silencing, Acta Biomaterialia, 2012 (submitted).

Harth, Karem C., Jeffrey A. Blatnik, James M. Anderson, Michael R. Jacobs, Farhad Zeinali, and Michael J. Rosen, Effect of surgical wound classification on biologic graft performance in complex hernia repair: An experimental study, Surgery, 2013;153(4):481-492.

Book Chapters
Anderson, James M., Biocompatibility and Bioresponse to Biomaterials, in Principles of Regenerative Medicine, A. Atala, R. Lanza, J.A. Thomson, R.M. Nerem, editors, Elsevier/Academic Press, 2008, pp. 704-723.

Anderson, James M. and William G. Brodbeck, Local Tissue Responses to Polymer Implants Affecting Pharmacokinetics, Pharmacodynamics and Metabolism of Proteins and Peptides, in Proteins and Peptides: Pharmacokinetic, Pharmacodynamic and Metabolic Outcomes, R. Mrsny and A. Daugherty, editors, Informa Healthcare Publishers, New York, 2009.

Anderson, James M. and William G. Brodbeck, In Vitro and In Vivo Monocyte, Macrophage, Foreign Body Giant Cell and Lymphocyte Interactions with Biomaterials, in Biological Interactions on Materials Surfaces: Understanding and Controlling Protein, Cell, and Tissue Responses, R. Bizios and D. Puleo, editors, Springer, New York, 2009.

Anderson, James M., Biocompatibility and Bioresponse to Biomaterials, in Foundations of Regenerative Medicine, Anthony Atala, Robert Lanza, James A. Thompson, and Robert M. Nerem, editors, Elsevier/Academic Press, 2009, pp. 378-397.

Anderson, James M., Biocompatibility, in Polymer Science: A Comprehensive Reference, K. Matyzaszewski and M. Moeller, editors, Elsevier, Oxford, Chapter 9.19, 2011.

Anderson, James M., Biocompatibility and the Relationship to Standards: Meaning and Scope of Biocompatibility, in Comprehensive Biomaterials, P. Ducheyne, K.E. Healy, D.W. Hutmacher, D.W. Grainger, and C.J. Kirkpatrick, editors, Elsevier, Oxford, 2011, vol 4, pp. 7-26.

McNally, Amy K. and James M. Anderson, Macrophage Fusion and Multinucleated Giant Cells of Inflammation, in Cell Fusion in Health and Disease, Advances in Experimental Medicine and Biology 713, T. Dittmar and K.S. Zänker, Eds., Springer Science+Business Media B.V. 2011, pp. 97-111.

Anderson, James M., Host Response to Long Acting Injections and Implants, Chapter 3 in Long Acting Injections and Implants, J.C. Wright and D.J. Burgess, eds., Advances in Delivery Science and Technology, DOI 10.1007/978-1-4614-0554-2_3, 2011, pp. 25-55.

Anderson, James M., Inflammation, Wound Healing, and The Foreign-Body Response, in Biomaterials Science, An Introduction to Materials in Medicine, 3rd edition, B.D. Ratner, A.S. Hoffman, F.J. Schoen, J.E. Lemons, Eds., Elsevier Academic Press, 2013, pp. 503-512.

Anderson, James M. and Frederick J. Schoen, In Vivo Assessment of Tissue Compatibility, in Biomaterials Science, An Introduction to Materials in Medicine, 3rd edition, B.D. Ratner, A.S. Hoffman, F.J. Schoen, J.E. Lemons, Eds., Elsevier Academic Press, 2013, pp. 609-617.

Anderson, James M., Frederick J. Schoen, Stanley A. Brown, and Katharine Merritt, Implant Retrieval and Evaluation, in Biomaterials Science, An Introduction to Materials in Medicine, 3rd edition, B.D. Ratner, A.S. Hoffman, F.J. Schoen, J.E. Lemons, Eds., Elsevier Academic Press, 2013, pp. 1368-1383.

Anderson, James M. and Jasmine D. Patel, Chapter 7. Biomaterial Dependent Characteristics of the Foreign Body Response and S. Epidermidis Biofilm Interactions, in Medical Device Associated Infection, F. Moriarty, S. Zaat, and H. Busscher, Eds., Springer, 2013, pp. 114-150.

Wolf, M.F. and J.M. Anderson, Blood Compatibility Assessment in Medical Devices: Considerations and Standards, in Biocompatibility and Performance in Medical Devices, Jean-Pierre Boutrand, Ed., Woodhead Publishing Inc., 2012, pp. 159-200.