| FACULTY RESEARCH | |
The research conducted in the CASE Department of Nutrition emphasizes Nutritional Biochemistry & Metabolism, Molecular Nutrition, and Applied Nutrition. This research has been conducted in association with several Cleveland hospitals and other departments within the School of Medicine. Particular areas of Applied Nutrition have been developed and performed in field settings - both the United States and abroad, in cooperation with multicenter national studies, and in our own department's various laboratories. These state-of-the-art laboratories are located in the School of Medicine and the Veteran Affairs Medical Center. Facilities in the Clinical Research Center at University Hospitals Case Medical Center are also available to our department. CASE Nutrition department has all general equipment necessary for conducting studies in nutritional biochemistry and molecular nutrition, including six Agilent Technologies GC-MS (gas chromatographers -mass spectrometers). They are used for human and animal investigation with stable isotopes. Facilities for isolated organ perfusions and a comprehensive organic chemistry laboratory for synthesis of new nutrients are also available. The department has been equipped for body composition measures and diet preparation. Consult the Nutrition Faculty Directory for specific research projects. A synopsis of each faculty's research focus is shown below. Please click on the individual faculty's name to link into their respectiveprofilepage. |
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Regulation of the pathways of fatty acid oxidation, ketone body metabolism, citric acid cycle and gluconeogenesis. |
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Nutritional management of chronic liver diseases, glucose metabolism, sports nutrition and food safety. |
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Metabolic pathways in liver, muscle, adipose and pancreatic tissues. Molecular changes in animal pancreas models (resistant or sensitive to obesity in response to environmental stresses. |
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Nutrition and cardiovascular diseases; nutrient-drugs interactions; metabolic pharmacology; genetic obesity; lipids in cell signaling. |
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Molecular mechanisms regulation of gene expression during stress. |
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Public Health Nutrition |
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Cancer Survivorship, Weight Management and the Practice of Dietetics. |
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Mitochondrial fatty acid oxidation and the regulation of pathway by malonyl-CoA. |
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Weight management; Diabetes; Wellness Promotion/Disease Prevention and Control. |
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Assessment of nutritional status during pregnancy; Trace mineral metabolism during pregnancy; Neonatal patients. |
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Molecular-level treatment and prevention of cancer. |
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Effects of environmental factors such as diet, alcohol and drugs on cellular signal transduction mechanism. |
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Nutritional anthropology; maternal and child nutrition; public health nutrition; child growth and schistosomiasis. |
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Metabolomics; brain and body energy metabolism; regulation of fatty acid, ketone body and glucose metabolism; mass spectrometry. |
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Nutritional status & dietary intake assessment, chronic kidney disease. |
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Influence of dietary iron on intestinal tumorigenesis. |
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Research focus is on a new pathway which involves a new class of acyl-CoA esters and catabolizes 4-hydroxyacids, such as products of lipid peroxidation and drugs-of-abuse |
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