Guo-Fang Zhang, PhD

Assistant Professor






    Guofang Zhang received his B.S. and M.S. (both in Chemistry) from Shaanxi Normal University (China) in 1995 and 1998, respectively. In 2001, Guofang earned his Ph.D. in Chemistry from Nanjing University (China). Soon after, Dr. Zhang moved to Belgium with his wife Shuang. There he attended Vrije Universiteit Brussel and earned a Masters in Molecular Biology and Biotechnology.  From 2001 to 2006, Dr. Zhang was a postdoc at Gent University simultaneously in Dr. Willy Lambert's Toxicology Lab (within the Department of Bioanalysis) and in Prf. Van Der Straeten's Functional Plant Biology Lab (within the Department of Physiology).

    In June 2006, Guofang Zhang joined the Department of Nutrition at Case Western Reserve University School of Medicine as a Research Associate  in Dr. Brunengraber's Nutritional Biochemistry and Metabolism Lab.  He was appointed Assistant Professor in 2010. 



    My group investigates the regulation of new pathways which catabolize 4-hydroxyacids. These compounds are products of lipid peroxidation (such as 4-hydroxynonenal and 4-hydroxyhexenal) and drugs of abuse (4-hydroxybutyrate and 4-hydroxypentanoate). The new pathways involve a new class of acyl-CoA esters: 4-phosphoacyl-CoAs formed by the action of a kinase on 4-hydroxyacyl-CoAs.   We found that this pathway exists not only in mammalian cells, but also in microorganisms. Thus these pathways have been conserved through evolution.

    Currently, my work focuses on the metabolism of 4-hydroxynonenal, a toxic metabolite, in perfused hearts of type 2 diabetic rats.  The interaction of 4-hydroxynonenal with the heart is explored using a combination of metabolomics and stable isotope technology.



  . by Guofang Zhang not listed in PubMed (also as PDF List)

  1. Feng M, Zhang G, Zhang Z (1998) A sensitive chemiluminescence method for cinchona alkaloids.  Analytical Letters; 31(14): 2537-48.

  2. Feng M, Zhang G, Zhang Z (1999) FIA determination of pyruvate in serum based on direct chemiluminescence oxidation. Analytical and Bioanalytical Chemistry; 363: 320-22.

  3. Zhang GF, Chen HY (2000) Studies of polyluminol modified electrode and its application electrochemiluminescence analysis with flow system. Analytica Chimica Acta; 419: 25-31.

  4. Zhang GF, Chen HY (2000) Studies of micelle and trace non-polar organic solvent on a new chemiluminescence system and its application to flow injection analysis. Analytica Chimica Acta; 409: 75-81.

  5. Zhang GF, Chen HY (2000) Chemiluminescence studies of the oxidation of ascorbic acid by copper (II) catalysed by halide anions and its application.  Analytical Sciences; 16: 1317-21.

  6. Zhang GF, Chen HY, A sensitive photoinduced chemiluminescence method for the determination of riboflavin with flow injection analysis. Analytical Letters, 2000, 33(15): 3285-3302.

  7. Ye L, Zhang GF, Chen HY  (2000) Studies of the chemiluminescence system-NaIO4-H2O2-Trace cylohexane-polyhydrophenols and its application. Chemical Journal of Chinese Universities, 2000, 21: 59-61.

  8. Zhang GF, Chen HY (2001) Determination of hydrogen peroxide by micelle electrochemiluminescence with flow injection analysis.   Analytical Science Acta (Chinese); (1): 1-5.

  9. Zhou GJ, Zhang GF, Chen HY (2002) Development of integrated chemiluminescence flow sensor for the determination of adrenaline and isoprenaline. Analytica Chimica Acta; 463: 257-63.




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