SELECTED PUBLICATIONS (below)
Dr. Brunengraber served as Chair of the Department of Nutrition until the end of September 2013 - a position he held since he joined the School of Medicine and the former Mt. Sinai Medical Center in 1990. In 2004, Dr. Brunengraber was named the first recipient of the Mt. Sinai Auxiliary Commemorative Chair in Nutrition Research. The professorship was made possible by a grant from the Mt. Sinai Health Care Foundation to commemorate the Mt. Sinai Community Partners, formely the Mt. Sinai Auxiliary. His laboratory (and office), located in the Biomedical Research Building (next to University Hospital of Cleveland), has one of the largest Gas-Chromatography/Mass-Spectrometry facilities in Northeast Ohio. At the present time, his lab is comprised of post-doctoral research associates, undergraduate and graduate students, research assistants, and other essential support staff.
1961 M.S. in Chemistry, Université of Liège (Belgium)
1968 M.D., Université Libre de Bruxelles (Belgium)
1976 Ph.D. in Biochemistry, Université Libre de Bruxelles (Belgium)
In addition to his teaching and mentoring responsibilities at the Case School of Medicine, Dr. Brunengraber is organizes and teaches an annual week-long course in Little Rock, AK on isotopic techniques. The course typically takes place in April. As in past courses, last year's event provided basic introductory and comprehensive information on performing metabolic studies using tracers labeled with radioactive or stable isotopes, in man and in animals.
Synopsis: Metabolic regulation; control of flux through metabolic pathways; design and testing of artificial nutrients; noninvasive probes of liver metabolism; markers of alcoholism; mass spectrometry; metabolomics.
Our Research Investigations in BASIC Nutritional Biochemistry include:
(i) Regulation of the pathways of fatty acid oxidation, ketone body metabolism, citric acid cycle and gluconeogenesis, with an emphasis on metabolomics coupled with stable isotope technology;
(ii) Regulation of malonyl-CoA metabolism in mammalian tissues, emphasing intracellular compartmentation and turnover of malonyl-CoA;
(iii) Exploration of the biochemical basis of new dietary strategies for the treatment of inborn disorders of fatty acid oxidation.
Our Research Investigations in APPLIED the design of new compounds for:
(i) Development of artificial nutrients for the treatment of unborn disorders of metabolism;
(ii) Development and testing of drugs for the prevention of reperfusion injury after myocardial infarction, stroke, and organ transplantation (traps for reducing equivalents and peroxide radicals).
All of these projects make extensive use of animal models (isolated perfused livers and hearts, in vivo preparations) and stable isotope technology GC-MS (AGILENT Gas Chromatography-Mass Spectrometry), LC-MS/MS (Applied Biosystems Liquid Chromatography-Mass Spectrometry) as well as NMR (nuclear magnetic resonance).
The use of Metabolomics has taken an increasing important role in our current research and overall methods of analysis. We also have an ongoing collaboration with Dr. Joanne Kelleher (MIT)
Brunengraber H, Desrochers S, and Landau BR. "Potential of 1,3-butanediol-acetoacetate esters for oral and parenteral nutrition" U.S. Patent 4,997,976. March 5, 1991.
Brunengraber H, Desrochers S, and Landau BR. "Composition for parenteral and oral nutrition" U.S. Patent 5,126,373. June 30, 1992.
Brunengraber H, Desrochers S, and Landau BR. "Use of 1,3-butanediol acetoacetate in parenteral and enteral nutrition" Canadian Patent 1,313,674. February 16, 1993.
Brunengraber H, Bomont C, Quinze K, and Dugas H. "Pyruvate thioester for the prevention of reperfusion injury" U.S. Patent 5,667,962. September 16, 1997.
Brunengraber H, Bomont C, David F, Hallowell P. "Pyruvate compounds and methods for use thereof" U.S. Patent 5,876,916. March 2, 1999.
Brunengraber H, Bomont C, David F, Hallowell P "Pyruvate compounds and methods for use thereof" U.S. Patent 5,968,727. October 19, 1999.
Brunengraber H, Bomont C, David F, Hallowell P, Cooper KD, Kasoumov T. "Medical uses of pyruvate (Dermatologic Applications)" U.S. Patent 6,086,789. July 11, 2000.
OFFICE and LABORATORY
School of Medicine
Biomedical Research Building
Cleveland, OH 44106
216 / 368 6548
216 / 368 6560 FAX