Henri Brunengraber, MD, PhD*

Professor

  • Director: CASE Mouse Metabolic Phenotyping Center (MMPC)
                   One of six such centers in the nation (mmpc.org)

  • Program Director and Training Faculty: Metabolism Training Program (MTP)
*BSTP Trainer
 
RESEARCH INTERESTS


SELECTED PUBLICATIONS (below)
 
all PUBLICATIONS via PubMed

BACKGROUND
Dr. Brunengraber is served as Chair of the Department of Nutrition until the end of September 2013 - a position he held since he joined the School of Medicine and the former Mt. Sinai Medical Center in 1990.  In 2004, Dr. Brunengraber was named the first recipient of the Mt. Sinai Auxiliary Commemorative Chair in Nutrition Research.  The professorship was made possible by a grant from the Mt. Sinai Health Care Foundation to commemorate the Mt. Sinai Community Partners, formely the Mt. Sinai Auxiliary.  His laboratory (and office), located in the Biomedical Research Building (next to University Hospital of Cleveland), has one of the largest Gas-Chromatography/Mass-Spectrometry facilities in Northeast Ohio.  At the present time, his lab is comprised of post-doctoral research associates, undergraduate and graduate students, research assistants, and other essential support staff.


EDUCATION

1961     M.S. in Chemistry, Université of Liège (Belgium)
1968     M.D.,  Université Libre de Bruxelles (Belgium)
1976     Ph.D. in Biochemistry, Université Libre de Bruxelles (Belgium)


TEACHING
In addition to his teaching and mentoring responsibilities at the Case School of Medicine, Dr. Brunengraber is organizes and teaches an annual week-long course in Little Rock, AK on isotopic techniques. The course typically takes place in April.  As in past courses, last year's event provided basic introductory and comprehensive information on performing metabolic studies using tracers labeled with radioactive or stable isotopes, in man and in animals.


RESEARCH INTERESTS
Synopsis: Metabolic regulation; control of flux through metabolic pathways; design and testing of artificial nutrients; noninvasive probes of liver metabolism; markers of alcoholism; mass spectrometry; metabolomics.

Our Research Investigations in BASIC Nutritional Biochemistry include:
(i) Regulation of the pathways of fatty acid oxidation, ketone body metabolism, citric acid cycle and gluconeogenesis, with an emphasis on metabolomics coupled with stable isotope technology;  
(ii) Regulation of malonyl-CoA metabolism in mammalian tissues, emphasing intracellular compartmentation and turnover of malonyl-CoA;  
(iii) Exploration of the biochemical basis of new dietary strategies for the treatment of inborn disorders of fatty acid oxidation.

Our Research Investigations in APPLIED the design of new compounds for:
(i) Development of artificial nutrients for the treatment of unborn disorders of metabolism;
(ii) Development and testing of drugs for the prevention of reperfusion injury after myocardial infarction, stroke, and organ transplantation (traps for reducing equivalents and peroxide radicals).

All of these projects make extensive use of animal models (isolated perfused livers and hearts, in vivo preparations) and stable isotope technology GC-MS (AGILENT Gas Chromatography-Mass Spectrometry), LC-MS/MS (Applied Biosystems Liquid Chromatography-Mass Spectrometry) as well as NMR (nuclear magnetic resonance).


METABOLOMICS
The use of Metabolomics has taken an increasing important role in our current research and overall methods of analysis.   We also have an ongoing collaboration with Dr. Joanne Kelleher (MIT)

SELECTED METABOLOMICS PUBLICATION
Metabolomics, Vol. 2, No. 2, June (© 2006) DOI: 10.1007/s11306-006-0019-1."Metabolomic assays of the concentration and mass isotopomer distribution of gluconeogenic and citric acid cycle intermediates."  FULL TEXT PDF

 

PATENTS
Brunengraber H, Desrochers S, and Landau BR.  "Potential of 1,3-butanediol-acetoacetate esters for oral and parenteral nutrition" U.S. Patent 4,997,976.  March 5, 1991.

Brunengraber H, Desrochers S, and Landau BR.  "Composition for parenteral and oral nutrition"  U.S. Patent 5,126,373.  June 30, 1992.

Brunengraber H, Desrochers S, and Landau BR.   "Use of 1,3-butanediol acetoacetate in parenteral and enteral nutrition" Canadian Patent 1,313,674.  February 16, 1993.

Brunengraber H, Bomont C, Quinze K, and Dugas H. "Pyruvate thioester for the prevention of reperfusion injury" U.S. Patent 5,667,962.  September 16, 1997.

Brunengraber H, Bomont C, David F, Hallowell P.  "Pyruvate compounds and methods for use thereof"  U.S. Patent 5,876,916.  March 2, 1999.

Brunengraber H, Bomont C, David F, Hallowell P  "Pyruvate compounds and methods for use thereof"  U.S. Patent 5,968,727.  October 19, 1999.

Brunengraber H, Bomont C, David F, Hallowell P, Cooper KD, Kasoumov T.   "Medical uses of pyruvate (Dermatologic Applications)"  U.S. Patent  6,086,789.  July 11, 2000.

primary FACULTY

Dr. Brunengraber

CONTACT:

OFFICE and LABORATORY

School of Medicine
Biomedical Research Building
BRB 923
Cleveland, OH 44106

216 / 368 6548
216 / 368 6560  FAX

hxb8@case.edu