Colleen
M. Croniger, PhD
Assistant
Professor
Director - 'CASE' MMPC Metabolic Core
BSTP
Trainer
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office:
CASE - SOM
BRB 925
phone: (216) 368-4967/LAB
X4512
fax: (216) 368-6644
email: colleen.croniger@case.edu
mailing address:
Department of Nutrition
Case Western Reserve University
School of Medicine • WG 48
10900 Euclid Avenue
Cleveland OH 44106-4954
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In January 2008, Dr. CRONIGER was awarded one of the two 2007 Scholarship in Teaching Award of the School of Medicine. Colleen shares this award with Martin Snider from the Department of Biochemistry.
Background
Colleen Croniger received her
Ph.D. in Biology from Case Western Reserve University
in 1990. She then held a Post-Doctoral and Research
Associate position in the Department of Biochemistry
at CWRU.
Dr. Croniger was an Instructor for the Biochemistry
Department before joining the Department of Nutrition
at CWRU as an Assistant Professor. She enjoys teaching
metabolism to both first-year medical students
and graduate students there.
RESEARCH
INTERESTS
My
research is focused on the environmental factors
during the perinatal period that result in obesity
as an adult. This metabolic patterning can affect
many pathways in the liver, muscle, adipose and
pancreatic tissues. Specifically I am studying the molecular changes
in the pancreas of animal models that are either resistant or sensitive
to obesity in response to environmental stresses such as caffeine and
a high-fat diet.
I am also interested in defining genes that are involved
in the patterning of such metabolic pathways. In collaboration with
Dr. Joe Nadeau, I hope to identify genes involved in the metabolic patterning
using mice-congenic strains.
PUBLICATIONS
Carrie A. Millward, Jason D. Heaney, David
S. Sinasac, Eric C. Chu, Ilya R. Bederman,
Danielle A. Gilge, Stephen F. Previs, and
Colleen M. Croniger. Mice
With a Deletion in the Gene for CCAAT/Enhancer-Binding Protein ß Are Protected
Against Diet-Induced Obesity. Diabetes 56:161-167,
2007
Dhawan P, Peng X,
Sutton AL, MacDonald PN, Croniger
CM, Trautwein C, Centrella M, McCarthy TL, Christakos S. Functional
cooperation between CCAAT/enhancer-binding proteins
and the vitamin D receptor in regulation of 25-hydroxyvitamin
D3 24-hydroxylase. Molecular and Cellular
Biology,
January 2005; 25(1): 472-487 (2005).
Resef L, Olswang Y, Cassuto H, Blum B, Croniger
CM, Kalhan SC, Tilghman SM, Hanson RW. Glyceroneogenesis
and the triglyceride/fatty acid cycle. J.
Biol. Chem. Aug. 15; 278(33): 30413-6
(2003).
Parimi PS, Croniger CM, Leahy
P, Kalhan SC and Hanson RW. Effect
of reduced maternal inspired oxygen on hepatic glucose metabolism in the rat
fetus. Pediatric Res., Feb; 53(2): 325-32(2003).
Olswang Y, Cohen H, Papo O, Cassuto H, Croniger
CM, Hakimi P, Tilghman S, Hanson RW and Resef
L. A
mutation in the peroxisome proliferator-activated receptor-?
site of the cytosolic phosphoenopyruvate carboxykinase gene reduces
adipose tissue size and fat content in mice. PNAS; 99:
625-630 (2002).
Croniger CM,
Olswang Y, Reshef L, Kalhan S, Tilghman S and Hanson RW. Phosphoenolpyruvate
Carboxykinase Revisited: II. Control of Pepck-C Gene Expression. BAMBED 30: 353-362 (2002).
Lechner PS, Croniger
CM, Hakimi P, Millward C, Feckter C, Yun
JS, and Hanson RW. The
use of transgenic mice to analyze the role of accessory factor two in the regulation
of phosphoenolpyruvate carboxykinase (GTP) gene transcription during diabetes. J.
Biol. Chem.; 276: 22675-79 (2001).
Croniger CM,
Millward C, Yang J, Kawai Y, Arinze IJ, Liu S, Harada-Shiba M,
Chakravarty K, Friedman JE, Poli V and Hanson RW. Mice
with a deletion in the gene for CCAAT/enhancer-binding protein-ß have
an attenuated response to cAMP and impaired carbohydrate metabolism. J.
Biol. Chem.; 276: 629-638 (2001).
Leahy P, Croniger CM and
Hanson RW. Molecular
and cellular adaptations to carbohydrate and fat intake. Euro.
J. Clinical Nutrition; Suppl 1: S6-S13 (1999).
Arizmendi C, Liu S, Croniger CM,
Poli V and Friedman JE. The
transcription factor CCAAT/Enhancer-binding protein-ß regulates gluconeogenesis
and Phosphoenolpyruvate carboxykinase (GTP) gene transcription during diabetes. J.
Biol. Chem.; 274: 13033-13040 (1999).
Liu S, Croniger
C, Arizmendi C, Harada-Shiba M, Ren J, Poli
V, Hanson RW, Friedman JE. Hypoglycemia
and impaired hepatic glucose production in mice with a deletion
of the C/EBPbeta gene. J.
Clin. Invest.; 103: 207-213 (1999).
Croniger CM, Leahy
P, Resef L and Hanson RW. C/EBP
and the control of phophoenolpyruvate carboxykinase gene transcription
in the liver. J. Biol. Chem.; 273:
31629-31632 (1998).
Christoffels VM, Grange T, Kaestner K, Cole T, Darlington GJ, Croniger
CM and Lamers WH. Glucocorticoid
receptor, C/EBP?, HNF3, and protein kinase A coordinately activate the glucocorticoid
response unit of the carbamoylphosphate synthetase I gene. Mol.
Cell. Biol.; 18: 6305-6315 (1998).
Croniger CM, Trus
M, Lysek-Stupp K, Cohen H, Liu Y, Darlington GJ, Poli V, Hanson
RW and Resef L. Role
of the isoforms of CCAAT/enhancer-binding protein in the initiation
of phosphoenolpyruvate carboxykinase (GTP) gene transcription
at birth. J. Biol. Chem.; 272:
26306-26312 (1997).
Nizielski SE, Lechner PS, Croniger CM,
Wang N, Darlington GL and Hanson RW. Animal
models for studying the genetic basis of metabolic regulation. J.
Nutrition; 126: 2697-2708 (1996).
Levine RJ, Boychuck PL, Croniger CM,
Kazaaz JA, and Rozek CE. Structure
and expression of a muscle-specific gene which is adjacent to the Drosophila
myosin heavy-chain gene and can encode a cytochrome b-related protein. Nucl.
Acids Res.; 17: 6349-6367(1989).
PubMed
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