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BACKGROUND
Dr. Brunengraber received his MD and doctorate in biochemistry from the Université Libre de Bruxelles in Belgium.
He is currently serving as Professor and Chair of
the Department of Nutrition at the Case Western Reserve University
- a position he has held since he joined the School of Medicine and
the former Mt. Sinai Medical Center in 1990.
In 2004, Dr. Brunengraber was named the first recipient of the Mt.
Sinai Auxiliary Commemorative Chair in Nutrition Research. The
professorship was made possible by a grant from the Mt. Sinai Health Care Foundation
to commemorate the Mt. Sinai Community Partners, formely the Mt. Sinai Auxiliary.
His laboratory (and office), which recently relocated to the Biomedical Research
Building (next to University Hospital of Cleveland), houses one of the largest
Gas-Chromatography/Mass-Spectrometry facilities in Northeast Ohio. At
the present time, his lab is comprised of post-doctoral research associates,
undergraduate and graduate students, research assistants, and other essential
support staff. Take
a peek!
1961 M.S. Chemistry, Université of
Liège (Belgium)
1968 M.D., Université Libre
de Bruxelles (Belgium)
1976 Ph.D. Biochemistry, Université Libre
de Bruxelles (Belgium)
PAST POSITIONS
1976-84 Associate Professor - Department of Nutrition - MIT
1984-90 Professor - Department of Nutrition - University of Montréal (Canada)
RESEARCH
INTERESTS
Our laboratory conducts research in BASIC and APPLIED Nutritional
Biochemistry.
OUR BASIC INVESTIGATIONS
INCLUDE:
(i) Regulation of the pathways of fatty acid oxidation, ketone body metabolism,
citric acid cycle and gluconeogenesis, with an emphasis on metabolomics coupled
with stable isotope technology.
(ii) Regulation of malonyl-CoA metabolism in mammalian tissues, emphasing
intracellular compartmentation and turnover of malonyl-CoA.
(iii) Exploration of the biochemical basis of new
dietary strategies for the treatment of inborn
disorders of fatty acid oxidation.
OUR APPLIED INVESTIGATIONS INCLUDE THE DESIGN
OF NEW COMPOUNDS FOR:
(i) Development of artificial nutrients for the treatment of unborn disorders
of metabolism.
(ii) Development and testing of drugs for the prevention of reperfusion injury after myocardial infarction, stroke, and organ transplantation (traps for reducing equivalents and peroxide radicals).
All of the above projects make extensive use of animal models (isolated perfused livers and hearts, in vivo preparations) and stable isotope technology (gas chromatography-mass spectrometry as well as nuclear magnetic resonance)
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