The research
conducted in the CASE Department of Nutrition
emphasizes Nutritional
Biochemistry & Metabolism, Molecular
Nutrition, and Applied Nutrition.
This
research has been conducted in association with several
Cleveland hospitals and other departments within
the School of Medicine. Particular areas of Applied
Nutrition have been developed and performed in field
settings - both the United States and abroad, in
cooperation with multicenter national studies, and
in our own department's various laboratories. These
state-of-the-art laboratories are located in the
School of Medicine and the Veteran Affairs Medical
Center. Facilities in the Clinical Research
Center at University Hospitals Case Medical Center
are also available to our department.
CASE Nutrition department has all general equipment necessary for conducting
studies in nutritional biochemistry and molecular nutrition, including six Agilent
Technologies GC-MS (gas chromatographers -mass spectrometers). They are used
for human and animal investigation with stable isotopes. Facilities for isolated
organ perfusions and a comprehensive organic chemistry laboratory for synthesis
of new nutrients are also available. The department has been equipped for
body composition measures and diet preparation.
Consult the Nutrition Faculty
Directory for specific research projects. To read about each faculty's research
focus at a glance, please read on, below.
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Sports nutrition, the influence
of diet on insulin resistance and the interrelationship of diet
and liver cirrhosis.
Regulation of carbohydrate
and fat metabolism investigated with stable isotopes via Mass
Spectrometry-Gas Chromatography.
Nutrition and cardiovascular
diseases; nutrient-drug interactions; metabolic pharmacology; genetic
obesity; lipids in cell signaling.
Molecular mechanisms regulation
of gene expression during stress.
Design and synthesis of labeled
precursors and intermediates for studies/artificial
nutrients. Investigation
of anaplerosis from propionyl-CoA precursors.
Sports nutrition; eating
disorders; weight management and nutrition for cardiovascular health.
Mitochondrial fatty acid
oxidation and the regulation of pathway by malonyl-CoA.
Assessment of nutritional
status and trace mineral metabolism during pregnancy. The
neonatal patient.
Nutrient regulation of gene
expression.
Effects of environmental
factors such as diet and drugs on cellular signal transduction mechanism.
Nutritional anthropology;
maternal and child nutrition; public health nutrition; child growth
and schistosomiasis.
Application of stable isotopes
for measuring carbohydrate, fat and protein metabolism.
Coordinator for the Dietetic Internship/Master's Degree
Program.
Interplay between mineral
nutrition and the etiology and severity of chronic disease, especially
related to iron status.
Fatty acid metabolism; beta-oxidation;
unsaturated fatty acids; stable isotope tracers.
Molecular basis of insulin
binding and receptor activation. |
