Publications

 


Publications in 2008

Collard F, Zhang J, Nemet I, Qanungo KR, Monnier VM, Yee VC.
Crystal Structure of the Deglycating Enzyme Fructosamine Oxidase (Amadoriase II). J Biol Chem. 2008; 283: 27007-16.

Bucciarelli LG, Ananthakrishnan R, Hwang YC, Kaneko M, Song F, Sell DR, Strauch C, Monnier VM, Yan SF, Schmidt AM, Ramasamy R.
RAGE and modulation of ischemic injury in the diabetic myocardium. Diabetes. 2008 57:1941-51.

Dai Z, Wang B, Sun G, Fan X, Anderson VE, Monnier VM.
Identification of glucose-derived cross-linking sites in ribonuclease A. J Proteome Res. 2008 7:2756-68.

Fan X, Monnier VM.
Nucleophilic compounds decrease crystallin ascorbylation in the hSVCT2 mouse model of lenticular aging. Invest Ophthalmol Vis Sci. 2008

Sell DR, Strauch CM, Shen W, Monnier VM.
Aging, diabetes, and renal failure catalyze the oxidation of lysyl residues to 2-aminoadipic acid in human skin collagen: evidence for metal-catalyzed oxidation mediated by alpha-dicarbonyls. Ann N Y Acad Sci. 2008 126:205-9.

Fan X, Monnier VM.
Vitamin C-mediated Maillard reaction in the lens probed in a transgenic-mouse model. Ann N Y Acad Sci. 2008 1126:194-200.

Monnier VM, Sell DR, Dai Z, Nemet I, Collard F, Zhang J.
The role of the amadori product in the complications of diabetes. Ann N Y Acad Sci. 2008 1126:81-8.

Ozdemir AM, Hopfer U, Rosca MV, Fan XJ, Monnier VM, Weiss MF.
Effects of advanced glycation end product modification on proximal tubule epithelial cell processing of albumin. Am J Nephrol. 2008 28:14-24.

Publications in 2007

Monnier VM.
Dietary advanced lipoxidation products as risk factors for human health--a call for data. Mol Nutr Food Res. 2007 51:1091-3.

Dai Z, Nemet I, Shen W, Monnier VM.
Isolation, purification and characterization of histidino-threosidine, a novel Maillard reaction protein crosslink from threose, lysine and histidine. Arch Biochem Biophys. 2007 463:78-88.

Sell DR, Strauch CM, Shen W, Monnier VM.
2-aminoadipic acid is a marker of protein carbonyl oxidation in the aging human skin: effects of diabetes, renal failure and sepsis. Biochem J. 2007 404:269-77.

Pageon H, Bakala H, Monnier VM, Asselineau D.
Collagen glycation triggers the formation of aged skin in vitro. Eur J Dermatol. 2007 17:12-20.

Publications in 2006

Obrenovich ME, Fan X, Satake M, Jarvis SM, Reneker L, Reddan JR, Monnier VM.
Relative suppression of the sodium-dependent Vitamin C transport in mouse versus human lens epithelial cells. Mol Cell Biochem. 2006 293:53-62.

Fan X, Reneker LW, Obrenovich ME, Strauch C, Cheng R, Jarvis SM, Ortwerth BJ, Monnier VM.
Vitamin C mediates chemical aging of lens crystallins by the Maillard reaction in a humanized mouse model. Proc Natl Acad Sci U S A. 2006 10316912-7.

Monnier VM.
The fructosamine 3-kinase knockout mouse: a tool for testing the glycation hypothesis of intracellular protein damage in diabetes and aging. Biochem J. 2006 399:e11-3.

Monnier VM, Sell DR.
Prevention and repair of protein damage by the Maillard reaction in vivo.
Rejuvenation Res. 2006 9:264-73.

Publications in 2005

Monnier VM.
Bacterial enzymes that can deglycate glucose- and fructose-modified lysine.
Biochem J. 2005 392(Pt 2):e1-3.

Genuth S, Sun W, Cleary P, Sell DR, Dahms W, Malone J, Sivitz W, Monnier VM; DCCT Skin Collagen Ancillary Study Group.
Glycation and carboxymethyllysine levels in skin collagen predict the risk of future 10-year progression of diabetic retinopathy and nephropathy in the diabetes control and complications trial and epidemiology of diabetes interventions and complications participants with type 1 diabetes. Diabetes. 2005 11:3103-11.

Rosca MG, Mustata TG, Kinter MT, Ozdemir AM, Kern TS, Szweda LI, Brownlee M, Monnier VM, Weiss MF.
Glycation of mitochondrial proteins from diabetic rat kidney is associated with excess superoxide formation. Am J Physiol Renal Physiol. 2005 289:F420-30.

Ozdemir AM, Hopfer U, Erhard P, Monnier VM, Weiss MF.
Processing advanced glycation end product-modified albumin by the renal proximal tubule and the early pathogenesis of diabetic nephropathy. Ann N Y Acad Sci. 2005 1043:625-36.

Monnier VM, Sell DR, Genuth S.
Glycation products as markers and predictors of the progression of diabetic complications. Ann N Y Acad Sci. 2005 1043:567-81.

Monnier VM, Mustata GT, Biemel KL, Reihl O, Lederer MO, Zhenyu D, Sell DR.
Abstract
Cross-linking of the extracellular matrix by the maillard reaction in aging and diabetes: an update on "a puzzle nearing resolution". Ann N Y Acad Sci. 2005 1043:533-44.

Sell DR, Monnier VM.
Ornithine is a novel amino acid and a marker of arginine damage by oxoaldehydes in senescent proteins. Ann N Y Acad Sci. 2005 1043:118-28.

Sell DR, Biemel KM, Reihl O, Lederer MO, Strauch CM, Monnier VM.
Glucosepane is a major protein cross-link of the senescent human extracellular matrix. Relationship with diabetes. J Biol Chem. 2005 280:12310-5.

Mustata GT, Rosca M, Biemel KM, Reihl O, Smith MA, Viswanathan A, Strauch C, Du Y, Tang J, Kern TS, Lederer MO, Brownlee M, Weiss MF, Monnier VM.
Paradoxical effects of green tea (Camellia sinensis) and antioxidant vitamins in diabetic rats: improved retinopathy and renal mitochondrial defects but deterioration of collagen matrix glycoxidation and cross-linking. Diabetes. 2005 54:517-26.

Obrenovich ME, Monnier VM.
Apoptotic killing of fibroblasts by matrix-bound advanced glycation endproducts.
Sci Aging Knowledge Environ. 2005 2005:pe3.

Publications in 2004

Sell DR, Monnier VM.
Conversion of arginine into ornithine by advanced glycation in senescent human collagen and lens crystallins. J Biol Chem. 2004 279:54173-84.

Obrenovich ME, Monnier VM.
Glycation stimulates amyloid formation. Sci Aging Knowledge Environ. 2004 2004:pe3.

Fernando MR, Satake M, Monnier VM, Lou MF.
Thioltranferase mediated ascorbate recycling in human lens epithelial cells.
Invest Ophthalmol Vis Sci. 2004 45:230-7.

Publications in 2003

Monnier VM, Wu X.
Enzymatic deglycation with amadoriase enzymes from Aspergillus sp. as a potential strategy against the complications of diabetes and aging. Biochem Soc Trans. 2003 31:1349-53.

Wu X, Monnier VM.
Enzymatic deglycation of proteins. Arch Biochem Biophys. 2003 419:16-24.

Monnier VM.
Intervention against the Maillard reaction in vivo. Arch Biochem Biophys. 2003 419:1-15.

Rutter K, Sell DR, Fraser N, Obrenovich M, Zito M, Starke-Reed P, Monnier VM.
Green tea extract suppresses the age-related increase in collagen crosslinking and fluorescent products in C57BL/6 mice. Int J Vitam Nutr Res. 2003 73:453-60.

Usta MF, Bivalacqua TJ, Yang DY, Ramanitharan A, Sell DR, Viswanathan A, Monnier VM, Hellstrom WJ.
The protective effect of aminoguanidine on erectile function in streptozotocin diabetic rats. J Urol. 2003 170:1437-42.

Sell DR, Lane MA, Obrenovich ME, Mattison JA, Handy A, Ingram DK, Cutler RG, Roth GS, Monnier VM.
The effect of caloric restriction on glycation and glycoxidation in skin collagen of nonhuman primates. J Gerontol A Biol Sci Med Sci. 2003 58:508-16.

Nishikawa Y, Dmochowska B, Madaj J, Xue J, Guo Z, Satake M, Reddy DV, Rinaldi PL, Monnier VM.
Vitamin C metabolomic mapping in experimental diabetes with 6-deoxy-6-fluoro-ascorbic acid and high resolution 19F-nuclear magnetic resonance spectroscopy.
Metabolism. 2003 52:760-70.

Satake M, Dmochowska B, Nishikawa Y, Madaj J, Xue J, Guo Z, Reddy DV, Rinaldi PL, Monnier VM.
Vitamin C metabolomic mapping in the lens with 6-deoxy-6-fluoro-ascorbic acid and high-resolution 19F-NMR spectroscopy. Invest Ophthalmol Vis Sci. 2003 44:2047-58.

Obrenovich ME, Monnier VM.
Vitamin B1 blocks damage caused by hyperglycemia. Sci Aging Knowledge Environ. 2003 12:PE6.

Tessier FJ, Monnier VM, Sayre LM, Kornfield JA.
Triosidines: novel Maillard reaction products and cross-links from the reaction of triose sugars with lysine and arginine residues. Biochem J. 2003 369:705-19.

Fan X, Subramaniam R, Weiss MF, Monnier VM.
Methylglyoxal-bovine serum albumin stimulates tumor necrosis factor alpha secretion in RAW 264.7 cells through activation of mitogen-activating protein kinase, nuclear factor kappaB and intracellular reactive oxygen species formation. Arch Biochem Biophys. 2003 409:274-86.

Publications in 2002

Monnier VM, Obrenovich ME.
Wake up and smell the maillard reaction. Sci Aging Knowledge Environ. 2002 50:pe21.

Rosca MG, Monnier VM, Szweda LI, Weiss MF.
Alterations in renal mitochondrial respiration in response to the reactive oxoaldehyde methylglyoxal. Am J Physiol Renal Physiol. 2002 283:F52-9.

Wu X, Chen SG, Petrash JM, Monnier VM.
Alteration of substrate selectivity through mutation of two arginine residues in the binding site of amadoriase II from Aspergillus sp. Biochemistry. 2002 41:4453-8.

Subramaniam R, Fan XJ, Scivittaro V, Yang J, Ha CE, Petersen CE, Surewicz WK, Bhagavan NV, Weiss MF, Monnier VM.
Cellular oxidant stress and advanced glycation endproducts of albumin: caveats of the dichlorofluorescein assay. Arch Biochem Biophys. 2002 400:15-25.

Publications in 2001

Wu X, Palfey BA, Mossine VV, Monnier VM.
Kinetic studies, mechanism, and substrate specificity of amadoriase I from Aspergillus sp. Biochemistry. 2001 40:12886-95.

Sell DR, Nelson JF, Monnier VM.
Effect of chronic aminoguanidine treatment on age-related glycation, glycoxidation, and collagen cross-linking in the Fischer 344 rat. J Gerontol A Biol Sci Med Sci. 2001 56:B405-11.

Monnier VM.
Transition metals redox: reviving an old plot for diabetic vascular disease. J Clin Invest. 2001 107:799-801.

Publications in 2000

Madaj J, Nishikawa Y, Reddy VP, Rinaldi P, Kurata T, Monnier VM.
6-Deoxy-6-fluoro-L-ascorbic acid: crystal structure and oxidative degradation.
Carbohydr Res. 2000 329:477-85.

Weiss MF, Erhard P, Kader-Attia FA, Wu YC, Deoreo PB, Araki A, Glomb MA, Monnier VM.
Mechanisms for the formation of glycoxidation products in end-stage renal disease.
Kidney Int. 2000 57:2571-85.

Saxena P, Saxena AK, Cui XL, Obrenovich M, Gudipaty K, Monnier VM.
Free Full Text
Transition metal-catalyzed oxidation of ascorbate in human cataract extracts: possible role of advanced glycation end products. Invest Ophthalmol Vis Sci. 2000 41:1473-81.

Frank A, Sell DR, Danielsson R, Fogarty JF, Monnier VM.
A syndrome of molybdenosis, copper deficiency, and type 2 diabetes in the moose population of south-west Sweden. Sci Total Environ. 2000 249:123-31.

Wu X, Takahashi M, Chen SG, Monnier VM.
Cloning of amadoriase I isoenzyme from Aspergillus sp.: evidence of FAD covalently linked to Cys342. Biochemistry. 2000 39:1515-21.

Sell DR, Kleinman NR, Monnier VM.
Longitudinal determination of skin collagen glycation and glycoxidation rates predicts early death in C57BL/6NNIA mice. FASEB J. 2000 14:145-56.

Dominguez JH, Tang N, Xu W, Evan AP, Siakotos AN, Agarwal R, Walsh J, Deeg M, Pratt JH, March KL, Monnier VM, Weiss MF, Baynes JW, Peterson R.
Studies of renal injury III: lipid-induced nephropathy in type II diabetes.
Kidney Int. 2000 57:92-104.

Publications in 1999

Tessier F, Obrenovich M, Monnier VM.
Structure and mechanism of formation of human lens fluorophore LM-1. Relationship to vesperlysine A and the advanced Maillard reaction in aging, diabetes, and cataractogenesis. J Biol Chem. 1999 274:20796-804.

Saxena AK, Saxena P, Wu X, Obrenovich M, Weiss MF, Monnier VM.
Protein aging by carboxymethylation of lysines generates sites for divalent metal and redox active copper binding: relevance to diseases of glycoxidative stress. Biochem Biophys Res Commun. 1999 260:332-8.

Monnier VM, Bautista O, Kenny D, Sell DR, Fogarty J, Dahms W, Cleary PA, Lachin J, Genuth S.
Skin collagen glycation, glycoxidation, and crosslinking are lower in subjects with long-term intensive versus conventional therapy of type 1 diabetes: relevance of glycated collagen products versus HbA1c as markers of diabetic complications. DCCT Skin Collagen Ancillary Study Group. Diabetes Control and Complications Trial.
Diabetes. 1999 48:870-80.

Weiss MF, Saxena AK, Monnier VM.
Pharmacological modulation of AGEs: a unique role for redox-active metal ions.
Perit Dial Int. 1999 2:S62-7.

Publications in 1998

Sell DR, Primc M, Schafer IA, Kovach M, Weiss MA, Monnier VM.
Cell-associated pentosidine as a marker of aging in human diploid cells in vitro and in vivo. Mech Ageing Dev. 1998 105:221-40.

Publications in 1997

Horie K, Miyata T, Maeda K, Miyata S, Sugiyama S, Sakai H, van Ypersole de Strihou C, Monnier VM, Witztum JL, Kurokawa K.
Immunohistochemical colocalization of glycoxidation products and lipid peroxidation products in diabetic renal glomerular lesions. Implication for glycoxidative stress in the pathogenesis of diabetic nephropathy. J Clin Invest. 1997 100:2995-3004.

Sell DR, Monnier VM.
Age-related association of tail tendon break time with tissue pentosidine in DBA/2 vs C57BL/6 mice: the effect of dietary restriction. J Gerontol A Biol Sci Med Sci. 1997 52:B277-84.

Castellani RJ, Perry G, Harris PL, Monnier VM, Cohen ML, Smith MA.
Advanced glycation modification of Rosenthal fibers in patients with Alexander disease.
Neurosci Lett. 1997 231:79-82.

Takahashi M, Pischetsrieder M, Monnier VM.
Molecular cloning and expression of amadoriase isoenzyme (fructosyl amine:oxygen oxidoreductase, EC 1.5.3) from Aspergillus fumigatus. J Biol Chem. 1997 272:12505-7.

Salomon RG, Subbanagounder G, O'Neil J, Kaur K, Smith MA, Hoff HF, Perry G, Monnier VM.
Levuglandin E2-protein adducts in human plasma and vasculature. Chem Res Toxicol. 1997 10:536-45.

Takahashi M, Pischetsrieder M, Monnier VM.
Isolation, purification, and characterization of amadoriase isoenzymes (fructosyl amine-oxygen oxidoreductase EC 1.5.3) from Aspergillus sp. J Biol Chem. 1997 272:3437-43.

Publications in 1996

Saxena AK, Saxena P, Monnier VM.
Purification and characterization of a membrane-bound deglycating enzyme (1-deoxyfructosyl alkyl amino acid oxidase, EC 1.5.3) from a Pseudomonas sp. soil strain.
J Biol Chem. 1996 271:32803-9.

Saxena P, Saxena AK, Monnier VM.
High galactose levels in vitro and in vivo impair ascorbate regeneration and increase ascorbate-mediated glycation in cultured rat lens. Exp Eye Res. 1996 63:535-45.

Monnier VM, Glomb M, Elgawish A, Sell DR.
The mechanism of collagen cross-linking in diabetes: a puzzle nearing resolution.
Diabetes. 1996 3:S67-72.

Elgawish A, Glomb M, Friedlander M, Monnier VM.
Involvement of hydrogen peroxide in collagen cross-linking by high glucose in vitro and in vivo. J Biol Chem. 1996 271:12964-71.

Nagaraj RH, Kern TS, Sell DR, Fogarty J, Engerman RL, Monnier VM.
Evidence of a glycemic threshold for the formation of pentosidine in diabetic dog lens but not in collagen. Diabetes. 1996 45:587-94.

Smith MA, Sayre LM, Monnier VM, Perry G.
Oxidative posttranslational modifications in Alzheimer disease. A possible pathogenic role in the formation of senile plaques and neurofibrillary tangles.
Mol Chem Neuropathol. 1996 28:41-8.

Monnier VM.
Aminoguanidine and diabetic neuropathy. Eur J Endocrinol. 1996 134:398-400.

Miyata T, Taneda S, Kawai R, Ueda Y, Horiuchi S, Hara M, Maeda K, Monnier VM.
Identification of pentosidine as a native structure for advanced glycation end products in beta-2-microglobulin-containing amyloid fibrils in patients with dialysis-related amyloidosis. Proc Natl Acad Sci U S A. 1996 93:2353-8.

Friedlander MA, Wu YC, Elgawish A, Monnier VM.
Early and advanced glycosylation end products. Kinetics of formation and clearance in peritoneal dialysis. J Clin Invest. 1996 97:728-35.

Miyata T, Iida Y, Ueda Y, Shinzato T, Seo H, Monnier VM, Maeda K, Wada Y.
Monocyte/macrophage response to beta 2-microglobulin modified with advanced glycation end products. Kidney Int. 1996 49:538-50.

Nagaraj RH, Portero-Otin M, Monnier VM.
Pyrraline ether crosslinks as a basis for protein crosslinking by the advanced Maillard reaction in aging and diabetes. Arch Biochem Biophys. 1996 325:152-8.

Sell DR, Lane MA, Johnson WA, Masoro EJ, Mock OB, Reiser KM, Fogarty JF, Cutler RG, Ingram DK, Roth GS, Monnier VM.
Longevity and the genetic determination of collagen glycoxidation kinetics in mammalian senescence. Proc Natl Acad Sci U S A. 1996 93:485-90.

Monnier VM, Nagaraj RH, Portero-Otin M, Glomb M, Elgawish AH, Sell DR, Friedlander MA.
Structure of advanced Maillard reaction products and their pathological role.
Nephrol Dial Transplant. 1996; 5:20-6.

Publications in 1995

Nagaraj RH, Monnier VM.
Protein modification by the degradation products of ascorbate: formation of a novel pyrrole from the Maillard reaction of L-threose with proteins. Biochim Biophys Acta. 1995 1253:75-84.

Smith MA, Monnier VM, Sayre LM, Perry G.
Amyloidosis, advanced glycation end products and Alzheimer disease. Neuroreport. 1995 6:1595-6.

Glomb MA, Monnier VM.
Mechanism of protein modification by glyoxal and glycolaldehyde, reactive intermediates of the Maillard reaction. J Biol Chem. 1995 270:10017-26.

Smith MA, Sayre LM, Monnier VM, Perry G.
Radical AGEing in Alzheimer's disease. Trends Neurosci. 1995 18:172-6.

Smith MA, Sayre LM, Vitek MP, Monnier VM, Perry G.
Early AGEing and Alzheimer's. Nature. 1995 374:316.

Friedlander MA, Wu YC, Schulak JA, Monnier VM, Hricik DE.
Influence of dialysis modality on plasma and tissue concentrations of pentosidine in patients with end-stage renal disease. Am J Kidney Dis. 1995 25:445-51.

Portero-Otin M, Nagaraj RH, Monnier VM.
Chromatographic evidence for pyrraline formation during protein glycation in vitro and in vivo. Biochim Biophys Acta. 1995 1247:74-80.

Gerhardinger C, Marion MS, Rovner A, Glomb M, Monnier VM.
Novel degradation pathway of glycated amino acids into free fructosamine by a Pseudomonas sp. soil strain extract. J Biol Chem. 1995 270:218-24.

DiFranco E, Subbanagounder G, Kim S, Murthi K, Taneda S, Monnier VM, Salomon RG.
Formation and stability of pyrrole adducts in the reaction of levuglandin E2 with proteins.
Chem Res Toxicol. 1995 8:61-7.

Jiaan DB, Seftel AD, Fogarty J, Hampel N, Cruz W, Pomerantz J, Zuik M, Monnier VM.
Age-related increase in an advanced glycation end product in penile tissue. World J Urol. 199513:369-75.

Publications in 1994

Smith MA, Richey PL, Taneda S, Kutty RK, Sayre LM, Monnier VM, Perry G.
Advanced Maillard reaction end products, free radicals, and protein oxidation in Alzheimer's disease. Ann N Y Acad Sci. 1994 738:447-54.

Gerhardinger C, Taneda S, Marion MS, Monnier VM.
Isolation, purification, and characterization of an Amadori product binding protein from a Pseudomonas sp. soil strain. J Biol Chem. 1994 269:27297-302.

Taneda S, Monnier VM.
ELISA of pentosidine, an advanced glycation end product, in biological specimens.
Clin Chem. 1994 40:1766-73. Erratum in: Clin Chem 1995 41:770.

Smith MA, Taneda S, Richey PL, Miyata S, Yan SD, Stern D, Sayre LM, Monnier VM, Perry G.
Advanced Maillard reaction end products are associated with Alzheimer disease pathology. Proc Natl Acad Sci U S A. 1994 91:5710-4. Erratum in: Proc Natl Acad Sci U S A 1995 92:2016.

Nagaraj RH, Prabhakaram M, Ortwerth BJ, Monnier VM.
Suppression of pentosidine formation in galactosemic rat lens by an inhibitor of aldose reductase. Diabetes. 1994 43:580-6.

Monnier VM, Sell DR, Nagaraj RH.
The role of glucose in the pathogenesis of diabetes complications Journ Annu Diabetol Hotel Dieu. 1994:61-70.

Publications in 1993

Differential effects of type 2 (non-insulin-dependent) diabetes mellitus on pentosidine formation in skin and glomerular basement membrane. Diabetologia. 1993 36:936-41.

Hricik DE, Schulak JA, Sell DR, Fogarty JF, Monnier VM.
Effects of kidney or kidney-pancreas transplantation on plasma pentosidine. Kidney Int. 1993 43:398-403.

Monnier VM, Miyata S, Nagaraj RH, Sell DR.
Relevance of the early and advanced Maillard reaction in diabetic neuropathy.
Diabet Med. 1993;10 Suppl 2:103S-106S.

Publications in 1992

Monnier VM, Sell DR, Nagaraj RH, Miyata S, Grandhee S, Odetti P, Ibrahim SA.
Maillard reaction-mediated molecular damage to extracellular matrix and other tissue proteins in diabetes, aging, and uremia. Diabetes. 1992 41 Suppl 2:36-41.

Sell DR, Lapolla A, Odetti P, Fogarty J, Monnier VM.
Pentosidine formation in skin correlates with severity of complications in individuals with long-standing IDDM. Diabetes. 1992 41:1286-92.

Nagaraj RH, Monnier VM.
Isolation and characterization of a blue fluorophore from human eye lens crystallins: in vitro formation from Maillard reaction with ascorbate and ribose. Biochim Biophys Acta. 1992 1116:34-42.
Odetti P, Fogarty J, Sell DR, Monnier VM.
Chromatographic quantitation of plasma and erythrocyte pentosidine in diabetic and uremic subjects. Diabetes. 1992 41:153-9.

Publications in 1991

Sell DR, Nagaraj RH, Grandhee SK, Odetti P, Lapolla A, Fogarty J, Monnier VM.
Pentosidine: a molecular marker for the cumulative damage to proteins in diabetes, aging, and uremia. Diabetes Metab Rev. 1991 7:239-51.

Nagaraj RH, Sell DR, Prabhakaram M, Ortwerth BJ, Monnier VM.
High correlation between pentosidine protein crosslinks and pigmentation implicates ascorbate oxidation in human lens senescence and cataractogenesis. Proc Natl Acad Sci U S A. 1991 88:10257-61.

Richard S, Tamas C, Sell DR, Monnier VM.
Tissue-specific effects of aldose reductase inhibition on fluorescence and cross-linking of extracellular matrix in chronic galactosemia. Relationship to pentosidine cross-links. Diabetes. 1991 40:1049-56.

Grandhee SK, Monnier VM.
Mechanism of formation of the Maillard protein cross-link pentosidine. Glucose, fructose, and ascorbate as pentosidine precursors. J Biol Chem. 1991 266:11649-53.

Monnier VM, Sell DR, Nagaraj RH, Miyata S.
Mechanisms of protection against damage mediated by the Maillard reaction in aging.
Gerontology. 1991 37:152-65.