Which AGEs can be measured by GC/MS or by LC/MS or HPLC/fluorescence?

By GC/MS acid stable AGEs can be measured such as CML, CEL and fructoselysine (as furosine) while by the LC/MS system, acid unstable compounds (including acid stable) can be quantified. Pentosidine and argpyrimidine can be determined by an HPLC system with fluorescence detector.

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Advanced glycation and oxidation products

Advanced glycation end products (AGEs) are formed during nonenzymatic reactions of reducing sugars and other reactive carbonyls with proteins.

Together with glycation, proteins in vivo are also modified by reactive oxygen species (ROS). These reactions are also accelerated in diabetes and end stage renal disease.

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Vincent M. Monnier

Department of Pathology
Case Western Reserve University
2103 Cornell Road
Cleveland, Ohio 44106-7288

vmm3@cwru.edu

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Which of the following AGEs and/or oxidation products do you want to measure?
(Note: It is recommended that you discuss your project with us prior to ordering)

Glycooxidation Panel
CML, CEL, Fructosyl-lysine (furosine), pentosidine

Oxidation Panel
CML, allysine (measured as 6-OH-norleucine), 2-aminoadipic acid, methionine sulfoxide

Total AGE Panel
Glycation and Oxidation Panel (CML, CEL, FL, Glucosepane, MG-H1, G-H1, 2-aminoadipic acid, allysine (measured as 6-OH-norleucine), methionine sulfoxide, pentosidine)

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Aorta

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