By GC/MS acid stable AGEs can be measured such as CML, CEL and fructoselysine (as furosine) while by the LC/MS system, acid unstable compounds (including acid stable) can be quantified. Pentosidine and argpyrimidine can be determined by an HPLC system with fluorescence detector.Learn more
Advanced glycation end products (AGEs) are formed during nonenzymatic reactions of reducing sugars and other reactive carbonyls with proteins.
Together with glycation, proteins in vivo are also modified by reactive oxygen species (ROS). These reactions are also accelerated in diabetes and end stage renal disease.
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