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TEE is equal to the sum of basal metabolic metabolic, thermic effect of eating and physical activity. Following a single bolus injection of 2H and 18O-labeled water one can determine TEE via the elimination of 2H and 18O from body water. This test requires serial measurements of the labeling of body water over approximately 1 week, which necessitates the collection of blood or urine samples.
Note: This test does not require catheterized mice, nor does it require that mice be shipped to the MMPC. The isotopes are non-radioactive and no special safety precautions are required, the tracers will be shipped from the MMPC to the investigator. Investigators will be instructed on how to administer the isotopes, collect samples and then ship them back to the MMPC.
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