I am studying in the laboratory of Dr. Liem Nguyen to identify and characterize mycobacterial factors required for intrinsic drug resistance and their role in virulence of Mycobacterium tuberculosis.
Our lab is interested in the triangle of interactions between pathogenic mycobacteria-host responses and the antibiotics used to treat tuberculosis.
Kerstin A. Wolff, Marissa B. Sherman & Liem Nguyen (2011). Potentiation of Available Antibiotics by Targeting Resistance - An Emerging Trend in Tuberculosis Drug Development. In Potentiation of Available Antibiotics by Targeting Resistance: An Emerging Trend in Tuberculosis Drug Development (Rundfeldt, C., ed.), InTech. Epub 2011 Dec 07. [elink]
Nguyen HT, Wolff KA, Cartabuke RH, Ogwang S & Nguyen L. (2010) A lipoprotein modulates activity of the MtrAB two-component system to provide intrinsic multidrug resistance, cytokinetic control and cell wall homeostasis in Mycobacterium. Mol Microbiol 76, 348-364. [PubMed]
Kerstin A. Wolff, Hoa T. Nguyen, Richard H. Cartabuke, Ajay Singh, Sam Ogwang, and Liem Nguyen. Protein kinase G is required for Intrinsic Antibiotic Resistance in Mycobacteria. Antimicrob Agents Chemother. 2009 Aug; 53(8):3515-9. Epub 2009 Jun 15. [PubMed]