CASE.EDU:    HOME | DIRECTORIES | SEARCH
Case Western Reserve University

MOLECULAR BIOLOGY AND MICROBIOLOGY

 

Rietsch lab receives funding to study type III effectors critical to the development of corneal disease

 

The Rietsch lab received funding from the National Eye Institute to study the role of specific type III secreted effectors in keratitis caused by the bacterial pathogen Pseudomonas aeruginosa. Type III secretion involves a needle-like secretion apparatus that allows P. aeruginosa to directly inject effector proteins into targeted host cells. The effectors allow the bacterium to circumvent the host immune response and are critical for the development of corneal disease. The role of individual effector proteins in disease will be studied in collaboration with Dr. Eric Pearlman’s group in the Visual Sciences Research Center.