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Case Western Reserve University

MOLECULAR BIOLOGY
and MICROBIOLOGY

 
 
       
 

 

Robert H. Silverman


Professor

Antiviral and Tumor Suppressor Roles of Interferon Regulated Proteins

Office Phone: 216-445-9650
Office Fax: 216.445.6269
email: silverr@ccf.org


     
 

Dr. Silverman has investigated molecular pathways of antiviral innate immunity for the past 34 years.  His studies are mainly focused on the 2’,5’-oligoadenylate (2-5A) synthetase (OAS)/RNase L system, a classical interferon-regulated, innate immune pathway that rapidly responds to PAMPs to produce a broadly active antiviral response. In prior studies, his lab purified and cloned RNase L, generated RNase L-deficient mice, established antiviral and apoptotic activities of RNase L in vivo, and determined that RNase L activation induces autophagy and initiates transcriptional signaling pathways.  In current studies, he is investigating control of viral pathogenesis by regulating 2-5A turnover.  His goal is to continue probing fundamental events and biologic endpoints that impact on viral replication cycles and cancer biology. 

Silverman Lab Webpage
www.lerner.ccf.org/cancerbio/silverman/

Selected Publications

Zhou, A., Hassel, B.A., and Silverman, R.H. Expression cloning of 2-5A-dependent RNase-a uniquely regulated mediator of interferon action. Cell, 72, 753-765, 1993.

Der, S., Zhou, A., Williams, B.R.G., and Silverman, R.H.Identification of Genes Differentially Regulated by IFN-α β or γ or Using Oligonucleotide Arrays. Proc. Natl. Acad. Sci. U.S.A 95,15623-15628, 1998.

Malathi, K., Dong, B., Gale, M., and Silverman, R.H. Small Self RNA Generated by RNase L Amplifies Antiviral Innate Immunity. Nature, 448: 816-819, 2007. [PubMed]

Chakrabarti, A., Ghosh, P.K., Banerjee, S., Gaughan, C., and Silverman, R.H. RNase L triggers autophagy in response to viral infections. J. Virol. 86: 11311-21, 2012. [PubMed]

Zhang, R., Jha, B.K., Ogden, K., Dong, B., Zhao, L., Elliot, R., Patton, J.T., Silverman, R.H.* and Weiss, S.R.* Homologous 2',5'-phosphodiesterases from disparate RNA viruses antagonize antiviral innate immunity. Proc. Natl. Acad. Sci., Epub, 2013. [*Co-corresponding authors]. [PubMed]

Complete list of Publications