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Research:
Adhesion molecules and their regulation are integral to our understanding of the development of the visual system. We study the adhesion molecule PTPµ, a receptor tyrosine phosphatase, in the chick visual system. Neurons from the retina contact with and respond to various adhesion molecules by extending long processes called neurites.
Our lab has shown that PTPµ can promote neurite outgrowth. Currently we are looking at various promoters of neurite outgrowth and the pathways that influence this behavior.
Publications:
Mosig RA, Dowling O, Difeo A, Ramirez MC, Parker IC, Abe E, Diouri J, Aqeel AA, Wylie JD, Oblander SA, Madri J, Bianco P, Apte SS, Zaidi M, Doty SB, Majeska RJ, Schaffler MB, Martignetti JA. Loss of MMP-2 disrupts skeletal and craniofacial development, and results in decreased bone mineralization, joint erosion, and defects in osteoblast and osteoclast growth. Hum Mol Genet. 2007 Mar 30; [PubMed]
Oblander SA, Ensslen-Craig SE, Longo FM, Brady-Kalnay SM. E-cadherin promotes retinal ganglion cell neurite outgrowth in a protein tyrosine phosphatase-mu-dependent manner. Mol Cell Neurosci. 2007 Mar;34(3):481-92. Epub 2007 Feb 2. [PubMed]
Galvez BG, Genis-Martin L, Matias-Roman S, Oblander SA, Tryggvason K, Apte SS, Arroyo AG. (2005) Membrane type 1-matrix metalloproteinase is regulated by chemokines monocyte-chemoattractant protein-1/ccl2 and interleukin-8/CXCL8 in endothelial cells during angiogenesis. J Biol Chem. Jan 14;280(2):1292-8. [PubMed]
Oblander SA, Zhou Z, Gonzales BG, Starcher B, Shannon JM, Durbeej M, Tryggvason K, Apte SS. (2005) Distinctive functions of membrane type 1 matrix-metalloprotease (MT1-MMP or MMP-14) in lung and submandibular gland development are independent of its role in pro-MMP-2 activation. Dev Biol. Jan1;277(1):255-69. [PubMed]
Oblander SA, Somerville RPT, Apte SS. (2003) An update on metalloproteases in the musculoskeletal system. Curr Opin Orthop. 14:322-328. Review.
Somerville RP, Oblander SA, Apte SS. (2003) Matrix metalloproteinases: old dogs with new tricks. Genome Biol. 4(6):216. Epub 2003 May 29. Review. [PubMed]
Complete list of Publications |
