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Research:
The general interest of the lab is to decipher the molecular basis for HIV proviral latent transcription in T lymphocyte cells. My project is geared at examining the regulation of HIV transcriptional elongation in these cells. More specifically, I’m interested in investigating the molecular mechanisms by which the general transcription elongation factor P-TEFb becomes mobilized from its inactive state by stimuli that reactivate HIV transcription.
Select Publications:
Mbonye UR, Yuan C, Harris CE, Sidhu RS, Song I, Arakawa T, Smith WL. Two distinct pathways for cyclooxygenase-2 protein degradation. J Biol Chem. 2008 Mar 28;283(13):8611-23. Epub 2008 Jan 18. [PubMed]
Kang YJ, Mbonye UR, DeLong CJ, Wada M, Smith WL. Regulation of intracellular cyclooxygenase levels by gene transcription and protein degradation. Prog Lipid Res. 2007 Mar;46(2):108-25. Epub 2007 Jan 18. [PubMed]
Mbonye UR, Wada M, Rieke CJ, Tang HY, Dewitt DL, Smith WL: The 19-amino acid cassette of cyclooxygenase-2 mediates entry of the protein into the endoplasmic reticulum-associated degradation system. J Biol Chem. 2006 Nov 24;281(47):35770-8. Epub 2006 Sep 25. [PubMed]
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