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Research:
I am currently testing the hypothesis that the exosome complex is in fact a group of functionally distinct sub-complexes. To evaluate this hypothesis, I have developed an RNAi system using dsRNAs to deplete individual exosome components, and I am currently using this RNAi system to ascertain the effects of exosome subunit depletion on both exosome structure and function.
Publications:
Graham, A.C., Kiss, D.L., and Andrulis E.D.. (2006) Differential Distribution of Exosome Subunits at the Nuclear Lamina and in Cytoplasmic Foci. Mol Biol Cell. Mar; 17(3):1399-409. [PubMed]
Gopalan S, Kasza A, Xu W, Kiss DL, Wilczynska KM, Rydel RE, Kordula T. Astrocyte- and hepatocyte-specific expression of genes from the distal serpin subcluster at 14q32.1 associates with tissue-specific chromatin structures. J Neurochem. 2005 Aug;94(3):763-73. [PubMed]
Kiss DL, Xu W, Gopalan S, Buzanowska K, Wilczynska KM, Rydel RE, and
T. Kordula (2005). "Duration of alpha1-antichymotrypsin gene
activation by interleukin-1 is determined by efficiency of inhibitor of
nuclear factor kappaB alpha resynthesis in primary human astrocytes." J
Neurochem. Feb;92(4):730-8. [PubMed]
Kasza, A., D. L. Kiss, S. Gopalan, W. Xu, R. E. Rydel, A. Koj and T. Kordula (2002). "Mechanism of plasminogen activator
inhibitor-1 regulation by oncostatin M and interleukin-1 in human
astrocytes." J Neurochem . 83(3): 696-703. [PubMed]
Complete list of Publications |
