Research:
Our lab has developed a model system using Jurkat T cells that are latently infected with HIV to study transcriptional mechanisms associated with latency. My focus is specifically to examine the contribution of chromatin restriction at the HIV provirus. This includes the analysis and manipulation of chromatin modifying complexes and specific nucleosomes that are precisely situated along the provirus.
Publications:
Kreisman LS, Friedman JH, Neaga A, Cobb BA. Structure and function relations with a T-cell activating polysaccharide antigen using circular dichroism. Glycobiology 2007 17(1): 46-55. [PubMed]
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