My Research focuses on cardiac transcriptional regulation in both developmental and pathological settings. I am interested in determining the cardiac transcriptional pathway of embryonic stem cells as they differentiate to cardiac myocytes. I have developed a novel fate mapping strategy in murine embryonic stem cells to identify the temporal expression profile of cardiac assoicated transcription factors as they differentiate into cardiac myocytes. I am also interested in determing the role of Notch signaling in the transcriptional regulation of cardiac myocytes adaption to pressure overload.
Mayorga M, Finan A, Penn M.
Pre-transplantation specification of stem cells to cardiac lineage for regeneration of cardiac tissue. Stem Cell Rev. 2009 Mar;5(1):51-60.
Cassano M, Biressi S, Finan A, Benedetti L, Omes C, Boratto R, Martin F, Allegretti M, Broccoli V, Cusella De Angelis G, Comoglio PM, Basilico C, Torrente Y, Michieli P, Cossu G, Sampaolesi M.
Magic-factor 1, a partial agonist of Met, induces muscle hypertrophy by protecting myogenic precursors from apoptosis. PLoS One 3 (2008). [PubMed]
Schenk S, Mal N, Finan A, Zhang M, Kiedrowski M, Popovic Z, McCarthy PM, Penn MS. Monocyte chemotactic protein-3 is a myocardial mesenchymal stem cell homing factor.
Stem Cells. 2007 Jan;25(1):245-51 [PubMed]