Our lab studies the receptor protein tyrosine phosphatase, PTPmu. The main focus of my research is the development and characterization of PTPmu probes that can be used as diagnostic and therapeutic tools for treatment of glioblastoma multiforme and other cancers. I utilize a variety of imaging techniques, including in vivo fluorescence and magnetic resonance imaging.
Burden-Gulley*, S.M., Zhou*, Z., Ensslen-Craig, S., Lu, Z.R., Brady-Kalnay, S.M. Molecular imaging of glioma with a PTPmu targeted contrast agent. Translational Oncology, In press. *These authors contributed equally to this manuscript.
Burden-Gulley*, S.M., Qutaish*, M.Q., Sullivant, K.E., Tan, M., Craig, S.E., Basilion, J.P., Lu, Z.R., Wilson, D.L., Brady-Kalnay, S.M. Single cell molecular recognition of migrating and invading tumor cells using a targeted fluorescent probe to receptor PTPmu. International Journal of Cancer, 2012 Sep 14. doi: 10.1002/ijc.27838. [Epub ahead of print]. [PubMed] *These authors contributed equally to this manuscript
Qutaish, M.Q., Sullivant, K.E., Burden-Gulley, S.M., Lu, H., Roy, D., Wang, J., Basilion, J.P., Brady-Kalnay, S.M., Wilson, D.L. Cryo-image analysis of tumor cell migration, invasion, and dispersal in a mouse xenograft model of human glioblastoma multiforme. Molecular Imaging and Biology, 2012 Oct; 14(5):572-83. [PubMed]
Kaur, H., Burden-Gulley-S.M., Phillips-Mason, P.J., Craig, S.E., Basilion, J.P., Sloan, A.E, Brady-Kalnay, S.M. Protein Tyrosine Phosphatase mu (PTPµ) regulates glioblastoma cell growth and survival in vivo. Neuro-Oncology, 2012 May;14(5):561-73. Epub 2012 Apr 14. [PubMed]
Burden-Gulley, S.M., Qutaish, M.Q., Sullivant, K.E., Lu, H., Wang, J., Craig, S.E., Basilion, J.P., Wilson, D.L., Brady-Kalnay, S.M. Novel cryo-imaging of the glioma tumor microenvironment reveals migration and dispersal pathways in vivid three-dimensional detail. Cancer Research, 2011; 7:5932-5940. [PubMed] *An image from this article was featured on the cover of the journal.
Burden-Gulley, S.M., Gates, T.J., Cutter, J., Burgoyne, A.M., Robinson, S., Sloan, A.E., Miller, R.H., Basilion, J., Brady-Kalnay, S.M. A novel molecular diagnostic of glioblastomas: detection of an extracellular fragment of PTPµ.Neoplasia, 2010; 12(4):305-16. [PubMed]