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Research Interests:
'Research interests includes HIV/AIDS, hemorrhagic viral fevers (Marburg and Ebola). Since 2003 until joining Graduate School at Case Western Reserve University in middle of 2009, I was involved in HIV-1 Vaccine clinical trials and Research; in Uganda with the Makerere University Walter Reed Project (MUWRP) first as a Research Assistant and later as a Laboratory Scientific Officer. MUWRP is research collaboration between the Makerere University College of Health Sciences and the U.S Military HIV Research Program. While working at MUWRP, I was involved in routine follow up of vaccinated participants through immunephenotyping, intracellular cytokine staining, viral load testing Antibody titer measurements and screening for HIV infection. I later received promotion to head the Molecular Pathology and Diagnostics section of the MWRP Laboratory. Activities in this section included routine HIV-1 subtype analysis using the Multiregion Hybridization Assay (MHAacd), Viral load testing, serology and Quantitative Real-Time PCR.
My PhD dissertation research involves the “Development and Characterization of a Multivalent, Multiclade HIV-1 vaccine encoding up to 500 HIV-1 Subtypes A and D Recombinant Envelopes”. Our hypothesis is that the immune system can recognize an infinite number of antigens simultaneous or in phases. We are therefore developing a vaccine and immunize macaques with a cocktail of tens or hundreds of pseudotyped viruses encoding different Envelope recombinants.
Publication:
Eller LA, Eller MA, Ouma BJ, Kataaha P, Bagaya BS, Olemukan RL, Erima S, Kawala L, de Souza MS, Kibuuka H, Wabwire-Mangen F, Peel SA, O'Connell RJ, Robb ML, Michael NL. 2007. Large-Scale Human Immunodeficiency Virus Rapid Test Evaluation in a Low-Prevalence Ugandan Blood Bank Population. JOURNAL OF CLINICAL MICROBIOLOGY, Oct. 2007, Vol. 45, No. 10 p. 3281–3285 [PubMed] |
